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Chemical Structure| 17397-93-2 Chemical Structure| 17397-93-2

Structure of Tanshinone IIB
CAS No.: 17397-93-2

Chemical Structure| 17397-93-2

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Tanshinone IIB (TSB), a natural product isolated and purified from the roots of Salvia miltiorrhiza, can significantly inhibit the DNA laddering, cytotoxicity and apoptosis of rat cortical neurons induced by staurosporine in a concentration-dependent manner. Tanshinone IIB showed inhibitory effect on PL(pro) with IC50 value of 10.7μM and less inhibitory effect on 3CLpro with IC50 value of 24.8μM.

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Product Details of Tanshinone IIB

CAS No. :17397-93-2
Formula : C19H18O4
M.W : 310.34
SMILES Code : O=C(C1=C2C=CC3=C1CCC[C@@]3(CO)C)C(C4=C2OC=C4C)=O
MDL No. :MFCD00238691

Safety of Tanshinone IIB

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT02200978 Childhood Acute Promyelocytic ... More >>Leukemia Less << Phase 4 Recruiting September 2022 China, Guangdong ... More >> The First Affiliated Hospital of Sun Yat-Sen University Recruiting Guangzhou, Guangdong, China, 510080 Contact: Xue-Qun Luo, professor       L-xuequn@126.com    Principal Investigator: Xue-Qun Luo, professor Less <<
NCT01452477 Polycystic Ovary Syndrome Not Applicable Unknown July 2014 China, Heilongjiang ... More >> Heilongjiang University of Chinese Medicine Recruiting Harbin, Heilongjiang, China, 150040 Contact: Wenjuan Shen, doctor    +86-045182118464    shenwenjuankx@163.com    Contact: Yuehui Zhang, doctor    +86-045182118464    manbingPCOS@163.com    Principal Investigator: Wenjuan Shen, doctor          China, Jiangsu Huaian Maternal and Child Health Hospital Recruiting Huaian, Jiangsu, China, 223001 Contact: Huiying Xue, Scholar    +8613505238015    haxuehuiying@126.com    Principal Investigator: Huiying Xue, bachlor          Lianyungang Maternal and Child Health Hospital Active, not recruiting Lianyungang, Jiangsu, China, 222000 China, Jiangxi JiangXi University of Traditional Chinese Medicine Completed Nanchang, Jiangxi, China, 330000 Less <<
NCT02524964 Left Ventricular Remodeling ... More >> Acute Myocardial Infarction Less << Phase 4 Unknown July 2017 China, Guangdong ... More >> Guangdong Provincial Hospital of Chinese Medicine Recruiting Guangzhou, Guangdong, China, 510120 Contact: Minzhou Zhang, Dr.    86-20-81887233 ext 32801    minzhouzhang@yeah.net    Contact: Liheng Guo, Dr.    86-8187236 ext 32907    lihengguo1@yeah.net Less <<
NCT01637675 Pulmonary Hypertension ... More >> Pulmonary Arterial Hypertension Cardiovascular Diseases Lung Diseases Tanshinone IIA Sulfonate Less << Phase 2 Phase 3 Unknown December 2014 China, Guangdong ... More >> The First Affiliated Hospital of Guangzhou Medical University Recruiting Guangzhou, Guangdong, China, 510120 Contact: Jian Wang, MD    +8615013388183    jwang31@jhmi.edu Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.22mL

0.64mL

0.32mL

16.11mL

3.22mL

1.61mL

32.22mL

6.44mL

3.22mL

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