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Chemical Structure| 89565-68-4 Chemical Structure| 89565-68-4

Structure of Tropisetron
CAS No.: 89565-68-4

Chemical Structure| 89565-68-4

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Tropisetron is a selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor.

Synonyms: SDZ-ICS-930 free base; ICS 205-930; ICF 205-930

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Product Details of Tropisetron

CAS No. :89565-68-4
Formula : C17H20N2O2
M.W : 284.35
SMILES Code : O=C(C1=CNC2=C1C=CC=C2)O[C@H]3C[C@H]4CC[C@H](N4C)C3
Synonyms :
SDZ-ICS-930 free base; ICS 205-930; ICF 205-930
MDL No. :MFCD00864399

Safety of Tropisetron

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of Tropisetron

GPCR

Isoform Comparison

Biological Activity

Target
  • 5-HT3

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT02007798 Brain Neoplasms ... More >> Surgery Less << Not Applicable Unknown December 2014 China, Liaoning ... More >> Yue Yun Recruiting Shenyang, Liaoning, China, 110001 Contact: Yue Yun, Master    008613889168717    crazy_mouse0707@hotmail.com    Principal Investigator: Ling Pei, Ph.D. Less <<
NCT02479581 Valvular Heart Disease Phase 2 Completed - China, Hunan ... More >> Xiangya Hospital of Central South University Changsha, Hunan, China, 410078 Less <<
NCT03071185 Elective Reconstructive Surger... More >>y Pain, Post Operative Less << Not Applicable Recruiting April 30, 2017 China, Liaoning ... More >> School & Hospital of Stomatology, China Medical University Recruiting Shenyang, Liaoning, China, 110002 Contact: xia zhang Less <<
NCT02195921 to Evaluate the Effectiveness ... More >>of Acupucnture in the Management of Chemotherapy-induced Nausea and Vomiting Less << Not Applicable Unknown December 2015 China, Tianjin ... More >> Tianjin University of TCM Recruiting Tianjin, Tianjin, China, 300193 Contact: Guo Yi, Doc    13920921016    tjutcmacupuncture@163.com Less <<
NCT02195908 to Evaluate the Effectiveness ... More >>of Acupucnture in the Management of Chemotherapy-induced Nausea and Vomiting Less << Not Applicable Unknown October 2015 China, Tianjin ... More >> Tianjin University of TCM Recruiting Tianjin, Tianjin, China, 300193 Contact: Guo Yi, Doc    13920921016    tjutcmacupuncture@163.com Less <<
NCT02625181 Postoperative Nausea and Vomit... More >>ing Less << Not Applicable Completed - United States, Tennessee ... More >> Vanderbilt University Medical Center Nashville, Tennessee, United States, 37212 Less <<
NCT03325816 Small Cell Lung Cancer ... More >> Small Cell Lung Cancer Extensive Stage Less << Phase 1 Phase 2 Active, not recruiting December 2022 United States, District of Col... More >>umbia Georgetown Lombardi Comprehensive Cancer Center Washington, District of Columbia, United States, 20007 United States, New Jersey John Theurer Cancer Center at Hackensack University Medical Center Hackensack, New Jersey, United States, 07601 Less <<
NCT01679418 Postoperative Nausea and Vomit... More >>ing Less << Not Applicable Completed - Switzerland ... More >> Kantonsspital Liestal Liestal, Basel-Landschaft, Switzerland, 4410 Less <<
NCT01101529 Nausea Vomiti... More >>ng Less << Phase 2 Completed - Sweden ... More >> Uppsala University Hospital Uppsala, Sweden, 75185 Less <<
NCT01636947 Nausea Vomiti... More >>ng Less << Phase 4 Completed - -
NCT01636947 - Completed - -
NCT01594749 - Completed - -
NCT01594749 Chemotherapy-Induced Nausea an... More >>d Vomiting (CINV) Less << Phase 3 Completed - -
NCT03540537 Quadratus Lumborum Block ... More >> Thoracic Paravertebral Block Postoperative Analgesia Hepatectomy Less << Not Applicable Recruiting December 31, 2020 China, Guangdong ... More >> Nanfang Hospital of Southern Medical University Recruiting Guangzhou, Guangdong, China, 510515 Contact: Tao Tao, MD    0086-18617391219    taotaomzk@smu.edu.cn    Contact: Bingsha Chen, Bachelor    0086-15802031635    1550688601@qq.com Less <<
