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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
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Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 51543-40-9 Chemical Structure| 51543-40-9

Structure of Tarenflurbil
CAS No.: 51543-40-9

Chemical Structure| 51543-40-9

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(R)-Flurbiprofen is the R-enantiomer of the racemate NSAID flurbiprofen, inhibiting the binding of [3H]9-cis-RA to RXRαLBD with IC50 of 75 μM.

Synonyms: (R)-Flurbiprofen; MPC7869; E7869, E 7869, E-7869, Flurizan, Furbiprofen, MPC-7869, MPC 7869, MPC7869, (R)-Flurbiprofen

4.5 *For Research Use Only !

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Product Details of Tarenflurbil

CAS No. :51543-40-9
Formula : C15H13FO2
M.W : 244.26
SMILES Code : C[C@H](C1=CC=C(C2=CC=CC=C2)C(F)=C1)C(O)=O
Synonyms :
(R)-Flurbiprofen; MPC7869; E7869, E 7869, E-7869, Flurizan, Furbiprofen, MPC-7869, MPC 7869, MPC7869, (R)-Flurbiprofen
MDL No. :MFCD00869714
InChI Key :SYTBZMRGLBWNTM-SNVBAGLBSA-N
Pubchem ID :92337

Safety of Tarenflurbil

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H361
Precautionary Statements:P201-P202-P264-P270-P280-P301+P310+P330-P308+P313-P405-P501
Class:6.1
UN#:2811
Packing Group:

Isoform Comparison

Biological Activity

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Mice Tg2576 transgenic mice Oral 10 mg/kg/day Once daily for 4 months (preventative treatment) or 2 weeks (therapeutic treatment) To evaluate the effect of R-flurbiprofen on cognitive function and Aβ load in Tg2576 mice. Preventative treatment improved spatial learning but did not significantly reduce Aβ load; therapeutic treatment significantly reduced Aβ plaque burden but did not improve spatial learning. PMC1948891

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT02438072 Depression Not Applicable Unknown December 2015 Switzerland ... More >> Hôpitaux Universitaires de Genève Recruiting Genève, Switzerland, 1205 Contact: celia Lloret-Linares, MD, PhD    0041 79 55 36 389    celia.LloretLinares@hcuge.ch Less <<
NCT01061112 - Unknown June 2014 United States, Minnesota ... More >> Clinical and Translational Science Institute Minneapolis, Minnesota, United States, 55414 Less <<
NCT00425451 Periodontitis Phase 2 Completed - Israel ... More >> Hadassah Medical Organization Jerusalem, Israel, 91120 Less <<
NCT02206854 Healthy Volunteers Phase 1 Completed - Germany ... More >> Johann Wolfgang Goethe University Hospital Frankfurt, Germany, 60528 Less <<
NCT01040286 Periodontitis Phase 2 Completed - Israel ... More >> Department of Periodontology, School of Graduate Dentistry, Rambam Health Care Center Haifa, Israel, 9602 Less <<
NCT00045123 Prostate Cancer Phase 2 Unknown - -

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.09mL

0.82mL

0.41mL

20.47mL

4.09mL

2.05mL

40.94mL

8.19mL

4.09mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

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