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Chemical Structure| 1848959-11-4 Chemical Structure| 1848959-11-4

Structure of TAS4464 HCl
CAS No.: 1848959-11-4

Chemical Structure| 1848959-11-4

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TAS4464 HCl is a potent and selective NEDD8 activating enzyme (NAE) inhibitor with an IC50 value of 0.955 nM.

Synonyms: TAS4464 hydrochloride

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Product Details of TAS4464 HCl

CAS No. :1848959-11-4
Formula : C21H24ClFN6O6S
M.W : 542.97
SMILES Code : O[C@@H]1[C@H](O)[C@@H](CNS(=O)(N)=O)O[C@]1(N2C=C(C#CC3=C(OCC)C=CC=C3F)C4=C(N)N=CN=C24)[H].Cl
Synonyms :
TAS4464 hydrochloride
MDL No. :MFCD32067968
InChI Key :CDCFJYCKNAWPTL-WVAMHNCPSA-N
Pubchem ID :124121823

Safety of TAS4464 HCl

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Isoform Comparison

Biological Activity

Description
TAS4464 (hydrochloride) is a highly potent and selective inhibitor of the NEDD8 activating enzyme (NAE), demonstrating an IC50 value of 0.955 nM[1].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.84mL

0.37mL

0.18mL

9.21mL

1.84mL

0.92mL

18.42mL

3.68mL

1.84mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

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