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Chemical Structure| 953778-63-7 Chemical Structure| 953778-63-7

Structure of TTA-A2
CAS No.: 953778-63-7

Chemical Structure| 953778-63-7

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TTA-A2 is a potent, selective, orally active T-type calcium channel (Cav3.1 and Cav3.2) antagonist with IC50 values of 89 nM and 92 nM, capable of reducing PXR activation, suitable for studying various neurological diseases, such as sleep disorders and epilepsy.

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Product Details of TTA-A2

CAS No. :953778-63-7
Formula : C20H21F3N2O2
M.W : 378.39
SMILES Code : O=C(N[C@@H](C1=NC=C(OCC(F)(F)F)C=C1)C)CC2=CC=C(C3CC3)C=C2
MDL No. :MFCD16628062
InChI Key :GEYDMBNDOVPFJL-CYBMUJFWSA-N
Pubchem ID :53317097

Safety of TTA-A2

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Isoform Comparison

Biological Activity

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Guinea pigs Nocifensive response model to bladder distension Intravenous injection 3 mg/kg Single administration TTA-A2 significantly reduced nocifensive responses to bladder distension, decreasing the electromyography (EMG) response of abdominal muscles. Pain. 2023 May 1;164(5):1012-1026

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.64mL

0.53mL

0.26mL

13.21mL

2.64mL

1.32mL

26.43mL

5.29mL

2.64mL

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