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Chemical Structure| 64603-91-4 Chemical Structure| 64603-91-4

Structure of THIP
CAS No.: 64603-91-4

Chemical Structure| 64603-91-4

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THIP (Gaboxadol) is a selective extra-synaptic GABAA receptor (eGABARs) agonist that can cross the blood-brain barrier, with an EC50 value of 13 µM for δ-GABAAR. THIP induces a strong tonic GABAA-mediated current in layer 2/3 neurons but does not affect miniature IPSCs, making it suitable for sleep disorder research.

Synonyms: Gaboxadol

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Product Details of THIP

CAS No. :64603-91-4
Formula : C6H8N2O2
M.W : 140.14
SMILES Code : O=C1NOC2=C1CCNC2
Synonyms :
Gaboxadol
MDL No. :MFCD05664626

Safety of THIP

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT00209846 Primary Insomnia PHASE3 COMPLETED 2025-11-06 Non-US study, principal locati... More >>on:, G?teborg, Sweden Less <<
NCT00209924 Primary Insomnia PHASE3 COMPLETED 2025-11-05 Non-US study, principal locati... More >>on:, G?teborg, Sweden Less <<
NCT00209963 Primary Insomnia PHASE3 COMPLETED 2025-03-05 -
NCT00209950 Primary Insomnia PHASE3 COMPLETED 2025-09-05 Non-US study, principal locati... More >>on:, Regensburg, Germany Less <<
NCT00209937 Primary Insomnia PHASE3 COMPLETED 2025-06-04 -

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

7.14mL

1.43mL

0.71mL

35.68mL

7.14mL

3.57mL

71.36mL

14.27mL

7.14mL

 

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