Name: Tofacitinib citrate | Tasocitinib citrate; CP-690550 citrate
Brand: Ambeed
SKU: A118834

NCT01023100	Arthritis, Rheumatoid	Phase 1	Completed	-	United States, Massachusetts ... More >> Pfizer Investigational Site Woburn, Massachusetts, United States, 01801 Less <<
NCT01185184	Healthy	Phase 1	Completed	-	Singapore ... More >> Pfizer Investigational Site Singapore, Singapore, 188770 Less <<
NCT01246583	Psoriasis	Phase 2	Completed	-	United States, Alabama ... More >> Pfizer Investigational Site Mobile, Alabama, United States, 36606 United States, California Pfizer Investigational Site Los Angeles, California, United States, 90045 United States, Florida Pfizer Investigational Site Orange Park, Florida, United States, 32073 United States, Nebraska Pfizer Investigational Site Omaha, Nebraska, United States, 68144 United States, New Mexico Pfizer Investigational Site Albuquerque, New Mexico, United States, 87106 United States, South Dakota Pfizer Investigational Site Rapid City, South Dakota, United States, 57702 United States, Texas Pfizer Investigational Site Dallas, Texas, United States, 75231 Canada, Ontario Pfizer Investigational Site Waterloo, Ontario, Canada, N2J 1C4 Canada, Quebec Pfizer Investigational Site Montreal, Quebec, Canada, H2K 4L5 Pfizer Investigational Site Montreal, Quebec, Canada, H3Z 2S6 Canada Pfizer Investigational Site Quebec, Canada, G1V 4X7 Less <<
NCT01101919	Healthy	Phase 1	Completed	-	China ... More >> Pfizer Investigational Site Beijing, China, 100032 Less <<
NCT01470599	Crohn's Disease	Phase 2	Completed	-	-
NCT01470599	-		Completed	-	-
NCT01710020	End-Stage Renal Disease ... More >> Hemodialysis Less <<	Phase 1	Completed	-	United States, Florida ... More >> Pfizer Investigational Site Orlando, Florida, United States, 32806 United States, Minnesota Pfizer Investigational Site Minneapolis, Minnesota, United States, 55404 Less <<
NCT01470612	Ulcerative Colitis	Phase 3	Active, not recruiting	July 27, 2020	-
NCT01710033	Kidney Transplant	Phase 1	Completed	-	United States, Alabama ... More >> Pfizer Investigational Site Birmingham, Alabama, United States, 35249-6860 Pfizer Investigational Site Birmingham, Alabama, United States, 35249 Pfizer Investigational Site Birmingham, Alabama, United States, 35294-6862 United States, California Pfizer Investigational Site Los Angeles, California, United States, 90057 United States, Indiana Pfizer Investigational Site Indianapolis, Indiana, United States, 46202 United States, Minnesota Pfizer Investigational Site Minneapolis, Minnesota, United States, 55404 United States, Missouri Pfizer Investigational Site St Louis, Missouri, United States, 63110-1093 Pfizer Investigational Site St. Louis, Missouri, United States, 63110-1092 United States, New Jersey Pfizer Investigational Site Livingston, New Jersey, United States, 07039 United States, Wisconsin Pfizer Investigational Site Madison, Wisconsin, United States, 53792 Less <<
NCT01710020	-		Completed	-	-
NCT01710033	-		Completed	-	-
NCT01277991	Arthritis, Rheumatoid	Phase 1	Completed	-	Singapore ... More >> Pfizer Investigational Site Singapore, Singapore, 188770 Less <<
NCT01740362	Renal Impairment	Phase 1	Completed	-	United States, Florida ... More >> Pfizer Investigational Site Orlando, Florida, United States, 32806 United States, Louisiana Pfizer Investigational Site New Orleans, Louisiana, United States, 70118 Pfizer Investigational Site New Orleans, Louisiana, United States, 70119 United States, Minnesota Pfizer Investigational Site Minneapolis, Minnesota, United States, 55404 Less <<
NCT01740362	-		Completed	-	-
NCT01241591	Psoriasis	Phase 3	Completed	-	-
NCT01241591	-		Completed	-	-
NCT01504113	-		Unknown	June 2015	Taiwan ... More >> National Taiwan University Dermatology department Recruiting Taipei, Taiwan, 100 Contact: Tsen-Fang Tsai, M.D. 886-2-23562141 tftsai@yahoo.com Contact: Hsien-Yi Chiu, M.D. 886-2-23123456 ext 29252192 extra.owl@msa.hinet.net Principal Investigator: Hsien-yi Chiu, M.D. Less <<
NCT01458574	Ulcerative Colitis	Phase 3	Completed	-	-
NCT01186744	Psoriasis	Phase 3	Completed	-	-
