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Chemical Structure| 1620820-12-3 Chemical Structure| 1620820-12-3

Structure of TL4-12
CAS No.: 1620820-12-3

Chemical Structure| 1620820-12-3

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TL4-12 is a selective MAP4K2/GCK inhibitor that downregulates IKZF1 and BCL-6, inhibits MM cell proliferation (IC50=37 nM), and induces apoptosis. TL4-12 can be used to overcome immunomodulatory drug resistance in multiple myeloma (MM).

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Product Details of TL4-12

CAS No. :1620820-12-3
Formula : C25H27F3N6O2
M.W : 500.52
SMILES Code : O=C(NC1=CC(C(F)(F)F)=CC(N2CCN(C)CC2)=C1)C3=CC=C(C)C(OC4=NC=NC(NC)=C4)=C3
MDL No. :MFCD31689241

Safety of TL4-12

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of TL4-12

MAPK
Hippo

Isoform Comparison

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19.98mL

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2.00mL

 

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