Structure of Tropicamide
CAS No.: 1508-75-4
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Tropicamide is a mAchR M4 antagonist, used to dilate the pupil and help with examination of the eye.
Synonyms: Ro 1-7683
4.5
*For Research Use Only !
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Batch number can be found on the product's label following the word 'Batch'.
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| CAS No. : | 1508-75-4 |
| Formula : | C17H20N2O2 |
| M.W : | 284.35 |
| SMILES Code : | O=C(N(CC)CC1=CC=NC=C1)C(C2=CC=CC=C2)CO |
| Synonyms : |
Ro 1-7683
|
| MDL No. : | MFCD00058580 |
| InChI Key : | BGDKAVGWHJFAGW-UHFFFAOYSA-N |
| Pubchem ID : | 5593 |
| GHS Pictogram: |
|
| Signal Word: | Warning |
| Hazard Statements: | H302+H312+H332-H315-H317-H319-H335 |
| Precautionary Statements: | P261-P280-P305+P351+P338 |
| Target |
|
Clinical Trial:
| NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
| NCT02124486 | Idiopathic Intracranial Hypert... More >>ension Less << | Not Applicable | Active, not recruiting | August 2, 2022 | United Kingdom ... More >> University Hospital Birmingham (Queen Elizabeth Hospital) Birmingham, West Midlands, United Kingdom, B15 2TH Less << |
| NCT00817063 | Eczema | Phase 3 | Completed | - | - |
| NCT00227253 | - | Recruiting | December 2025 | United States, Texas ... More >> University of Texas Health Science Center at San Antonio Recruiting San Antonio, Texas, United States, 78229 Contact: Jannine D Cody, Ph.D. 210-567-9220 cody@uthscsa.edu Contact: Daniel E Hale, M.D. 210-567-5284 hale@uthscsa.edu Principal Investigator: Jannine D. Cody, Ph.D. Sub-Investigator: Peter T. Fox, M.D. Principal Investigator: Daniel E. Hale, M.D. Sub-Investigator: Brian P Perry, M.D. Less << | |
| NCT00817063 | - | Completed | - | - | |
| NCT00748059 | Autonomic Nervous System Disea... More >>ses Orthostatic Hypotension Dopamine Beta-Hydroxylase Deficiency Orthostatic Intolerance Less << | Phase 1 | Active, not recruiting | December 2018 | United States, Tennessee ... More >> Vanderbilt University Nashville, Tennessee, United States, 37232 Less << |
| NCT01265719 | - | Completed | - | - | |
| NCT01827150 | Healthy | Early Phase 1 | Unknown | April 2014 | Canada, Quebec ... More >> École d'optométrie de l'Université de Montréal Recruiting Montréal, Quebec, Canada, H3T 1P1 Contact: Liliane Le-Ngoc 5148230615 liliane.linh.lan.le-ngoc@umontreal.ca Contact: Thuy-Anh Duong 5145707018 thuy-anh.duong@umontreal.ca Less << |
| NCT03362580 | - | Recruiting | December 2018 | Belgium ... More >> CHU Brugmann Recruiting Brussels, Belgium, 1020 Contact: Laurence Postelmans, MD laurence.postelmans@chu-brugmann.be Less << | |
| NCT01265719 | - | Completed | - | - | |
| NCT02443129 | Retina, Choroid, Sclera | Not Applicable | Not yet recruiting | August 2019 | - |
| NCT01982383 | Central Serous Chorioretinopat... More >>hy Less << | Not Applicable | Terminated(lack of enrollment) | - | United States, District of Col... More >>umbia George Washington University Medical Faculty Associates Washington, District of Columbia, United States, 20037 Less << |
| NCT00459303 | - | Completed | - | - | |
| NCT02271373 | Myopia | Not Applicable | Completed | - | - |
| NCT02466607 | Retinopathy | Not Applicable | Unknown | July 2015 | United States, Texas ... More >> Wedgwood Optometry Recruiting Fort Worth, Texas, United States, 76133 Contact: Olga Kraszewska, Ph.D. 682-551-2601 olgakraszewska.phd@gmail.com Less << |
| NCT02748031 | Congenital Cataract | Not Applicable | Completed | - | China, Guangdong ... More >> Zhongshan Ophthalmic Center, Sun Yat-sen University Guangzhou, Guangdong, China, 510060 Less << |
| NCT00459303 | Cataract | Phase 4 | Completed | - | Taiwan ... More >> National Taiwan University Hospital Taipei, Taiwan Less << |
| NCT01075347 | - | Completed | - | - | |