NCT01519089	Psoriasis	Phase 3	Completed	-	Japan ... More >> JR Sapporo hospital Sapporo, Hokkaido, Japan, 060-0033 Kobe University Hospital Chuo-ku, Kobe, Hyogo, Japan, 650-0017 Kanazawa Medical University Hospital Kahoku-gun, Ishikawa, Japan, 920-0293 National Hospital Organization Sagamihara National Hospital Sagamihara, Kanagawa, Japan, 252-0392 University of Miyazaki Hospital Miyazaki-shi, Miyazaki, Japan, 889-1692 Jichi Medical University Hospital Shimotsuke, Tochigi, Japan, 324-0498 Tokyo Teishin Hospital Chiyoda-ku, Tokyo, Japan, 102-8798 Tokyo medical university Hachioji medical center Hachioji, Tokyo, Japan, 193-0998 Kanto Medical Center NTT East Corporation Shinagawa-ku, Tokyo, Japan, 141-8625 Tokyo Medical University Hospital Shinjyuku-ku, Tokyo, Japan, 160-0023 Tonami General Hospital Tonami, Toyama, Japan, 939-1395 Yamanashi Prefectural Central Hospital Kofu, Yamanashi, Japan, 400-8506 Fukuoka University Hospital Fukuoka, Japan, 814-0180 Fukushima Medical University Hospital Fukushima, Japan, 960-1295 Nissay Hospital Osaka, Japan, 550-0012 Jikei University Hospital Tokyo, Japan, 105-8471 Less <<
NCT00658359	-		Completed	-	-
NCT00658359	Kidney Transplantation	Phase 2	Completed	-	-
NCT01458574	-		Completed	-	-
NCT01276639	-		Completed	-	-
NCT01186744	-		Completed	-	-
NCT01815424	Psoriasis	Phase 3	Completed	-	China, Beijing ... More >> Dept. Of dermatology &STD, Beijing Friendship Hospital, Capital Medical University Xicheng District, Beijing, China, 100050 China, Guangdong Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University Guangzhou, Guangdong, China, 510120 China, Hubei Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, Hubei, China, 430022 Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, Hubei, China, 430030 China, Jiangsu Hospital of Skin Diseases, Chinese Academy of Medical Sciences Nanjing, Jiangsu, China, 210042 China, Liaoning Department of Dermatology, The Second Affiliated Hospital of Dalian Medical University Dalian, Liaoning, China, 116027 China, Shanghai Huashan Hospital, Fudan University/Dermatology Department Shanghai, Shanghai, China, 200040 Shanghai Changhai Hospital, Dermatology Department Shanghai, Shanghai, China, 200433 China, Shanxi Dermatology Department, The First Affiliated Hospital, The Fourth Military Medical University Xi'an, Shanxi, China, 710032 China, Sichuan Sichuan Provincial People's Hospital Chengdu, Sichuan, China, 610031 West China Hospital of Sichuan University Chengdu, Sichuan, China, 610041 China, Zhejiang The First Affiliated Hospital of College of Medicine, Zhejiang University/Dermatology and STD Dept Hangzhou, Zhejiang, China, 310003 The Second Affiliated Hospital of College of Medicine, Zhejiang University Hangzhou, Zhejiang, China, 310009 China Peking University First Hospital / The Department of Dermatology Beijing, China, 100034 Peking University People's Hospital/Dermatology Department Beijing, China, 100044 Beijing Hospital of the Ministry of Health/Department of Dermatology Beijing, China, 100730 Peking Union Medical College Hospital/Department of Dermatology Beijing, China, 100730 Tianjin Medical University General Hospital, Dermatological Department Tianjin, China, 300052 Korea, Republic of Seoul National University Hospital Seoul, Korea, Republic of, 110-744 Department of Dermatology,Severance Hospital, Yonsei University Health System Seoul, Korea, Republic of, 120-452 Samsung Medical Center Seoul, Korea, Republic of, 135-710 Taiwan National Cheng-Kung University Hospital Tainan, Taiwan, 704 National Taiwan University Hospital Taipei, Taiwan, 100 Chang Gung Medical Foundation-Linkou Branch Taoyuan, Taiwan, 333 Less <<
NCT01393626	Crohn's Disease	Phase 2	Completed	-	-
NCT01393626	-		Completed	-	-
NCT01309737	Psoriasis	Phase 3	Completed	-	-
NCT01519089	-		Completed	-	-
NCT00263328	Kidney Transplantation	Phase 2	Completed	-	United States, California ... More >> Multi Organ Transplant Center Los Angeles, California, United States, 90057 St. Vincent Medical Center Los Angeles, California, United States, 90057 Transplant Research Institute Los Angeles, California, United States, 90057 Stanford School of Medicine Palo Alto, California, United States, 94304 Balboa Institute of Transplantation San Diego, California, United States, 92123 California Institute of Renal Research San Diego, California, United States, 92123 Sharp Memorial Hospital San Diego, California, United States, 92123 California Pacific Medical