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Chemical Structure| 15421-84-8 Chemical Structure| 15421-84-8

Structure of Trapidil
CAS No.: 15421-84-8

Chemical Structure| 15421-84-8

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Trapidil is a vasodilator and antiplatelet agent with specific antagonistic activity against platelet-derived growth factor (PDGF).

Synonyms: AR-12008; Triazolopyrimidine; Trapymine

4.5 *For Research Use Only! Not for Human Use. We Do Not Sell to Patients.

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Product Details of Trapidil

CAS No. :15421-84-8
Formula : C10H15N5
M.W : 205.26
SMILES Code : CC1=NC2=NC=NN2C(N(CC)CC)=C1
Synonyms :
AR-12008; Triazolopyrimidine; Trapymine
English Name :N,N-Diethyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
MDL No. :MFCD00193104
InChI Key :GSNOZLZNQMLSKJ-UHFFFAOYSA-N
Pubchem ID :5531

Safety of Trapidil

Related Pathways of Trapidil

RTK

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT00914420 Coronary Artery Disease ... More >> Acute Coronary Syndrome Less << Phase 4 Unknown October 2012 Italy ... More >> University Hospital Modena Recruiting Modena, Italy Contact: Giuseppe M Sangiorgi, MD       sangiorgi.giuseppe@policlinico.mo.it    Principal Investigator: Giuseppe Sangiorgi, MD Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.87mL

0.97mL

0.49mL

24.36mL

4.87mL

2.44mL

48.72mL

9.74mL

4.87mL

Dissolving Methods
The prepared working fluid is recommended to be prepared now and used up as soon as possible in a short period of time. The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1

References

[1]Kim SD, Kim HN, et al. Trapidil, a platelet-derived growth factor antagonist, inhibits osteoclastogenesis by down-regulating NFATc1 and suppresses bone loss in mice. Biochem Pharmacol. 2013 Sep 15;86(6):782-90.

[2]Maresta A, Balducelli M, et al. Trapidil (triazolopyrimidine), a platelet-derived growth factor antagonist, reduces restenosis after percutaneous transluminal coronary angioplasty. Results of the randomized, double-blind STARC study. Studio Trapidil versus Aspirin nella Restenosi Coronarica. Circulation. 1994 Dec;90(6):2710-5.

[3]Kuratsu J, Ushio Y. Antiproliferative effect of trapidil, a platelet-derived growth factor antagonist, on a glioma cell line in vitro. J Neurosurg. 1990 Sep;73(3):436-40. doi: 10.3171/jns.1990.73.3.0436. PMID: 2384782.

[4]Kim SD, Kim HN, Lee JH, Jin WJ, Hwang SJ, Kim HH, Ha H, Lee ZH. Trapidil, a platelet-derived growth factor antagonist, inhibits osteoclastogenesis by down-regulating NFATc1 and suppresses bone loss in mice. Biochem Pharmacol. 2013 Sep 15;86(6):782-90. doi: 10.1016/j.bcp.2013.07.015. Epub 2013 Aug 6. PMID: 23928189.

[5]Gesualdo L, Di Paolo S, Ranieri E, Schena FP. Trapidil inhibits human mesangial cell proliferation: effect on PDGF beta-receptor binding and expression. Kidney Int. 1994 Oct;46(4):1002-9. doi: 10.1038/ki.1994.360. PMID: 7861694.

[6]Hoshiya M, Awazu M. Trapidil inhibits platelet-derived growth factor-stimulated mitogen-activated protein kinase cascade. Hypertension. 1998 Feb;31(2):665-71. doi: 10.1161/01.hyp.31.2.665. PMID: 9461238.

 

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