NCT03061396 Electro-acupuncture ... More >> Chemotherapy-induced Nausea and Vomiting Less << Not Applicable Recruiting May 28, 2018 China, Tianjin ... More >> Tianjin University of TCM Recruiting Tianjin, Tianjin, China, 300193 Contact: Guo Yi, Doc    13920921016    tjutcmacupuncture@163.com Less <<
NCT01298193 Breast Cancer Phase 4 Completed - Spain ... More >> Badalona, Barcelona, Spain, 08208 Alcalá de Henares, Madrid, Spain Alcorcón, Madrid, Spain, 28922 A Coruña, Spain, 15006 A Coruña, Spain, 15009 Barcelona, Spain, 08003 Barcelona, Spain, 08036 Jaén, Spain, 23007 Lleida, Spain Lugo, Spain Madrid, Spain, 28040 Valencia, Spain, 46015 Zaragoza, Spain, 50009 Less <<
NCT01466803 Healthy Phase 1 Completed - Finland ... More >> Turku University Hospital Turku, Finland, 20500 Less <<
NCT03586817 Nausea and Vomiting, Postopera... More >>tive Less << Phase 4 Not yet recruiting August 1, 2019 Brazil ... More >> Hospital Federal de Bonsucesso Rio de Janeiro, Brazil, 21041-030 Less <<
NCT01367808 Pharmacokinetics and Pharmacod... More >>ynamics of Sublingual Buprenorphine Less << Phase 1 Completed - Finland ... More >> Department of Anaesthesiology & Intensive Care Turku, Finland, 21500 Less <<
NCT00003817 Nausea and Vomiting ... More >> Unspecified Adult Solid Tumor, Protocol Specific Less << Phase 2 Completed - United States, New Jersey ... More >> Hackensack University Medical Center Hackensack, New Jersey, United States, 07601 United States, New York University of Rochester Cancer Center Rochester, New York, United States, 14642 Less <<
NCT02478047 Chemotherapy-induced Nausea an... More >>d Vomiting Less << Not Applicable Unknown September 2016 China, Tianjin ... More >> Tianjin University of TCM Not yet recruiting Tianjin, Tianjin, China, 300193 Contact: Guo Yi, Doc    13920921016    tjutcmacupuncture@163.com Less <<
NCT02576327 Vomiting Phase 4 Unknown December 2017 -
NCT01843868 Lymphoma, Non-Hodgkin Not Applicable Unknown December 2015 -
NCT02909478 Chemotherapy-induced Nausea an... More >>d Vomiting Colorectal Cancer Less << Phase 3 Unknown - -
NCT00970450 Analgesia Not Applicable Completed - Switzerland ... More >> University Hospital of Basel Basel, Switzerland, 4031 Less <<
NCT01304953 Pain, Postoperative Phase 4 Completed - China, Hubei ... More >> Tongji Hospital Wuhan, Hubei, China, 430030 Less <<
NCT03571126 Chemotherapy-induced Nausea an... More >>d Vomiting Lung Cancer Less << Phase 4 Not yet recruiting June 1, 2020 -
NCT01226381 Healthy Volunteers Phase 1 Completed - France ... More >> CHU Clermont-Ferrand Clermont-Ferrand, France, 63003 Less <<
NCT02096835 - Completed - -
NCT00435370 Smoking Cessation ... More >> Schizophrenia Less << Phase 3 Completed - United States, Texas ... More >> Baylor College of Medicine - Michael E. DeBakey VA Medical Center Houston, Texas, United States, 77030 China Beijing Hui-Long Guan Hospital Beijing, China Less <<
NCT00487110 Pain Phase 4 Completed - France ... More >> CHU Clermont-Ferrand, France, 63000 Less <<
NCT02096835 Postoperative Nausea and Vomit... More >>ing Less << Not Applicable Completed - China, Shanghai ... More >> Department of Anesthesiology, North Institute of Huashan Hospital,Fudan University Shanghai, Shanghai, China, 201907 Less <<
NCT00889499 Pain Chronic ... More >>Disease Less << Phase 2 Completed - Switzerland ... More >> Dep. of Anesthesiology and Pain Therapy, Bern University Hospital, Inselspital Bern, Switzerland, 3010 Less <<
NCT01895010 Nausea Vomiti... More >>ng Metastatic Liver Cancer Less << Phase 2 Unknown December 2014 China, Shanghai ... More >> Shanghai Cancer Center Recruiting Shanghai, Shanghai, China, 200032 Contact: Xiaoyan Zhu, Dotral    +08602164175590 ext 3625    zhuxiaoyan@fudan.edu.cn    Principal Investigator: Xiaoyan Zhu, doc Less <<
NCT00435370 - Completed - -

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.52mL

0.70mL

0.35mL

17.58mL

3.52mL

1.76mL

35.17mL

7.03mL

3.52mL

References

 

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