Center San Francisco, California, United States, 94115 University of California, San Francisco, Kidney Transplant Unit San Francisco, California, United States, 94143 Stanford University Medical Center Stanford, California, United States, 94305 United States, Colorado University of Colorado Health Sciences Center Renal Clinical Trials Office Aurora, Colorado, United States, 80045 University of Colorado Health Sciences Center Aurora, Colorado, United States, 80045 United States, Illinois Northwestern Memorial Hospital Chicago, Illinois, United States, 60611 Northwestern University-Feinberg School of Medicine, Division of Organ Transplantation Chicago, Illinois, United States, 60611 United States, Missouri Washington University School of Medicine St. Louis, Missouri, United States, 63110 United States, New York Jack J Dreyfus Clinic New York, New York, United States, 10021 Recanati/Miller Transplantation Institute New York, New York, United States, 10029 New York Presbyterian Hospital / Weill Cornell Medical Center New York, New York, United States, 10065 United States, Oregon Legacy Good Samaritan Hospital Portland, Oregon, United States, 97210 Legacy Transplant Services Portland, Oregon, United States, 97210 Northwest Renal Clinic Portland, Oregon, United States, 97210 United States, Texas Dallas Transplant Institute Dallas, Texas, United States, 75204 Annette C & Harold C Simmons Transplant Institute Dallas, Texas, United States, 75246 Baylor University Medical Center Dallas, Texas, United States, 75246 Baylor All Saints Medical Center Fort Worth, Texas, United States, 76104 United States, Wisconsin Froedtert Memorial Lutheran Hospital Milwaukee, Wisconsin, United States, 53226 Medical College of Wisconsin Milwaukee, Wisconsin, United States, 53226 Less <<
NCT01276639	Psoriasis	Phase 3	Completed	-	-
NCT01309737	-		Completed	-	-
NCT01163253	Psoriasis	Phase 3	Terminated	-	-
NCT00263328	-		Completed	-	-
NCT00106639	Kidney Transplantation	Phase 2	Completed	-	United States, California ... More >> Pfizer Investigational Site Los Angeles, California, United States, 90057 Pfizer Investigational Site Los Angeles, California, United States, 92356 Pfizer Investigational Site Palo Alto, California, United States, 94304 Pfizer Investigational Site San Diego, California, United States, 92123 Pfizer Investigational Site San Francisco, California, United States, 94115 Pfizer Investigational Site San Francisco, California, United States, 94143-0780 Pfizer Investigational Site Stanford, California, United States, 94305 United States, Colorado Pfizer Investigational Site Denver, Colorado, United States, 80262 United States, Illinois Pfizer Investigational Site Chicago, Illinois, United States, 60611 United States, Louisiana Pfizer Investigational Site New Orleans, Louisiana, United States, 70112 United States, Missouri Pfizer Investigational Site St. Louis, Missouri, United States, 63110-1092 Pfizer Investigational Site St. Louis, Missouri, United States, 63110 United States, New Jersey Pfizer Investigational Site Livingston, New Jersey, United States, 07039 United States, New York Pfizer Investigational Site New York, New York, United States, 10021 Pfizer Investigational Site New York, New York, United States, 10029 United States, Oregon Pfizer Investigational Site Portland, Oregon, United States, 97210 United States, Texas Pfizer Investigational Site Dallas, Texas, United States, 75204 Pfizer Investigational Site Dallas, Texas, United States, 75246 United States, Virginia Pfizer Investigational Site Richmond, Virginia, United States, 23298 United States, Wisconsin Pfizer Investigational Site Milwaukee, Wisconsin, United States, 53226 Less <<
NCT01163253	-		Terminated	-	-
NCT01736696	Psoriasis Imm... More >>unomodulation Less <<	Phase 1	Completed	-	United States, Arkansas ... More >> Pfizer Investigational Site Little Rock, Arkansas, United States, 72202 Less <<
NCT00106639	-		Completed	-	-
NCT00661661	Rheumatoid Arthritis	Phase 3	Completed	-	-
NCT01484561	-		Completed	-	-
NCT01393899	Crohn's Disease	Phase 2	Completed	-	-
NCT01736696	-		Completed	-	-
NCT03440892	-		Recruiting	January 2020	Sweden ... More >> Dept of Rheumatology and Inflammation research Recruiting Gothenburg, Sweden Contact: Sofia T Silfverswärd sofia.silfversward@rheuma.gu.se Less <<
