Name: Taurodeoxycholic acid sodium hydrate | Sodium taurodeoxycholate monohydrate; Taurodeoxycholic acid(sodium hydrate)
Brand: Ambeed
SKU: A173783
Rating: 4.4 (200 reviews)

CAS No. :	110026-03-4
Formula :	C₂₆H₄₆NNaO₇S
M.W :	539.70
SMILES Code :	C[C@]12[C@@H](O)C[C@@]3([C@@]4(C)CC[C@@H](O)C[C@]4(CC[C@]3([C@@]1(CC[C@@]2([C@@H](CCC(NCCS([O-])(=O)=O)=O)C)[H])[H])[H])[H])[H].[H]O[H].[Na+]
Synonyms :	Sodium taurodeoxycholate monohydrate; Taurodeoxycholic acid(sodium hydrate)
MDL No. :	MFCD00149238

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P280-P301+P312-P302+P352-P305+P351+P338

MC3T3-E1 cells	3 µg/l	14 or 21 days	To assess osteogenic potential, results showed that Se/TUDCA significantly increased ALP expression and calcified nodule formation	J Mater Sci Mater Med. 2024 Oct 15;35(1):64
RAW264.7 macrophages	100 µM	24 hours	To evaluate the effect of TUDCA on the intracellular survival of B. pseudomallei in RAW264.7 macrophages, results showed that TUDCA significantly reduced the intracellular survival of B. pseudomallei.	BMC Microbiol. 2021 May 4;21(1):137
C2C12 murine myotubes	50 µM	48 hours	TDCA increased myotube diameter and prevented dexamethasone-induced atrophy	Gut Microbes. 2025 Dec;17(1):2449586
MC3T3-E1 cells	3 µg/l	72 hours	To evaluate cell proliferation and differentiation, results showed that Se/TUDCA significantly promoted MC3T3-E1 cell proliferation and osteogenic potential	J Mater Sci Mater Med. 2024 Oct 15;35(1):64
CD4+ T cells	100 µM TDCA and 100 mM valine	72 hours	To evaluate the effect of TDCA and valine on the interaction between CD4+ T cells and M1 macrophages. Results showed that TDCA and valine significantly reduced the frequencies of CD4+IFN-γ+ and CD4+IL-17A+ T cells.	Am J Transplant. 2022 Feb;22(2):402-413
Splenic monocytes	100 µM TDCA and 100 mM valine	96 hours	To evaluate the effect of TDCA and valine on LPS-induced M1 macrophage polarization. Results showed that TDCA and valine significantly reduced LPS-induced polarization of F4/80+CD11b+CD11c+ M1 macrophages.	Am J Transplant. 2022 Feb;22(2):402-413