| NCT01775007 | Measurement of the Elasticity ... More >>of the Anterior Eye Segment Less << | Early Phase 1 | Unknown | January 2014 | United States, Massachusetts ... More >> Massachusetts Eye and Ear Infirmary Recruiting Boston, Massachusetts, United States, 02114 Principal Investigator: Roberto Pineda, MD Massachusetts General Hospital Recruiting Boston, Massachusetts, United States, 02114 Contact: Natalia Perrotta 617-768-8705 nperrotta@partners.org Sub-Investigator: Sebastien Besner, PhD Sub-Investigator: Giuliano Scarcelli, PhD Principal Investigator: Seok H Yun, PhD Sub-Investigator: Mehron Puoris'haag, M.D. Less << |
| NCT01982383 | - | Terminated(lack of enrollment) | - | - | |
| NCT02304861 | Cataract | Not Applicable | Completed | - | Greece ... More >> University Hospital of Alexandroupolis Alexandroupolis, Evros, Greece, 68100 Less << |
| NCT03686436 | - | Not yet recruiting | March 1, 2020 | - | |
| NCT01809483 | Erosion; Cornea, Traumatic | Phase 3 | Completed | - | Indonesia ... More >> Depatment of Ophthalmolohy, Medical Faculty, Udayana University / Sanglah Public General Hospital Denpasar, Bali, Indonesia, 80114 Less << |
| NCT02780063 | Cataract | Not Applicable | Not yet recruiting | December 2018 | United States, New York ... More >> New York University Langone Medical Center Recruiting New York, New York, United States, 10016 Contact: Christopher Lo loc04@nyumc.org Principal Investigator: Ann Ostrovsky, MD Less << |
| NCT01075347 | Corneal Epithelial Defect ... More >> Diabetic Retinopathy Penetrating Keratoplasty Less << | Phase 1 | Completed | - | Taiwan ... More >> National Taiwan University Hospital, department of Ophthalmology Taipei, Taiwan, 10047 Less << |
| NCT02895074 | Cataract | Not Applicable | Completed | - | China, Guangdong ... More >> Zhongshan Ophthalmic Center, Sun Yat-sen University Guangzhou, Guangdong, China, 510060 Less << |
| NCT02373137 | Keratoplasty ... More >>Grafting, Corneal Transplantation, Corneal Transplantation, Cornea Keratoplasty, Lamellar Less << | Phase 4 | Active, not recruiting | December 2019 | United States, California ... More >> Byers Eye Institute, Stanford University Palo Alto, California, United States, 94303 F. I. Proctor Foundation, University of California, San Francisco San Francisco, California, United States, 94143 United States, Oregon Casey Eye Institute, Oregon Health & Science University Portland, Oregon, United States, 97239 Less << |
| NCT02554396 | Presbyopia | Phase 2 | Completed | - | United States, Massachusetts ... More >> Andover Eye Associates Andover, Massachusetts, United States, 01810 Less << |
| NCT02101359 | Cataract | Phase 3 | Completed | - | France ... More >> Laboratoires Thea Clermont- Ferrand, France, 63430 Less << |
| NCT02023086 | - | Completed | - | Canada, Quebec ... More >> Universite de Montreal Montreal, Quebec, Canada, H3T1P1 Less << | |
| NCT02280135 | Retinitis Pigmentosa | Phase 1 | Completed | - | Spain ... More >> Clinical Universitary Hospital Virgen de la Arrixaca El Palmar, Murcia, Spain, 30120 Less << |
| NCT00761137 | Sialorrhea Secondary to Parkin... More >>son's Disease Less << | Phase 2 | Completed | - | Argentina ... More >> FLENI Hospital Buenos Aires, Argentina Less << |
| NCT00761137 | - | Completed | - | - | |
| NCT03139708 | Intraocular Pressure | Phase 1 | Completed | - | United States, North Carolina ... More >> Wake Forest Baptist Health Eye Center Winston-Salem, North Carolina, United States, 27157 Less << |
| NCT00541177 | Myopia | Phase 4 | Unknown | March 2008 | Taiwan ... More >> Min-Sheng General Hospital Recruiting Tao-Yuan, Taiwan Less << |
| NCT00877175 | Preterm Infants | Phase 4 | Completed | - | Thailand ... More >> Srinagarind Hospital Khon Kaen, Thailand, 40002 Less << |
| NCT03448640 | - | Completed | - | - | |
| NCT02101359 | - | Completed | - | - | |
| NCT00642135 | Retinal Anomalies ... More >> Premature Birth Less << | Phase 3 | Terminated(The total number of... More >> patients has been reached.) Less << | June 2008 | France ... More >> Hôpital Robert Debré Paris, France, 75019 Less << |
| NCT02177539 | Refractive Errors | Phase 4 | Unknown | September 2014 | Chile ... More >> Pontificia Universidad Catolica de Chile, Departamento de Oftalmología Recruiting Santiago, Chile Contact: Osvaldo H Berger, MD +56966076844 oberger@uc.cl Sub-Investigator: Pablo Altschwager, MD Principal Investigator: Osvaldo H Berger, MD Principal Investigator: Cristian Salgado, MD Sub-Investigator: Bernardita Alamos, MD Sub-Investigator: Silvia Araneda, MD Less << |