NCT00661661	-		Completed	-	-
NCT01484561	Arthritis, Rheumatoid	Phase 1	Completed	-	United States, Florida ... More >> Pfizer Investigational Site South Miami, Florida, United States, 33143 United States, New York Pfizer Investigational Site Albany, New York, United States, 12206 United States, Pennsylvania Pfizer Investigational Site Duncansville, Pennsylvania, United States, 16635 United States, Texas Pfizer Investigational Site Dallas, Texas, United States, 75231 United States, Washington Pfizer Investigational Site Tacoma, Washington, United States, 98405 Czech Republic Pfizer Investigational Site Praha 4, Czech Republic, 140 59 Germany Pfizer Investigational Site Berlin, Germany, 13125 Pfizer Investigational Site Erlangen, Germany, 91054 Pfizer Investigational Site Wuerzburg, Germany, 97080 Korea, Republic of Pfizer Investigational Site Seoul, Korea, Republic of, 120-752 Mexico Pfizer Investigational Site Merida, Yucatan, Mexico, 97000 Poland Pfizer Investigational Site Bialystok, Poland, 15-354 Pfizer Investigational Site Bydgoszcz, Poland, 85-168 Pfizer Investigational Site Warszawa, Poland, 01-192 Pfizer Investigational Site Warszawa, Poland, 02-256 Pfizer Investigational Site Wroclaw, Poland, 50-088 Russian Federation Pfizer Investigational Site Moscow, Russian Federation, 115522 Pfizer Investigational Site Petrozavodsk, Russian Federation, 185019 Pfizer Investigational Site Saint Petersburg, Russian Federation, 197341 Pfizer Investigational Site St. Petersburg, Russian Federation, 194291 Spain Pfizer Investigational Site Barakaldo, Vizcaya, Spain, 48903 Pfizer Investigational Site Bilbao, Vizcaya, Spain, 48013 Pfizer Investigational Site La Coruna, Spain, 15006 Pfizer Investigational Site Sevilla, Spain, 41009 Less <<
NCT01710046	Plaque Psoriasis	Phase 2	Completed	-	United States, California ... More >> Dermatology Research Associates Los Angeles, California, United States, 90045 United States, Florida Olympian Clinical Research Tampa, Florida, United States, 33609 United States, Texas Menter Dermatology Research Institute Dallas, Texas, United States, 75246 Center for Clinical Studies Houston, Texas, United States, 77004 Center for Clinical Studies Houston, Texas, United States, 77030 Less <<
NCT01710046	-		Completed	-	-
NCT02193815	Psoriasis Vulgaris	Phase 1	Completed	-	Germany ... More >> Bioskin GmbH Hamburg, Germany, 20095 Less <<
NCT02193815	-		Completed	-	-
NCT01741493	Rheumatoid Arthritis	Phase 1	Completed	-	United States, Florida ... More >> Site Reference ID/Investigator# 95817 Miami, Florida, United States, 33136 United States, Ohio Site Reference ID/Investigator# 95816 Cincinnati, Ohio, United States, 45255 United States, Pennsylvania Site Reference ID/Investigator# 95815 Duncansville, Pennsylvania, United States, 16635 United States, Texas Site Reference ID/Investigator# 92153 Austin, Texas, United States, 78744 United States, Utah Site Reference ID/Investigator# 97177 Orem, Utah, United States, 84058 Less <<
NCT01393899	-		Completed	-	-
NCT01745055	-		Completed	-	-
NCT01513902	Juvenile Idiopathic Arthritis	Phase 1	Completed	-	United States, Minnesota ... More >> Explorer Clinic, University of Minnesota Children's Hospital Minneapolis, Minnesota, United States, 55454 Clinical and Translational Science Institute Masonic Clinical Research Unit (Administration Only) Minneapolis, Minnesota, United States, 55455 United States, Ohio Cincinnati Children's Hospital Medical Center Cincinnati, Ohio, United States, 45229 United States, Oregon Randall Children's Hospital at Legacy Emanuel Portland, Oregon, United States, 97227 Germany PRI - Pediatric Rheumatology Research Institute GmbH Bad Bramstedt, Germany, 24576 Hamburger Zentrum fuer Kinder-und Jugendrheumatologie SchoenKlinik Hamburg Eilbek Hamburg, Germany, 22081 Asklepios Klinik Sankt Augustin Gmbh St. Augustin, Germany, 53757 Poland Wojewodzki Specjalistyczny Szpital Dzieciecy im. Sw. Ludwika w Krakowie Krakow, Poland, 31-503 Klinika Kardiologii i Reumatologii Dzieciecej Lodz, Poland, 91-738 Slovakia Narodny ustav reumatickych chorob Piestany, Slovakia, 921 12 Less <<
NCT03281304	Ulcerative Colitis	Phase 3	Recruiting	November 22, 2022	-
NCT00413699	Arthritis, Rheumatoid	Phase 3	Completed	-	-