Mice	C26 cancer cachexia model	Intraperitoneal injection	10 mg/kg	Daily administration until the end of the experiment	TDCA improved cholesterol homeostasis and reduced hepatic cholesterol levels but did not prevent muscle atrophy	Gut Microbes. 2025 Dec;17(1):2449586
Pigs	PRRSV inactivated vaccine immunization model	Oral	10 mg/kg	7 days	RPP treatment significantly increased the concentrations of PRRSV GP5 protein antibody, IL-2, IL-4, IL-10, and IFN-γ, and optimized gut flora and blood metabolites.	Front Immunol. 2024 Jun 26;15:1352018
C57BL/6 mice	Melioidosis model	Injection	100 μg/g	Every 2 days for 10 days	To assess the effect of TUDCA on the survival of melioidosis mice, results showed that TUDCA significantly improved the survival rate of mice, reduced bacterial loads and inflammatory responses in the lungs, spleen, and liver.	BMC Microbiol. 2021 May 4;21(1):137
C57BL/6J mice	High-fat diet-induced non-alcoholic fatty liver disease (NAFLD) model	Oral	1000 mg/kg	Once daily for 4 weeks	To evaluate the therapeutic effects of TUDCA on a high-fat diet-induced NAFLD mouse model. TUDCA significantly attenuated hepatic steatosis, inflammatory responses, obesity, and insulin resistance, improved intestinal barrier function, reduced intestinal fat transport, and modulated gut microbiota composition.	Br J Pharmacol. 2018 Feb;175(3):469-484
Rd10 mice, P23H rats, BN rats, etc.	Models of RP, DR, RDT, etc.	Intraperitoneally, subcutaneously, in eye drops	100-750 mg/kg	1 day to 60 days	Protection of retinal function and structure by inhibiting apoptosis, decreasing inflammation, attenuating oxidative stress, etc.	Curr Neuropharmacol. 2024;22(8):1374-1390
Mice	Laparotomy model	Intraperitoneal injection	200 mg/kg	Single dose, 30 min before surgery	Inhibiting ER stress alleviates NLRP3 inflammasome activation and neuroinflammation, improving postoperative cognitive function	CNS Neurosci Ther. 2024 Oct;30(10):e70049
Sprague Dawley (SD) rats	Spinal cord injury (SCI) model	Oral	200 mg/kg	Once daily for 28 days	To evaluate the effects of combined TUDCA and BMSC transplantation on functional recovery and tissue regeneration in SCI rats. Results showed that TUDCA significantly accelerated tissue regeneration (assessed by HE, Nissl, MAP2, MBP, TUJ1, and GFAP) and improved functional recovery (assessed by BBB score). These effects were mediated via upregulation of Nrf-2, NQO-1, and HO-1 expression levels.	Mol Neurobiol. 2024 Jul;61(7):3753-3768
Wistar albino male rats	STZ-induced type 2 diabetes model	Intraperitoneal injection	300 mg/kg	Once daily for 15 days	To evaluate the antidiabetic effects of TUDCA in STZ-induced diabetic rats, results showed TUDCA significantly reduced blood glucose, HbA1c%, and HOMA-IR, increased insulin levels, and improved lipid metabolism, oxidative stress, inflammation, and apoptosis.	Int J Mol Sci. 2024 Jun 25;25(13):6922
C57BL/6J male mice	18-month-old aged mice model	Intraperitoneal injection	300 mg/kg	Once daily for 20 consecutive days	To evaluate the effects of TUDCA on glucose-insulin homeostasis in aged mice. Results showed TUDCA improved hyperinsulinemia and glucose homeostasis by enhancing liver insulin-degrading enzyme (IDE) expression and insulin clearance.	Sci Rep. 2022 Dec 23;12(1):22273
Sprague Dawley rats	Ovariectomized osteoporosis model	Local administration	300 μg/30 μL	Single dose, maintained for 3 months	To evaluate the effect of Se/TUDCA on bone regeneration in osteoporotic rats, results showed that Se/TUDCA significantly promoted bone regeneration and reduced oxidative stress	J Mater Sci Mater Med. 2024 Oct 15;35(1):64
C57BL/6j mice	Ocular alkali burn model	Intraperitoneal injection	400 mg/kg	Once daily for 3 days	To investigate the effect of TUDCA on inflammation after ocular alkali burn, results showed that TUDCA inhibited inflammation in the cornea and retina and protected retinal ganglion cells.	Int J Mol Sci. 2022 Oct 3;23(19):11717
Rats	ET B receptor-deficient rats	Intraperitoneal injection	400 mg/kg/day	Daily for 3 weeks	To evaluate the protective effects of TUDCA against high salt diet-induced renal injury. Results showed that TUDCA significantly reduced proteinuria and albuminuria, ameliorated glomerular and proximal tubular damage, and decreased renal cortical cell death and inflammation.	Acta Physiol (Oxf). 2019 May;226(1):e13227
C57BL/6 mice	Diet-induced obese (DIO) mouse model	Intraperitoneal injection	TDCA (50 mg/kg) and valine (200 mg/kg)	Daily injections until the end of the observation period post-transplantation	To evaluate the effect of TDCA and valine on transplant survival in obese mice. Results showed that the combined treatment of TDCA and valine significantly prolonged graft survival in obese mice, reduced the frequencies of CD4+IFN-γ+ and CD8+IFN-γ+ T cells, and increased the frequencies of Tregs and IL-10-producing CD4+ T cells.	Am J Transplant. 2022 Feb;22(2):402-413

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 110026-03-4

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CAS No.: 110026-03-4

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