| NCT00120432 | Eye Diseases | Phase 3 | Completed | - | Thailand ... More >> Srinagarind Hospital Khon Kaen, Thailand, 40002 Less << |
| NCT03097198 | Myopia | Not Applicable | Recruiting | December 2018 | China, Zhejiang ... More >> School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University Recruiting Wenzhou, Zhejiang, China, 325027 Contact: Lewei Tang, Doctor +86 15869627364 zhizhezhiwei@163.com Less << |
| NCT03751631 | Mydriasis | Phase 3 | Active, not recruiting | January 2019 | United States, California ... More >> WCCT Cypress, California, United States, 90630 Less << |
| NCT03751098 | Mydriasis | Phase 3 | Recruiting | January 2019 | United States, Texas ... More >> Keystone Research Recruiting Austin, Texas, United States, 78731 Contact: Robert Stapper 512-415-4400 rstapper@keystoneresearchltd.com R&R Research Active, not recruiting San Antonio, Texas, United States, 78229 Less << |
| NCT00690222 | Cataract Phac... More >>oemulsification Mydriasis Pseudoexfoliation Syndrome Less << | Not Applicable | Terminated(Funding) | - | Canada, Nova Scotia ... More >> Capital District Health Authority Halifax, Nova Scotia, Canada, B3H 2Y9 Less << |
| NCT02521116 | Healthy Subjects ... More >> Diabetic Retinopathy Retinal Vein Occlusion Less << | Not Applicable | Completed | - | Austria ... More >> Medical University of Vienna Vienna, Austria, 1090 Less << |
| NCT01844648 | Sialorrhea (Excessive Drooling... More >>) Less << | Phase 2 | Completed | - | France ... More >> Hôpital de la Salpêtrière Paris, Cedrex 13, France, 75651 Hôpital Paul de Viguier Toulouse, Cedrex 9, France, 31059 Hôpital Haut Lévêque Bordeaux, Pessac, France, 33604 Less << |
Tags: Tropicamide | Ro 1-7683 | mAChR | Muscarinic acetylcholine receptor | M4 | muscarinic | acetylcholine | mydriasis | dilation | pupil | cycloplegia | 1508-75-4 |
Precautionary Statements-General | |
| Code | Phrase |
| P101 | If medical advice is needed,have product container or label at hand. |
| P102 | Keep out of reach of children. |
| P103 | Read label before use |
Prevention | |
| Code | Phrase |
| P201 | Obtain special instructions before use. |
| P202 | Do not handle until all safety precautions have been read and understood. |
| P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
| P211 | Do not spray on an open flame or other ignition source. |
| P220 | Keep/Store away from clothing/combustible materials. |
| P221 | Take any precaution to avoid mixing with combustibles |
| P222 | Do not allow contact with air. |
| P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
| P230 | Keep wetted |
| P231 | Handle under inert gas. |
| P232 | Protect from moisture. |
| P233 | Keep container tightly closed. |
| P234 | Keep only in original container. |
| P235 | Keep cool |
| P240 | Ground/bond container and receiving equipment. |
| P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
| P242 | Use only non-sparking tools. |
| P243 | Take precautionary measures against static discharge. |
| P244 | Keep reduction valves free from grease and oil. |
| P250 | Do not subject to grinding/shock/friction. |
| P251 | Pressurized container: Do not pierce or burn, even after use. |
| P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
| P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
| P262 | Do not get in eyes, on skin, or on clothing. |
| P263 | Avoid contact during pregnancy/while nursing. |
| P264 | Wash hands thoroughly after handling. |
| P265 | Wash skin thouroughly after handling. |
| P270 | Do not eat, drink or smoke when using this product. |
| P271 | Use only outdoors or in a well-ventilated area. |
| P272 | Contaminated work clothing should not be allowed out of the workplace. |
| P273 | Avoid release to the environment. |
| P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
| P281 | Use personal protective equipment as required. |
| P282 | Wear cold insulating gloves/face shield/eye protection. |
| P283 | Wear fire/flame resistant/retardant clothing. |