NCT01458951	Ulcerative Colitis	Phase 3	Completed	-	-
NCT00413699	-		Completed	-	-
NCT01458951	-		Completed	-	-
NCT03016884	Herpes Zoster	Phase 4	Recruiting	May 2019	Israel ... More >> Ha'Emek Medical center, Unit of Rheumatology Recruiting Afula, Israel Contact: Amir Bieber, MD 972-52-6054854 amir.bieber@gmail.com Carmel Medical Center Recruiting Haifa, Israel Contact: Devi Zissman, MD 972-4-8250486 Tel Aviv Medical Center, Unit pf Rheumatology Recruiting Tel Aviv, Israel Contact: Ori Elkayam, MD 972-3-6973248 rheumatology@tlvmc.gov.il Less <<
NCT01745055	Rheumatoid Arthritis	Phase 1	Completed	-	United States, Florida ... More >> Pfizer Investigational Site Daytona Beach, Florida, United States, 32114 Pfizer Investigational Site Fort Lauderdale, Florida, United States, 33301 Pfizer Investigational Site Miramar, Florida, United States, 33025 United States, Texas Pfizer Investigational Site Dallas, Texas, United States, 75247 Less <<
NCT02996500	Rheumatoid Arthritis	Phase 2	Completed	-	-
NCT01465763	Ulcerative Colitis	Phase 3	Completed	-	-
NCT01465763	-		Completed	-	-
NCT03073109	-		Recruiting	February 22, 2019	Colombia ... More >> Artmedica Recruiting Medellin, Antioquia, Colombia Hospital Pablo Tobon Uribe Not yet recruiting Medellin, Antioquia, Colombia Fundacion Instituto de Reumatologia Fernando Chalem Recruiting Bogota, Cundinamarca, Colombia IDEARG Recruiting Bogota, Cundinamarca, Colombia Clinica de Occidente Recruiting Cali, Valle, Colombia Centro Integral de Reumatología del Caribe Circaribe S.A Recruiting Barranquilla, Colombia Clinicos IPS Recruiting Bogota, Colombia, 111211 Centro de Investigacion en Reumatologia y Especialidades Medicas S.A.S, CIREEM Recruiting Bogotá, Colombia SERVIMED Recruiting Bucaramanga, Colombia Fundacion Valle del Lili Recruiting Cali, Colombia REUMALAB Recruiting Medellin, Colombia Peru Clinica Delgado Not yet recruiting Miraflores, Lima, Peru Clínica San Judas Tadeo Recruiting Lima, SAN Miguel, Peru, 15086 Centro Medico CEEN Recruiting Arequipa, Peru Clinica Jockey Salud Recruiting Lima, Peru Less <<
NCT03103412	Active Mild Ulcerative Colitis... More >>, Active Moderate Ulcerative Colitis, Healthy Subjects Less <<	Phase 1	Completed	-	United States, California ... More >> Anaheim Clinical Trials, LLC Anaheim, California, United States, 92801 Less <<
NCT01143805	Healthy	Phase 1	Completed	-	Singapore ... More >> Pfizer Investigational Site Singapore, Singapore, 188770 Less <<
NCT01513902	-		Completed	-	-
NCT02984020	-		Recruiting	January 2, 2020	Korea, Republic of ... More >> Chonbuk National University Hospital, Department of Rheumatology Recruiting Chonju, Chonbuk, Korea, Republic of, 561-712 Dankook University Hospotal Recruiting Cheonan, Chung NAM, Korea, Republic of, 31116 Konkuk University Chungju Hospital Recruiting Chungju-si, Chungcheongbuk-do, Korea, Republic of, 27376 Soonchunhyang University Cheonan Hospital, Department of Rheumatology Recruiting Chunan-si, Chungcheongnam-do, Korea, Republic of, 330-721 Keimyung University Dongsan Medical Center Recruiting Jung-Gu, Daegu, Korea, Republic of, 700-712 Kongyang University Hospital / Rheumatology Recruiting Seo-gu, Daejon, Korea, Republic of, 35365 Kyung Hee University Hospital at Gangdong / Rheumatology Recruiting Seoul, Gangdong-gu, Korea, Republic of, 05278 VHS Medical Center / Rheumatologist Recruiting Seoul, Gangdong-gu, Korea, Republic of, 05367 Chosun University Hospital, Rheumatism Department Recruiting Dong Gu, Gwang JU, Korea, Republic of, 61453 Division of Rheumatology Recruiting Seongnam-si, Gyeongg-do, Korea, Republic of CHA Bundang Medical Center Recruiting Seongnam-si, Gyeonggi-do, Korea, Republic of, 13496 Pusan National University Yangsan Hospital Recruiting Yangsan-si, Gyeongsangnam-do, Korea, Republic of, 50612 Yangsan Hospital-Pusan National University Recruiting Yangsan-si, Gyeongsangnam-do, Korea, Republic of, 50612 Wonkwang University Hospital / Division of Rheumatology Recruiting Iksan, Jeonlabuk-do, Korea, Republic of, 570711 Ajou University Hospital, Department of Rheumatology Recruiting Suwon-si, Kyeongki-do, Korea, Republic of, 442-712 Korea University Ansan Hospital Recruiting Ansan, Gyeonggi-do, Korea, Republic of Inje University Busan Paik hospital Recruiting Busan, Korea, Republic