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Chemical Structure| 56-34-8 Chemical Structure| 56-34-8

Structure of Tetraethylammonium chloride
CAS No.: 56-34-8

Chemical Structure| 56-34-8

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Tetraethylammonium chloride is a non-selective potassium channel blocker. Tetraethylammonium chloride is a good substrate for organic cation transporter (OCTN1). Tetraethylammonium chloride antitumor properties.

Synonyms: TEA chloride

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Product Details of Tetraethylammonium chloride

CAS No. :56-34-8
Formula : C8H20ClN
M.W : 165.70
SMILES Code : CC[N+](CC)(CC)CC.[Cl-]
Synonyms :
TEA chloride
MDL No. :MFCD00011828
InChI Key :YMBCJWGVCUEGHA-UHFFFAOYSA-M
Pubchem ID :5946

Safety of Tetraethylammonium chloride

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

Description
Tetraethylammonium chloride is recognized as a non-selective blocker of potassium channels and is also an effective substrate for the organic cation transporter (OCTN1). It exhibits notable antitumor properties[1].[2].

In Vitro:

Cell Line
Concentration Treated Time Description References
Rat brain synaptic membranes 6 mM 100 minutes Tetraethylammonium chloride (TEA) at 6 mM concentration inhibited the binding of 125I-apamin to the solubilized receptor, indicating its role as a potassium channel blocker. J Neurosci. 1987 Feb;7(2):565-70
BY-2 cells 10 mM 12 hours To study the inhibitory effect of TEA+ on potassium channels in BY-2 cells, results showed that TEA+ significantly inhibited K+ influx J Nanobiotechnology. 2020 Jan 28;18(1):21
Human colon circular muscle strips 10 mM 30 minutes To study the effect of TRPM8 activation on human colon smooth muscle contractions, results showed TEA significantly reduced the inhibitory effect of DIPA 1-8 Int J Mol Sci. 2020 Jul 29;21(15):5403
HeLa cells 20 mM 36 hours To investigate the inhibitory effect of TEA on HeLa cell proliferation and its ability to induce apoptosis. Results showed that TEA reduced HeLa cell viability dose-dependently and significantly increased the apoptosis rate. J Biol Chem. 2014 Jan 24;289(4):2217-29

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

6.04mL

1.21mL

0.60mL

30.18mL

6.04mL

3.02mL

60.35mL

12.07mL

6.04mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2
The prepared working fluid is recommended to be prepared now and used up as soon as possible in a short period of time. The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1

References

 

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