| P284 | Wear respiratory protection. |
| P285 | In case of inadequate ventilation wear respiratory protection. |
| P231 + P232 | Handle under inert gas. Protect from moisture. |
| P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
| Code | Phrase |
| P301 | IF SWALLOWED: |
| P304 | IF INHALED: |
| P305 | IF IN EYES: |
| P306 | IF ON CLOTHING: |
| P307 | IF exposed: |
| P308 | IF exposed or concerned: |
| P309 | IF exposed or if you feel unwell: |
| P310 | Immediately call a POISON CENTER or doctor/physician. |
| P311 | Call a POISON CENTER or doctor/physician. |
| P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
| P313 | Get medical advice/attention. |
| P314 | Get medical advice/attention if you feel unwell. |
| P315 | Get immediate medical advice/attention. |
| P320 | |
| P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
| P321 | |
| P322 | |
| P330 | Rinse mouth. |
| P331 | Do NOT induce vomiting. |
| P332 | IF SKIN irritation occurs: |
| P333 | If skin irritation or rash occurs: |
| P334 | Immerse in cool water/wrap n wet bandages. |
| P335 | Brush off loose particles from skin. |
| P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
| P337 | If eye irritation persists: |
| P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
| P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
| P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
| P342 | If experiencing respiratory symptoms: |
| P350 | Gently wash with plenty of soap and water. |
| P351 | Rinse cautiously with water for several minutes. |
| P352 | Wash with plenty of soap and water. |
| P353 | Rinse skin with water/shower. |
| P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
| P361 | Remove/Take off immediately all contaminated clothing. |
| P362 | Take off contaminated clothing and wash before reuse. |
| P363 | Wash contaminated clothing before reuse. |
| P370 | In case of fire: |
| P371 | In case of major fire and large quantities: |
| P372 | Explosion risk in case of fire. |
| P373 | DO NOT fight fire when fire reaches explosives. |
| P374 | Fight fire with normal precautions from a reasonable distance. |
| P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
| P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
| P378 | |
| P380 | Evacuate area. |
| P381 | Eliminate all ignition sources if safe to do so. |
| P390 | Absorb spillage to prevent material damage. |
| P391 | Collect spillage. Hazardous to the aquatic environment |
| P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
| P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
| P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
| P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
| P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
| P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
| P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
| P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
| P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
| P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
| P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
| P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
| P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
| P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
| P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
| P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
| P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
| P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
| P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
| P370 + P376 | In case of fire: Stop leak if safe to Do so. |
| P370 + P378 | In case of fire: |
| P370 + P380 | In case of fire: Evacuate area. |
| P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
| P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
| Code | Phrase |
| P401 | |
| P402 | Store in a dry place. |
| P403 | Store in a well-ventilated place. |
| P404 | Store in a closed container. |
| P405 | Store locked up. |
| P406 | Store in corrosive resistant/ container with a resistant inner liner. |
| P407 | Maintain air gap between stacks/pallets. |
| P410 | Protect from sunlight. |
