Structure of Tropisetron
CAS No.: 89565-68-4
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Tropisetron is a selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.1 ± 0.9 nM for 5-HT3 receptor.
Synonyms: SDZ-ICS-930 free base; ICS 205-930; ICF 205-930
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CAS No. : | 89565-68-4 |
Formula : | C17H20N2O2 |
M.W : | 284.35 |
SMILES Code : | O=C(C1=CNC2=C1C=CC=C2)O[C@H]3C[C@H]4CC[C@H](N4C)C3 |
Synonyms : |
SDZ-ICS-930 free base; ICS 205-930; ICF 205-930
|
MDL No. : | MFCD00864399 |
GHS Pictogram: |
![]() |
Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
Target |
|
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT02007798 | Brain Neoplasms ... More >> Surgery Less << | Not Applicable | Unknown | December 2014 | China, Liaoning ... More >> Yue Yun Recruiting Shenyang, Liaoning, China, 110001 Contact: Yue Yun, Master 008613889168717 crazy_mouse0707@hotmail.com Principal Investigator: Ling Pei, Ph.D. Less << |
NCT02479581 | Valvular Heart Disease | Phase 2 | Completed | - | China, Hunan ... More >> Xiangya Hospital of Central South University Changsha, Hunan, China, 410078 Less << |
NCT03071185 | Elective Reconstructive Surger... More >>y Pain, Post Operative Less << | Not Applicable | Recruiting | April 30, 2017 | China, Liaoning ... More >> School & Hospital of Stomatology, China Medical University Recruiting Shenyang, Liaoning, China, 110002 Contact: xia zhang Less << |
NCT02195921 | to Evaluate the Effectiveness ... More >>of Acupucnture in the Management of Chemotherapy-induced Nausea and Vomiting Less << | Not Applicable | Unknown | December 2015 | China, Tianjin ... More >> Tianjin University of TCM Recruiting Tianjin, Tianjin, China, 300193 Contact: Guo Yi, Doc 13920921016 tjutcmacupuncture@163.com Less << |
NCT02195908 | to Evaluate the Effectiveness ... More >>of Acupucnture in the Management of Chemotherapy-induced Nausea and Vomiting Less << | Not Applicable | Unknown | October 2015 | China, Tianjin ... More >> Tianjin University of TCM Recruiting Tianjin, Tianjin, China, 300193 Contact: Guo Yi, Doc 13920921016 tjutcmacupuncture@163.com Less << |
NCT02625181 | Postoperative Nausea and Vomit... More >>ing Less << | Not Applicable | Completed | - | United States, Tennessee ... More >> Vanderbilt University Medical Center Nashville, Tennessee, United States, 37212 Less << |
NCT03325816 | Small Cell Lung Cancer ... More >> Small Cell Lung Cancer Extensive Stage Less << | Phase 1 Phase 2 | Active, not recruiting | December 2022 | United States, District of Col... More >>umbia Georgetown Lombardi Comprehensive Cancer Center Washington, District of Columbia, United States, 20007 United States, New Jersey John Theurer Cancer Center at Hackensack University Medical Center Hackensack, New Jersey, United States, 07601 Less << |
NCT01679418 | Postoperative Nausea and Vomit... More >>ing Less << | Not Applicable | Completed | - | Switzerland ... More >> Kantonsspital Liestal Liestal, Basel-Landschaft, Switzerland, 4410 Less << |
NCT01101529 | Nausea Vomiti... More >>ng Less << | Phase 2 | Completed | - | Sweden ... More >> Uppsala University Hospital Uppsala, Sweden, 75185 Less << |
NCT01636947 | Nausea Vomiti... More >>ng Less << | Phase 4 | Completed | - | - |
NCT01636947 | - | Completed | - | - | |
NCT01594749 | - | Completed | - | - | |
NCT01594749 | Chemotherapy-Induced Nausea an... More >>d Vomiting (CINV) Less << | Phase 3 | Completed | - | - |
NCT03540537 | Quadratus Lumborum Block ... More >> Thoracic Paravertebral Block Postoperative Analgesia Hepatectomy Less << | Not Applicable | Recruiting | December 31, 2020 | China, Guangdong ... More >> Nanfang Hospital of Southern Medical University Recruiting Guangzhou, Guangdong, China, 510515 Contact: Tao Tao, MD 0086-18617391219 taotaomzk@smu.edu.cn Contact: Bingsha Chen, Bachelor 0086-15802031635 1550688601@qq.com Less << |
NCT03061396 | Electro-acupuncture ... More >> Chemotherapy-induced Nausea and Vomiting Less << | Not Applicable | Recruiting | May 28, 2018 | China, Tianjin ... More >> Tianjin University of TCM Recruiting Tianjin, Tianjin, China, 300193 Contact: Guo Yi, Doc 13920921016 tjutcmacupuncture@163.com Less << |
NCT01298193 | Breast Cancer | Phase 4 | Completed | - | Spain ... More >> Badalona, Barcelona, Spain, 08208 Alcalá de Henares, Madrid, Spain Alcorcón, Madrid, Spain, 28922 A Coruña, Spain, 15006 A Coruña, Spain, 15009 Barcelona, Spain, 08003 Barcelona, Spain, 08036 Jaén, Spain, 23007 Lleida, Spain Lugo, Spain Madrid, Spain, 28040 Valencia, Spain, 46015 Zaragoza, Spain, 50009 Less << |
