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Chemical Structure| 852918-02-6 Chemical Structure| 852918-02-6

Structure of TCN 201
CAS No.: 852918-02-6

Chemical Structure| 852918-02-6

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TCN-201 is a sulphonamide derivative that negatively modulates glycine binding to the GluN1 (glutamate receptor subunit) subunit of the receptor.

Synonyms: TCN 201

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Product Details of TCN 201

CAS No. :852918-02-6
Formula : C21H17ClFN3O4S
M.W : 461.89
SMILES Code : ClC1=C(F)C=CC(S(=O)(NCC2=CC=C(C(NNC(C3=CC=CC=C3)=O)=O)C=C2)=O)=C1
Synonyms :
TCN 201
MDL No. :MFCD06683895
InChI Key :FYIBXBFDXNPBSF-UHFFFAOYSA-N
Pubchem ID :4787937

Safety of TCN 201

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H335
Precautionary Statements:P261

Isoform Comparison

Biological Activity

Description
TCN 201 is a potent, selective, and non-competitive antagonist of the GluN1/GluN2A NMDA receptor, exhibiting a pIC50 value of 6.8. It shows selectivity for the GluN1/GluN2A NMDA receptor over the GluN1/GluN2B NMDA receptor (pIC50<4.3) [1][2].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.17mL

0.43mL

0.22mL

10.83mL

2.17mL

1.08mL

21.65mL

4.33mL

2.17mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

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