| P411 | |
| P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
| P413 | |
| P420 | Store away from other materials. |
| P422 | |
| P402 + P404 | Store in a dry place. Store in a closed container. |
| P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
| P403 + P235 | Store in a well-ventilated place. Keep cool. |
| P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
| P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
| P411 + P235 | Keep cool. |
Disposal | |
| Code | Phrase |
| P501 | Dispose of contents/container to ... |
| P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
| Code | Phrase |
| H200 | Unstable explosive |
| H201 | Explosive; mass explosion hazard |
| H202 | Explosive; severe projection hazard |
| H203 | Explosive; fire, blast or projection hazard |
| H204 | Fire or projection hazard |
| H205 | May mass explode in fire |
| H220 | Extremely flammable gas |
| H221 | Flammable gas |
| H222 | Extremely flammable aerosol |
| H223 | Flammable aerosol |
| H224 | Extremely flammable liquid and vapour |
| H225 | Highly flammable liquid and vapour |
| H226 | Flammable liquid and vapour |
| H227 | Combustible liquid |
| H228 | Flammable solid |
| H229 | Pressurized container: may burst if heated |
| H230 | May react explosively even in the absence of air |
| H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
| H240 | Heating may cause an explosion |
| H241 | Heating may cause a fire or explosion |
| H242 | Heating may cause a fire |
| H250 | Catches fire spontaneously if exposed to air |
| H251 | Self-heating; may catch fire |
| H252 | Self-heating in large quantities; may catch fire |
| H260 | In contact with water releases flammable gases which may ignite spontaneously |
| H261 | In contact with water releases flammable gas |
| H270 | May cause or intensify fire; oxidizer |
| H271 | May cause fire or explosion; strong oxidizer |
| H272 | May intensify fire; oxidizer |
| H280 | Contains gas under pressure; may explode if heated |
| H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
| H290 | May be corrosive to metals |
Health hazards | |
| Code | Phrase |
| H300 | Fatal if swallowed |
| H301 | Toxic if swallowed |
| H302 | Harmful if swallowed |
| H303 | May be harmful if swallowed |
| H304 | May be fatal if swallowed and enters airways |
| H305 | May be harmful if swallowed and enters airways |
| H310 | Fatal in contact with skin |
| H311 | Toxic in contact with skin |
| H312 | Harmful in contact with skin |
| H313 | May be harmful in contact with skin |
| H314 | Causes severe skin burns and eye damage |
| H315 | Causes skin irritation |
| H316 | Causes mild skin irritation |
| H317 | May cause an allergic skin reaction |
| H318 | Causes serious eye damage |
| H319 | Causes serious eye irritation |
| H320 | Causes eye irritation |
| H330 | Fatal if inhaled |
| H331 | Toxic if inhaled |
| H332 | Harmful if inhaled |
| H333 | May be harmful if inhaled |
| H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
| H335 | May cause respiratory irritation |
| H336 | May cause drowsiness or dizziness |
| H340 | May cause genetic defects |
| H341 | Suspected of causing genetic defects |
| H350 | May cause cancer |
| H351 | Suspected of causing cancer |
| H360 | May damage fertility or the unborn child |
| H361 | Suspected of damaging fertility or the unborn child |
| H361d | Suspected of damaging the unborn child |
| H362 | May cause harm to breast-fed children |
| H370 | Causes damage to organs |
| H371 | May cause damage to organs |
| H372 | Causes damage to organs through prolonged or repeated exposure |
| H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
| Code | Phrase |
| H400 | Very toxic to aquatic life |
| H401 | Toxic to aquatic life |
| H402 | Harmful to aquatic life |
| H410 | Very toxic to aquatic life with long-lasting effects |
| H411 | Toxic to aquatic life with long-lasting effects |
| H412 | Harmful to aquatic life with long-lasting effects |
| H413 | May cause long-lasting harmful effects to aquatic life |
| H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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