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Chemical Structure| 1453099-83-6 Chemical Structure| 1453099-83-6

Structure of TAS-119
CAS No.: 1453099-83-6

Chemical Structure| 1453099-83-6

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TAS-119 is a highly potent, selective, and orally active Aurora A inhibitor with an IC50 of 1.0 nM. It exhibits significantly higher selectivity for Aurora A over other protein kinases, including Aurora B (IC50 = 95 nM), and demonstrates notable antitumor activity.

Synonyms: TAS-119

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Product Details of TAS-119

CAS No. :1453099-83-6
Formula : C23H22Cl2FN5O3
M.W : 506.36
SMILES Code : O=C(C1(CC2=NC(NC3=NNC(C)=C3)=C(F)C=C2)CCN(C(C4=CC=CC(Cl)=C4Cl)=O)CC1)O
Synonyms :
TAS-119

Safety of TAS-119

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of TAS-119

epigenetics
DNA

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT02448589 Advanced Solid Tumors PHASE1 TERMINATED 2025-08-19 University Hospitals - Seidman... More >> Cancer Center, Cleveland, Ohio, 44106, United States|San Raffaele Hospital, Milano, 20132, Italy|Erasmus MC Cancer Institute, Rotterdam, 3015CE, Netherlands|START MADRID-FJD, Hospital Fundación Jiménez Díaz, Madrid, 28040, Spain|START Madrid Unidad de Ensayos Fase I, Madrid, 28050, Spain|The Institute of Cancer Research, Sutton, Surrey, SM2 5NG, United Kingdom Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.97mL

0.39mL

0.20mL

9.87mL

1.97mL

0.99mL

19.75mL

3.95mL

1.97mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2
 

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