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Chemical Structure| 345615-74-9 Chemical Structure| 345615-74-9

Structure of Tyrosine kinase-IN-7
CAS No.: 345615-74-9

Chemical Structure| 345615-74-9

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Tyrosine kinase-IN-7 is an EGFR tyrosine kinase inhibitor with IC50 values of 0.630 μM and 0.956 μM for EGFR(WT) and EGFR(T790M), respectively. It exhibits antitumor activity against HepG2, HCT-116, MCF-7, and A431 cancer cell lines with IC50 values of 13.02 μM, 10.14 μM, 12.68 μM, and 47.05 μM, respectively.

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Product Details of Tyrosine kinase-IN-7

CAS No. :345615-74-9
Formula : C16H15N3OS
M.W : 297.37
SMILES Code : OC1=CC=C(C=C1)NC2=NC=NC3=C2C4=C(S3)CCCC4

Safety of Tyrosine kinase-IN-7

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of Tyrosine kinase-IN-7

RTK
JAK-STAT

Isoform Comparison

Biological Activity

Description
Tyrosine kinase-IN-7 is an inhibitor of the EGFR tyrosine kinase, with IC50s of 0.630 μM against EGFR(WT) and 0.956 μM against EGFR(T790M), displaying anticancer effects on four different cancer cell lines (HepG2, HCT-116, MCF-7, and A431) with IC50 values of 13.02 μM, 10.14 μM, 12.68 μM, and 47.05 μM, respectively[1].

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3.36mL

0.67mL

0.34mL

16.81mL

3.36mL

1.68mL

33.63mL

6.73mL

3.36mL

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