of, 47392 Kosin University Gospel Hospital Recruiting Busan, Korea, Republic of, 607-702 Inje University Haeundae Paik Hospital Recruiting Busan, Korea, Republic of, 612-896 Chungbuk National University Hospital Recruiting Chungcheongbuk-do, Korea, Republic of, 28644 Daegu Catholic University Medical Center, Department of Rheumatology Recruiting Daegu, Korea, Republic of, 705-718 Eulji University Hospital, Internal Medicine, Rheumatology Recruiting Daejeon, Korea, Republic of, 302-799 Inje University IlsanPaik Hospital Recruiting Goyang-si, Gyeonggi-do, Korea, Republic of Dongguk University Ilsan Medical Center Recruiting Gyeonggi-do, Korea, Republic of Gachon University Gil Hospital Recruiting Incheon, Korea, Republic of, 405-760 Division of Rheumatology Recruiting Incheon, Korea, Republic of Jeju National University Hospital Recruiting Jeju Special Self-Goverming Province, Korea, Republic of Division of Rheumatology Recruiting Metropolitan City, Daejeon, Korea, Republic of Pusan National University Hospital Recruiting Pusan, Korea, Republic of, 602-739 Dong-A University Hospital Recruiting Pusan, Korea, Republic of Hanyang Rheuma Uhm Wan-Sik Clinic Terminated Seoul, Korea, Republic of, 04782 Division of Rheumatology, SMG-SNU Boramae Medical Center Recruiting Seoul, Korea, Republic of, 07061 Seoul National University Hospital, Department of Internal Medicine Recruiting Seoul, Korea, Republic of, 110-744 Seoul National University Hospital, Rheumatology, Internal Medicine Recruiting Seoul, Korea, Republic of, 110-744 Kyung Hee University Hospital Recruiting Seoul, Korea, Republic of, 130-872 Hanyang University Hospital, Department of Rheumatology Recruiting Seoul, Korea, Republic of, 133-792 Kyunghee University East-West Neo Medical Center, 149 Sangil-dong, Gangdong-gu Recruiting Seoul, Korea, Republic of, 134-890 Samsung Medical Center, Division of Rheumatology, Department of Medicine Recruiting Seoul, Korea, Republic of, 135-710 The Catholic University of Korea, Kangnam St. Mary's Hospital/ Rheumatology, Internal Medicine Recruiting Seoul, Korea, Republic of, 137-701 The Catholic University of Korea, Seoul St. Mary's Hospital/ Rheumatology, Internal Medicine Recruiting Seoul, Korea, Republic of, 137-701 Eulji Medical Center Active, not recruiting Seoul, Korea, Republic of, 139-711 Soonchunhyang University Hospital Seoul/Department of Rheumatology Recruiting Seoul, Korea, Republic of, 140-887 Konkuk University Medical Center Recruiting Seoul, Korea, Republic of, 143-729 Division of Rheumatology Recruiting Seoul, Korea, Republic of Ewha Womans University Mokdong Hospital Recruiting Seoul, Korea, Republic of Hallym University Kangnam Sacred Heart Hospital Active, not recruiting Seoul, Korea, Republic of Kyung Hee University Medical Center Recruiting Seoul, Korea, Republic of Less <<
NCT03643211	-		Recruiting	February 25, 2022	Japan ... More >> Pfizer Local Country Office Recruiting Tokyo, Japan Less <<
NCT02157012	Rheumatoid Arthritis	Phase 4	Recruiting	March 2019	Japan ... More >> Yukio Nakamura Recruiting Matsumoto, Nagano, Japan, 3908621 Contact: Yukio Nakamura, MD, PhD yxn14@aol.jp Less <<
NCT01375127	-		Completed	-	-
NCT03755466	Rheumatoid Arthritis	Phase 2	Recruiting	November 20, 2023	Japan ... More >> Yukio Nakamura Recruiting Matsumoto, Nagano, Japan, 3908621 Contact: Yukio Nakamura, MD, PhD +81-263-37-2659 yxn14@aol.jp Principal Investigator: Yukio Nakamura, MD, PhD Less <<
NCT03112148	Healthy	Phase 1	Completed	-	United States, Connecticut ... More >> Pfizer New Haven Clinical Research Unit New Haven, Connecticut, United States, 06511 Less <<
NCT01877668	Psoriatic Arthritis	Phase 3	Completed	-	-
NCT03663400	-		Not yet recruiting	October 2019	United States, New York ... More >> New York University School of Medicine Not yet recruiting New York, New York, United States, 10016 Contact: Gregory Pappas 212-263-3095 gregory.pappas@nyumc.org Principal Investigator: David Hudesman, MD Less <<
NCT01375127	-		Completed	-	-
NCT01831466	Psoriasis Vulgaris ... More >> Psoriasis Less <<	Phase 2	Completed	-	-
NCT01877668	-		Completed	-	-
NCT03591770	Inflammatory Bowel Diseases	Phase 4	Not yet recruiting	August 2020	United States, Massachusetts ... More >> Boston Medical Center Boston, Massachusetts, United States, 02118 Less <<