NCT01466803 | Healthy | Phase 1 | Completed | - | Finland ... More >> Turku University Hospital Turku, Finland, 20500 Less << |
NCT03586817 | Nausea and Vomiting, Postopera... More >>tive Less << | Phase 4 | Not yet recruiting | August 1, 2019 | Brazil ... More >> Hospital Federal de Bonsucesso Rio de Janeiro, Brazil, 21041-030 Less << |
NCT01367808 | Pharmacokinetics and Pharmacod... More >>ynamics of Sublingual Buprenorphine Less << | Phase 1 | Completed | - | Finland ... More >> Department of Anaesthesiology & Intensive Care Turku, Finland, 21500 Less << |
NCT00003817 | Nausea and Vomiting ... More >> Unspecified Adult Solid Tumor, Protocol Specific Less << | Phase 2 | Completed | - | United States, New Jersey ... More >> Hackensack University Medical Center Hackensack, New Jersey, United States, 07601 United States, New York University of Rochester Cancer Center Rochester, New York, United States, 14642 Less << |
NCT02478047 | Chemotherapy-induced Nausea an... More >>d Vomiting Less << | Not Applicable | Unknown | September 2016 | China, Tianjin ... More >> Tianjin University of TCM Not yet recruiting Tianjin, Tianjin, China, 300193 Contact: Guo Yi, Doc 13920921016 tjutcmacupuncture@163.com Less << |
NCT02576327 | Vomiting | Phase 4 | Unknown | December 2017 | - |
NCT01843868 | Lymphoma, Non-Hodgkin | Not Applicable | Unknown | December 2015 | - |
NCT02909478 | Chemotherapy-induced Nausea an... More >>d Vomiting Colorectal Cancer Less << | Phase 3 | Unknown | - | - |
NCT00970450 | Analgesia | Not Applicable | Completed | - | Switzerland ... More >> University Hospital of Basel Basel, Switzerland, 4031 Less << |
NCT01304953 | Pain, Postoperative | Phase 4 | Completed | - | China, Hubei ... More >> Tongji Hospital Wuhan, Hubei, China, 430030 Less << |
NCT03571126 | Chemotherapy-induced Nausea an... More >>d Vomiting Lung Cancer Less << | Phase 4 | Not yet recruiting | June 1, 2020 | - |
NCT01226381 | Healthy Volunteers | Phase 1 | Completed | - | France ... More >> CHU Clermont-Ferrand Clermont-Ferrand, France, 63003 Less << |
NCT02096835 | - | Completed | - | - | |
NCT00435370 | Smoking Cessation ... More >> Schizophrenia Less << | Phase 3 | Completed | - | United States, Texas ... More >> Baylor College of Medicine - Michael E. DeBakey VA Medical Center Houston, Texas, United States, 77030 China Beijing Hui-Long Guan Hospital Beijing, China Less << |
NCT00487110 | Pain | Phase 4 | Completed | - | France ... More >> CHU Clermont-Ferrand, France, 63000 Less << |
NCT02096835 | Postoperative Nausea and Vomit... More >>ing Less << | Not Applicable | Completed | - | China, Shanghai ... More >> Department of Anesthesiology, North Institute of Huashan Hospital,Fudan University Shanghai, Shanghai, China, 201907 Less << |
NCT00889499 | Pain Chronic ... More >>Disease Less << | Phase 2 | Completed | - | Switzerland ... More >> Dep. of Anesthesiology and Pain Therapy, Bern University Hospital, Inselspital Bern, Switzerland, 3010 Less << |
NCT01895010 | Nausea Vomiti... More >>ng Metastatic Liver Cancer Less << | Phase 2 | Unknown | December 2014 | China, Shanghai ... More >> Shanghai Cancer Center Recruiting Shanghai, Shanghai, China, 200032 Contact: Xiaoyan Zhu, Dotral +08602164175590 ext 3625 zhuxiaoyan@fudan.edu.cn Principal Investigator: Xiaoyan Zhu, doc Less << |
NCT00435370 | - | Completed | - | - |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
3.52mL 0.70mL 0.35mL |
17.58mL 3.52mL 1.76mL |
35.17mL 7.03mL 3.52mL |
Tags: Tropisetron | SDZ-ICS-930 free base | Aliphatic Cyclic Hydrocarbons | 5-HT Receptor | Organic Building Blocks | Neuronal Signaling | GPCR/G Protein | 89565-68-4
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P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
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P234 | Keep only in original container. |
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P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
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P321 | |
P322 | |
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P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
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P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
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H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
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H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
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H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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