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Type HazMat fee for 500 gram (Estimated)
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Chemical Structure| 633283-39-3 Chemical Structure| 633283-39-3

Structure of VU10010
CAS No.: 633283-39-3

Chemical Structure| 633283-39-3

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VU 10010 is a selective allosteric potentiator of M4 acetylcholine receptor.

Synonyms: VU10010

4.5 *For Research Use Only !

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Product Details of VU10010

CAS No. :633283-39-3
Formula : C17H16ClN3OS
M.W : 345.85
SMILES Code : O=C(C1=C(N)C2=C(C)C=C(C)N=C2S1)NCC3=CC=C(Cl)C=C3
Synonyms :
VU10010
MDL No. :MFCD03821022
InChI Key :FPRULFHDSFKYBV-UHFFFAOYSA-N
Pubchem ID :714286

Safety of VU10010

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H319
Precautionary Statements:P264-P270-P280-P301+P310+P330-P305+P351+P338-P337+P313-P405-P501
Class:6.1
UN#:2811
Packing Group:

Isoform Comparison

Biological Activity

Description
VU10010 is a potent, highly selective allosteric enhancer of the M4 muscarinic acetylcholine receptor (mAChR) with an EC50 of 400 nM. It binds to an allosteric site on the M4 mAChR, enhancing its affinity for acetylcholine and improving its coupling to G proteins. VU10010 amplifies carbachol-induced suppression of synaptic transmission at excitatory, but not inhibitory, synapses in the hippocampus[1].

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Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.89mL

0.58mL

0.29mL

14.46mL

2.89mL

1.45mL

28.91mL

5.78mL

2.89mL

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