NCT01204112	Healthy	Phase 1	Completed	-	United States, Connecticut ... More >> Pfizer Investigational Site New Haven, Connecticut, United States, 06511 Less <<
NCT03703817	-		Recruiting	November 30, 2018	Korea, Republic of ... More >> Chonbuk National University Hospital Recruiting Jeonju, Jeollabuk-do, Korea, Republic of, 561-712 Wonkwang University Hospital / Division of Rheumatology Recruiting Iksan, Jeonlabuk-do, Korea, Republic of, 570711 Ajou University Hospital, Department of Rheumatology Recruiting Suwon-si, Kyeongki-do, Korea, Republic of, 443-721 Eulji University Hospital Recruiting Daejeon, Republic OF Korea, Korea, Republic of, 35233 Asan Medical Center Recruiting Songpa-gu, Seoul, Korea, Republic of, 138-736 Hallym University Sacred Heart Hospital/Rheumatology, Internal Medicine Recruiting Anyang, Korea, Republic of, 431-070 Inje University Busan Paik Hospital, Department of Internal Medicine Recruiting Busan, Korea, Republic of, 614-735 Kosin University Gospel Hospital Recruiting Busan, Korea, Republic of, 6 Keimyung University Dongsan Medical Center Recruiting Daegu, Korea, Republic of, 700-712 Daegu Catholic University Medical Center, Department of Rheumatology Recruiting Daegu, Korea, Republic of, 705-718 Gacheon Medical School Gil Medical Center, Rheumatology, Internal Medicine Recruiting Incheon, Korea, Republic of, 405-760 Pusan National University Hospital Recruiting Pusan, Korea, Republic of, 602-739 Dong-A University Hospital Recruiting Pusan, Korea, Republic of Seoul National University Hospital Recruiting Seoul, Korea, Republic of, 110-744 Yonsei University Severance Hospital Recruiting Seoul, Korea, Republic of, 120-752 Kyung Hee University Hospital Recruiting Seoul, Korea, Republic of, 130-702 Hanyang University Hospital, Department of Rheumatology Recruiting Seoul, Korea, Republic of, 133-792 Catholic University of Korea, Kangnam St. Mary's Hospital Recruiting Seoul, Korea, Republic of, 137-701 Konkuk University Hospital, Department of Rheumatology Recruiting Seoul, Korea, Republic of, 143-914 Chung-Ang University Hospital Recruiting Seoul, Korea, Republic of, 156-755 Ewha Womans University Mokdong Hospital Recruiting Seoul, Korea, Republic of, 158-056 Less <<
NCT02092467	Arthritis, Rheumatoid	Phase 4	Recruiting	March 3, 2020	-
NCT02197455	-		Completed	-	-
NCT02197455	Alopecia Areata (AA) ... More >> Alopecia Totalis (AT) Alopecia Universalis (AU) Less <<	Phase 2	Completed	-	United States, Connecticut ... More >> Yale University New Haven, Connecticut, United States Less <<
NCT01882439	Psoriatic Arthritis	Phase 3	Completed	-	-
NCT01831466	-		Completed	-	-
NCT01262118	-		Completed	-	-
NCT01184092	Rheumatoid Arthritis	Phase 1	Completed	-	Singapore ... More >> Pfizer Investigational Site Singapore, Singapore, 188770 Less <<
NCT01184001	Rheumatoid Arthritis	Phase 1	Completed	-	Singapore ... More >> Pfizer Investigational Site Singapore, Singapore, 188770 Less <<
NCT03681275	Diaphragm Injury	Phase 1	Not yet recruiting	December 1, 2021	United States, California ... More >> Stanford University Medical Center Not yet recruiting Stanford, California, United States, 94305 Contact: Study team 650-721-2086 donnam@stanford.edu Less <<
NCT01226680	Keratoconjunctivitis Sicca	Phase 2	Withdrawn	October 19, 2012	-
NCT02001181	-		Completed	-	-
NCT02001181	Dermatitis, Atopic	Phase 2	Completed	-	Canada, Ontario ... More >> SKiN Centre for Dermatology Peterborough, Ontario, Canada, K9J 1Z2 The Centre for Dermatology Richmond Hill, Ontario, Canada, L4B 1A5 K. Papp Clinical Research Waterloo, Ontario, Canada, N2J 1C4 Canada, Quebec Innovaderm Research Inc. Montreal, Quebec, Canada, H2K 4L5 Canada Centre de Recherche Dermatologique du Quebec metropolitain Quebec, Canada, G1V 4X7 Less <<
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NCT01932372	-		Active, not recruiting	January 26, 2021	-
NCT01882439	-		Completed	-	-
NCT02187055	Rhematoid Arthritis	Phase 4	Completed	-	-
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NCT01164579	Rheumatoid Arthritis	Phase 2	Completed	-	-
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NCT01976364	Arthritis, Psoriatic	Phase 3	Active, not recruiting	July 11, 2019	-
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NCT01164579	-		Completed	-	-
