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Chemical Structure| 1000023-04-0 Chemical Structure| 1000023-04-0

Structure of Voruciclib
CAS No.: 1000023-04-0

Chemical Structure| 1000023-04-0

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Voruciclib is a protein kinase inhibitor specific for the cyclin-dependent kinase 4 (CDK4) with potential antineoplastic activity.

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Product Details of Voruciclib

CAS No. :1000023-04-0
Formula : C22H19ClF3NO5
M.W : 469.84
SMILES Code : O=C1C=C(C2=CC=C(C(F)(F)F)C=C2Cl)OC3=C1C(O)=CC(O)=C3[C@H]4[C@H](CO)N(C)CC4
MDL No. :MFCD28386202
InChI Key :MRPGRAKIAJJGMM-OCCSQVGLSA-N
Pubchem ID :67409219

Safety of Voruciclib

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of Voruciclib

Hedgehog

Isoform Comparison

Biological Activity

Description
Voruciclib is an orally active and selective CDK inhibitor with Ki values ranging from 0.626 nM to 9.1 nM. It effectively inhibits CDK9, the transcriptional regulator of MCL-1, and suppresses MCL-1 expression in various diffuse large B-cell lymphoma (DLBCL) models [1].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.13mL

0.43mL

0.21mL

10.64mL

2.13mL

1.06mL

21.28mL

4.26mL

2.13mL

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