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Chemical Structure| 667427-75-0 Chemical Structure| 667427-75-0

Structure of TRPC6-PAM-C20
CAS No.: 667427-75-0

Chemical Structure| 667427-75-0

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TRPC6-PAM-C20 is a selective positive allosteric modulator of the TRPC6 channel, enhancing TRPC6 ion channel activation induced by low concentrations of DAG. In HEK293 cells expressing TRPC6, it induces an increase in Ca2+ concentration with an EC50 of 2.37 μM, suitable for studies amplifying TRPC6-dependent signaling.

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Product Details of TRPC6-PAM-C20

CAS No. :667427-75-0
Formula : C22H21NO4
M.W : 363.41
SMILES Code : O=C1C(C2=NC(C)(CC3=C2C=C(C(OC)=C3)OC)C)=CC4=CC=CC=C4O1
MDL No. :MFCD03661520
InChI Key :SNICUMZYPOCXCO-UHFFFAOYSA-N
Pubchem ID :1081484

Safety of TRPC6-PAM-C20

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Isoform Comparison

Biological Activity

Description
TRPC6-PAM-C20 functions as a selective positive allosteric modulator (PAM) for TRPC6 channels, enhancing channel activation by enabling low basal concentrations of DAG to induce activation. In TRPC6-expressing HEK293 cells, TRPC6-PAM-C20 induces intracellular Ca2+ concentration ([Ca2+]i) increases with an EC50 of 2.37 μM. It serves as a valuable tool for selectively amplifying TRPC6-dependent signals [1].

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Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.75mL

0.55mL

0.28mL

13.76mL

2.75mL

1.38mL

27.52mL

5.50mL

2.75mL

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