NCT01786668	-		Completed	-	-
NCT02147587	Rheumatoid Arthritis	Phase 2	Completed	-	-
NCT01499004	Healthy	Phase 1	Completed	-	Singapore ... More >> Pfizer Investigational Site Singapore, Singapore, 188770 Less <<
NCT01731327	Healthy	Phase 1	Completed	-	Singapore ... More >> Pfizer Investigational Site Singapore, Singapore, 188770 Less <<
NCT02147587	-		Completed	-	-
NCT03502616	Ankylosing Spondylitis	Phase 3	Recruiting	August 2, 2020	-
NCT03288324	Cutaneous Lupus ... More >> Systemic Lupus Erythematosus Less <<	Phase 1 Phase 2	Recruiting	August 2020	United States, Ohio ... More >> Cincinnati Childrens Hospital Medical Center Recruiting Cincinnati, Ohio, United States, 45229 Contact: Angela SR CRC 513-803-2118 angela.merritt@cchmc.org Less <<
NCT02187055	-		Completed	-	-
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NCT02831855	Rheumatoid Arthritis	Phase 4	Recruiting	December 17, 2018	-
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NCT02281552	-		Completed	-	-
NCT03011281	-		Recruiting	December 2021	Korea, Republic of ... More >> Hanyang University Recruiting Seoul, Korea, Republic of, 04763 Contact: Yoon-kyoung Sung, MD, PhD, MPH 82-2-2290-9250 sungyk@hanyang.ac.kr Less <<
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NCT02312882	-		Completed	-	-
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CAS No. :	540737-29-9
Formula :	C₂₂H₂₈N₆O₈
M.W :	504.49
SMILES Code :	O=C(CC#N)N1C[C@H](N(C2=C3C(NC=C3)=NC=N2)C)[C@H](C)CC1.O=C(CC(C(O)=O)(O)CC(O)=O)O
Synonyms :	Tasocitinib citrate; CP-690550 citrate; CP 690,550
MDL No. :	MFCD11616529
InChI Key :	SYIKUFDOYJFGBQ-YLAFAASESA-N
Pubchem ID :	10174505

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

human rheumatoid arthritis synovial fibroblasts (RASFs)	5 µM	2 h	Inhibition of IL-6/IL-6R-induced JAK/STAT signaling and p-Akt activation	PMC8593237
Bone marrow-derived macrophages (BMDM)	300 nM	24, 48, 96 h	To evaluate the effect of Tofacitinib on TNF-α and IL-1β levels in M.tb-infected BMDM cells. Results showed that Tofacitinib treatment did not significantly alter cytokine levels.	PMC4563140
CTL effectors from C3H/HeJ mice	50 nM	96 h	Tofacitinib blocked IL-15–triggered pSTAT5 activation	PMC4362521
NK-S1 cells	1.0 μM	72 h	Induced G1 cell cycle arrest and apoptosis	PMC5940653
PBMCs	150 nM	4 days	To analyze the effects of IL-7 on the proliferation of CD28- CTLs and changes in related subpopulations, results showed that Tofacitinib significantly inhibited the effects of IL-7 on CD4+CD28- CTLs and CD8+CD28- CTLs.	PMC9301466
CD3+ peripheral T cells	10-500 nM	3 days	Tofacitinib dose-dependently inhibited T cell proliferation	PMC8688178
CD14+ monocytes	500 nM	24 h	Tofacitinib suppressed pro-inflammatory cytokine production and induced the anti-inflammatory cytokine IL-10	PMC8688178

Mice	Tuberculosis model	Oral	30 mg/kg	Twice daily for 6 months	To evaluate the acceleration of TB treatment with Tofacitinib as an adjunctive therapy. Results showed that BALB/c mice achieved apparent sterilization of the lungs at 16 weeks, while the standard treatment group required 24 weeks. C3HeB/FeJ mice showed no improvement.	PMC4563140
C3H/HeJ mice	AA model	Subcutaneous osmotic pump	15 mg/kg	Once daily for 12 weeks	Tofacitinib prevented the development of AA and blocked the expansion of CD8+NKG2D+ T cells	PMC4362521
NOD/SCID mice	NK-S1 subcutaneous xenograft model	intraperitoneal injection	25 or 50 mg/kg	14 consecutive days	Evaluated the anti-tumorigenic potential of PRN371 in NKTL, showing significant tumor growth inhibition	PMC5940653
Mice	Pdcd1−/− mice	Intraperitoneal injection	15 mg/kg	Once daily for 3 days	Tofacitinib significantly reduced KLRG1+ ILC-2 cell numbers and IL-13 cytokine production in the lungs.	PMC5461001
Mice	DSS-induced colitis model	Oral	30 mg/kg	Twice daily, starting from day 4 until the end of the experiment	Tofacitinib significantly ameliorated DSS-induced colitis, reducing histological inflammation severity and fecal inflammatory marker lipocalin 2	PMC8688178

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CAS No.: 540737-29-9

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CAS No.: 540737-29-9

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Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed