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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 14325-05-4 Chemical Structure| 14325-05-4

Structure of 14325-05-4

Chemical Structure| 14325-05-4

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Tin protoporphyrin IX dichloride is a potent heme oxygenase-1 (HO-1) inhibitor that enhances the sensitivity of pancreatic ductal adenocarcinoma (PDAC) cells to chemotherapy drugs by inhibiting HO-1 expression.

Synonyms: Tin-protoporphyrin IX; Sn-Protoporphyrin; NSC 267099

4.5 *For Research Use Only !

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Product Details of Tin protoporphyrin IX dichloride

CAS No. :14325-05-4
Formula : C34H32Cl2N4O4Sn
M.W : 750.26
SMILES Code : CC1=C(C2=CC3=C(C(C)=C4C=C5N=C(C(C)=C5C=C)C=C6N([Sn](Cl)(N34)Cl)C(C(C)=C6C=C)=CC1=N2)CCC(O)=O)CCC(O)=O
Synonyms :
Tin-protoporphyrin IX; Sn-Protoporphyrin; NSC 267099
MDL No. :MFCD00216794

Safety of Tin protoporphyrin IX dichloride

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301+H311+H331-H315-H319
Precautionary Statements:P501-P261-P270-P271-P264-P280-P337+P313-P305+P351+P338-P361+P364-P332+P313-P301+P310+P330-P302+P352+P312-P304+P340+P311-P403+P233-P405
Class:6.1
UN#:3146
Packing Group:

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
Rat isolated aorta 0.1 mM 60 min SnPP attenuated the VIP-evoked relaxation. Br J Pharmacol. 1995 May;115(1):186-90
HeLa cells 300 µM 1 hour To evaluate the effect of SnPPIX and CoPPIX on non-enveloped virus (poliovirus). Results showed that treatment had no effect on non-enveloped virus. Sci Rep. 2018 Jun 28;8(1):9805
BHK-21 cells 300 µM 1 hour To evaluate the effect of SnPPIX and CoPPIX on virus adsorption and entry into target cells. Results showed that treatment significantly reduced virus adsorption and entry. Sci Rep. 2018 Jun 28;8(1):9805
Vero cells 100 µM 16 hours To assess the ability of SnPPIX and CoPPIX to control infection progression during cell infection. Results showed that treatment significantly inhibited ZIKV and CHIKV infection. Sci Rep. 2018 Jun 28;8(1):9805
NCI-H929 cells 10 µM 24 hours To evaluate the effect of HO-1 enzymatic inhibition on BTZ efficacy. Results showed that SnPP/BTZ treatment significantly increased the percentage of apoptotic cells (20.6 ± 2.6%), indicating that HO-1 inhibition enhances BTZ cytotoxicity. Antioxidants (Basel). 2022 Apr 12;11(4):767
U266 cells 10 µM 24 hours To evaluate the effect of HO-1 enzymatic inhibition on BTZ efficacy. Results showed that SnPP/BTZ treatment significantly increased the percentage of apoptotic cells (15.9 ± 3.5%), indicating that HO-1 inhibition enhances BTZ cytotoxicity. Antioxidants (Basel). 2022 Apr 12;11(4):767
HK-2 cells 20 µM 24 hours To evaluate the effect of SnPP on ALI-induced cytotoxicity in HK-2 cells, results showed that SnPP partially restored ALI-downregulated HO-1 expression. Front Pharmacol. 2021 Jan 21;11:624529
RAW264.7 cells 50 µM 4 hours To evaluate the effect of SnPP on the survival of S. Typhimurium in RAW264.7 cells. Results showed that SnPP treatment significantly increased bacterial survival inside cells. Antioxidants (Basel). 2022 May 24;11(6):1040

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
C57BL/6J female mice Acute S. Typhimurium infection model Intraperitoneal injection 5 mg/kg Single dose 24 hours before infection To assess the effect of SnPP on acute S. Typhimurium infection. Results showed that SnPP-treated mice had significantly higher bacterial loads in blood but reduced loads in spleen, gallbladder, and feces. Antioxidants (Basel). 2022 May 24;11(6):1040

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1.33mL

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0.13mL

6.66mL

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0.67mL

13.33mL

2.67mL

1.33mL

 

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