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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 409351-28-6 Chemical Structure| 409351-28-6

Structure of VU0152100
CAS No.: 409351-28-6

Chemical Structure| 409351-28-6

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VU 0152100 is a potent and selective allosteric potentiator of M4 mAChR with an EC50 of 380 ± 93 nM.

Synonyms: VU152100

4.5 *For Research Use Only !

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Product Details of VU0152100

CAS No. :409351-28-6
Formula : C18H19N3O2S
M.W : 341.43
SMILES Code : O=C(C1=C(N)C2=C(C)C=C(C)N=C2S1)NCC3=CC=C(OC)C=C3
Synonyms :
VU152100
MDL No. :MFCD02742972
InChI Key :MDNWGCQSCGNTKH-UHFFFAOYSA-N
Pubchem ID :864492

Safety of VU0152100

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H319
Precautionary Statements:P301+P310-P305+P351+P338
Class:6.1
UN#:2811
Packing Group:

Isoform Comparison

Biological Activity

Description
VU0152100 (VU152100) is a highly selective mAChR positive allosteric modulator that crosses the blood-brain barrier. It counteracts Amphetamine-induced hypermotility in rats and elevates extracellular dopamine levels in the nucleus accumbens and caudate-putamen. VU0152100 shows significant research potential for treating psychosis and cognitive impairment related to mental disorders like schizophrenia[1][2].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.93mL

0.59mL

0.29mL

14.64mL

2.93mL

1.46mL

29.29mL

5.86mL

2.93mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

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