Structure of Terephthalic acid
CAS No.: 100-21-0
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Terephthalic acid, a raw material for polyethylene terephthalate (PET) production, is one of the most important chemicals in petrochemical industry.
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Batch number can be found on the product's label following the word 'Batch'.
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Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Rasheed, Sufian ; Ikram, Muhammad ; Fatima, Batool ; Alomayri, Thamer ; Hussain, Dilshad ;
Abstract: Selective and sensitive detection of sarcosine biomarkers is highly important in early-stage prostate cancer diagnosis. Sarcosine is a promising biomarker present in urine and plasma samples that can be monitored effectively by biosensors. The work presents a novel metal-organic framework (MOF)-derived GC@NiVO4 composite for non-enzymatic sarcosine detection, a promising prostate cancer biomarker. This newly designed composite was synthesized through a multi-step process involving the preparation of a Ni-BDC MOF, followed by vanadium doping (V@NiBDC-MOF) and calcination to obtain the MOF-derived graphitic carbon-decorated NiVO4 composite (GC@NiVO4). Characterization results confirmed the porous graphitic carbon, with NiVO4 embedded within the graphitic carbon matrix. This unique composition offers an exceptional surface for effective analyte adsorption in electrochemical sensing applications. Cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and chronoamperometry were employed to quantify the sarcosine in order to evaluate the detection capabilities. The GC@NiVO4-based sensor exhibited an impressive limit of detection (LOD) of 0.03 µM and a limit of quantification (LOQ) of 0.1 µM, surpassing the sensitivity of enzymatic-based detection sensors currently available for sarcosine. Practical applicability was assessed through recovery experiments in real urine samples. The developed composite demonstrated a 95–105 % recovery, highlighting its potential for clinical utilization in prostate cancer diagnosis and monitoring. Moreover, the sensor exhibited excellent stability, maintaining reliable performance for up to 100 cycles of sarcosine detection, showcasing its robustness and durability for repeated use. Additionally, reproducibility was confirmed by detecting sarcosine in three cycles, consistently yielding accurate results.
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Sol R. Martínez ; Emmanuel Odell ; Luis E. Ibarra ; Arianna Sosa Lochedino ; Ana B. Wendel ; Andrés M. Durantini , et al.
Abstract: Sonodynamic inactivation (SDI) of pathogens has an important advantage when compared to optical excitation-based protocols due to the deeper penetration of ultrasound (US) excitation in biological media or animal tissue. Sonosensitizers (SS) are compounds or systems that upon US stimulation in the therapeutic window (frequency = 0.8–3 MHz and intensity < 3 W/cm2) can induce damage to vital components of pathogenic microorganisms. Herein, we report the synthesis and application of conjugated polymer nanoparticles (CPNs) as an efficient SS in SDI of methicillin-resistant Staphylococcus aureus (MRSA), Klebsiella pneumoniae and Candida tropicalis. A frequent problem in the design and testing of new SS for SDI is the lack of proper sonoreactor characterization which leads to reproducibility concerns. To address this issue, we performed dosimetry experiments in our setup. This enables the validation of our results by other researchers and facilitates meaningful comparisons with different SDI systems in future studies. On a different note, it is generally accepted that the mechanisms of action underlying SS-mediated SDI involve the production of reactive oxygen species (ROS). In an attempt to establish the nature of the cytotoxic species involved in our CPNs-based SDI protocol, we demonstrated that singlet oxygen (1O2) does not play a major role in the observed sonoinduced killing effect. SDI experiments in planktonic cultures of optimally growing pathogens using CPNs result in a germicide effect on the studied pathogenic microorganisms. The implementation of SDI protocols using CPNs was further tested in mature biofilms of a MRSA resulting in ∼40 % reduction of biomass and ∼70 % reduction of cellular viability. Overall, these results highlight the unique and unexplored capacity of CPNs to act as sonosensitizers opening new possibilities in the design and application of novel inactivation protocols against morbific microbes.
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Keywords: Sonodynamic inactivation ; Conjugated polymer nanoparticles ; Microbes ; Biofilm ; Drug-resistant microorganism
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CAS No. : | 100-21-0 |
Formula : | C8H6O4 |
M.W : | 166.13 |
SMILES Code : | O=C(O)C1=CC=C(C(O)=O)C=C1 |
MDL No. : | MFCD00002558 |
InChI Key : | KKEYFWRCBNTPAC-UHFFFAOYSA-N |
Pubchem ID : | 7489 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H335 |
Precautionary Statements: | P261-P301+P312-P302+P352-P304+P340-P305+P351+P338 |
Tags: Terephthalic acid | Carboxylic Acids | Skin Tumor Model | Others | Structure | Tumor Models | Steroids | Biological Buffers | Fluorescence Labeling Reagents | Organic Building Blocks | Fluorescent Dyes | Small Molecule Positive Drugs | Other Inhibitors/Agonists | 100-21-0
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Code | Phrase |
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P305 | IF IN EYES: |
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P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
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P378 | |
P380 | Evacuate area. |
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P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
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P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
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Storage | |
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P420 | Store away from other materials. |
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P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
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H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
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H220 | Extremely flammable gas |
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H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
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H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
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Health hazards | |
Code | Phrase |
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H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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