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Chemical Structure| 78954-23-1 Chemical Structure| 78954-23-1

Structure of Yakuchinone A
CAS No.: 78954-23-1

Chemical Structure| 78954-23-1

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Yakuchinone A, derived from Alpinia oxyphylla, has pro-apoptotic activity and shows promising prospects in cancer and anti-inflammatory research.

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Product Details of Yakuchinone A

CAS No. :78954-23-1
Formula : C20H24O3
M.W : 312.40
SMILES Code : O=C(CCCCC1=CC=CC=C1)CCC2=CC=C(O)C(OC)=C2
MDL No. :MFCD30533823

Safety of Yakuchinone A

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of Yakuchinone A

pyroptosis

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
HepG2 cells 3, 10, 30 µM 12 hours To evaluate the protective effect of Yakuchinone A against t-BHP-induced toxicity in HepG2 cells. Results showed that Yakuchinone A significantly increased cell viability to 89.0% at 30 μM concentration. Antioxidants (Basel). 2022 May 23;11(5):1032

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
HRM2 nude mice UV-B-irradiated skin hyperpigmentation model Topical application 0.5% Twice daily for 17 days To investigate the preventive effect of Yakuchinone A on UV-B-irradiated skin hyperpigmentation. Results showed that Yakuchinone A significantly inhibited UV-B-induced skin hyperpigmentation and restored the lightening index of the skin. Int J Biol Sci. 2024 Jan 1;20(1):312-330

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.20mL

0.64mL

0.32mL

16.01mL

3.20mL

1.60mL

32.01mL

6.40mL

3.20mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2
 

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