Name: Teneligliptin HBr | MP-513 hydrobromide; Teneligliptin hydrobromide anhydrous
Brand: Ambeed
SKU: A253925
Rating: 4.3 (180 reviews)

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CAS No. :	906093-29-6
Formula :	C₄₄H₆₅Br₅N₁₂O₂S₂
M.W :	1257.72
SMILES Code :	O=C(N1CSCC1)[C@H]2NC[C@H](C2)N3CCN(CC3)C4=CC(C)=NN4C5=CC=CC=C5.[H]Br.[H]Br.[H]Br.[H]Br.[H]Br.O=C(N6CSCC6)[C@H]7NC[C@H](C7)N8CCN(CC8)C9=CC(C)=NN9C%10=CC=CC=C%10
Synonyms :	MP-513 hydrobromide; Teneligliptin hydrobromide anhydrous; Teneligliptin hydrobromide
MDL No. :	MFCD23098790

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

3T3-L1 adipocytes	1, 5, 10 µM	12 hours	With DPP-4 pretreatment for 12 hours, teneligliptin significantly decreased the expression of Xdh by 19%, 30%, and 26% (at 1, 5, and 10 μM concentrations, respectively).	J Diabetes Res. 2016;2016:3201534
Primary human brain microvascular endothelial cells (HBMVECs)	1, 3 mM	24 and 48 hours	Teneligliptin significantly attenuated OGD/R-induced reduction in cell viability and decreased LDH release, indicating its protective effect against ischemia/reperfusion-induced cell death.	RSC Adv. 2020 Jan 22;10(7):3765-3774
Primary mouse cardiomyocytes	2.5 or 5 µM	24 hours	Teneligliptin significantly inhibited high glucose-induced NLRP3 inflammasome activation and increases in myocardial injury indicators (CK-MB, AST), and increased p-AMPK levels.	World J Diabetes. 2024 Apr 15;15(4):724-734
3T3-L1 adipocytes	1, 5, 10 µM	3 hours	Teneligliptin significantly decreased the expression of Xdh by 45%, 35%, and 34% (at 1, 5, and 10 μM concentrations, respectively).	J Diabetes Res. 2016;2016:3201534
Human umbilical vein endothelial cells (HUVECs)	5 µM	48 hours	TE alone or combined with CA promoted increased E-cadherin expression and suppressed VEGF expression.	Int J Mol Sci. 2020 Mar 21;21(6):2164
Activated hepatic stellate cells (Ac-HSCs)	5 µM	48 hours	TE alone or combined with CA significantly attenuated Ac-HSC proliferation as well as TGF-β1 and α1(I)-procollagen mRNA expression.	Int J Mol Sci. 2020 Mar 21;21(6):2164

Fischer 344 rats	Choline-deficient, L-amino acid-defined diet (CDAA)-induced non-alcoholic steatohepatitis (NASH) model	Oral gavage	0.3 mg/kg/day	Once daily for 16 weeks	TE significantly attenuated CDAA diet-induced hepatic fibrogenesis and carcinogenesis by inhibiting HSC activation, angiogenesis, and oxidative stress.	Int J Mol Sci. 2020 Mar 21;21(6):2164
Wistar rats	Streptozotocin-induced diabetic neuropathic pain model	Intrathecal injection	2 µg/h	Continuous for 7 days at a rate of 1 µL/h	Co-infusion of Teneligliptin with morphine significantly attenuated morphine analgesic tolerance in diabetic neuropathic pain rats by restoring the expression of neuroprotective proteins Nrf2 and HO-1 and suppressing microglial cell activation in the spinal dorsal horn.	Antioxidants (Basel). 2023 Jul 24;12(7):1478
Japanese patients with type 2 diabetes	Human patients	Oral	20 mg	Once daily for 4 days	Add-on treatment with teneligliptin significantly improved 24-h mean glucose levels, the proportion of time in normoglycemia, mean amplitude of glycemic excursions, and total area under the curve within 2 h after each meal. The proportion of time in hypoglycemia and hsCRP levels did not increase significantly compared with before teneligliptin. Values of 1,5-AG and GA were significantly improved by treatment with teneligliptin.	Diabetes Technol Ther. 2014 Dec;16(12):840-5
C57BL/6 male mice	Streptozotocin (STZ)-induced diabetic mouse model	Oral	30 mg/kg	Once daily for 4 weeks	Teneligliptin significantly reversed the deterioration of myocardial hypertrophy, cardiac function indicators (fractional shortening, ejection fraction, heart rate), reduced myocardial injury indicators (CK-MB, AST, LDH) levels, and inhibited NLRP3 inflammasome activation and IL-1β release in diabetic mice.	World J Diabetes. 2024 Apr 15;15(4):724-734
ICR mice	MSG/HFD-induced NAFLD model mice	Oral administration in drinking water	30 mg/kg per day	Daily administration for 10 weeks	Teneligliptin improved the histopathological appearance of the liver and decreased intrahepatic triglyceride levels, associated with downregulation of hepatic lipogenesis-related genes due to AMPK activation.	Int J Mol Sci. 2015 Dec 8;16(12):29207-18
C57/BL6 mice	MCAO mouse model	Intraperitoneal injection	30 mg/kg/day	Once daily for 14 days	Teneligliptin significantly reduced brain infarct volume, ameliorated neurological damage, and improved brain permeability by increasing the expression of the tight junction protein occludin.	RSC Adv. 2020 Jan 22;10(7):3765-3774
Male Wistar rats	High-fat diet (HFD)-induced obesity model	Oral	4.0 mg/kg/day	Once daily for 4 weeks	Under the HFD condition, teneligliptin significantly decreased plasma uric acid levels (by 21%) and significantly reduced Xdh expression in epididymal adipose tissue (by 32%).	J Diabetes Res. 2016;2016:3201534
Wistar rats	Partial sciatic nerve transection (PSNT)-induced neuropathic pain model	Intrathecal injection	5 µg/1 µL/h	Continuous for 7 days	Teneligliptin had mild antinociceptive effects against acute pain but remarkable analgesic effects against neuropathic pain. Additionally, Teneligliptin alleviated pain by suppressing spinal astrocyte activation.	Antioxidants (Basel). 2021 Sep 9;10(9):1438
Human	Patients with type 2 diabetes mellitus	Oral	5 mg, 10 mg, 20 mg, 40 mg	Once daily for 12 to 24 weeks	To evaluate the efficacy and safety of teneligliptin in patients with type 2 diabetes mellitus. Results showed that compared to placebo, teneligliptin at doses of 5 mg, 10 mg, 20 mg, and 40 mg demonstrated better efficacy in reducing HbA1c and fasting plasma glucose (FPG), with acceptable safety.	Front Endocrinol (Lausanne). 2023 Dec 18;14:1282584
Mice	Db/db diabetic mice	Oral	60 mg/kg/day	Once daily for 10 weeks	Teneligliptin alleviated diabetes-related cognitive impairment by inhibiting the ER stress and NLRP3 inflammasome	Aging (Albany NY). 2023 Dec 19;16(9):8336-8347

Bio Calculators
Preparing Stock Solutions		1mg	5mg	10mg
Preparing Stock Solutions	1 mM 5 mM 10 mM	0.80mL 0.16mL 0.08mL	3.98mL 0.80mL 0.40mL	7.95mL 1.59mL 0.80mL
Dissolving Methods	Animal experiment Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn: in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Protocol 1 Protocol 2 The prepared working fluid is recommended to be prepared now and used up as soon as possible in a short period of time. The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Protocol 1

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 906093-29-6

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CAS No.: 906093-29-6

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