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Chemical Structure| 2172617-15-9 Chemical Structure| 2172617-15-9

Structure of YKL-06-061
CAS No.: 2172617-15-9

Chemical Structure| 2172617-15-9

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YKL 06-061 is a pan-SIK inhibitor with IC50 values of 6.56nM, 1.77nM and 20.5nM for SIK1, SIK2 and SIK3, respectively.

Synonyms: YKL-06-061

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Product Details of YKL-06-061

CAS No. :2172617-15-9
Formula : C30H37N7O2
M.W : 527.66
SMILES Code : O=C1N(C2CCC2)C3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4OC)=NC=C3CN1C6=C(C)C=CC=C6C
Synonyms :
YKL-06-061
MDL No. :MFCD32173438
InChI Key :GVBAXIVNAHMIGH-UHFFFAOYSA-N
Pubchem ID :132992144

Safety of YKL-06-061

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
Mouse melanoma B16F0 cells 3 µM ARN 3236 or 1 µM YKL 06-061 72 hours To investigate the inhibitory effect of Yakuchinone A on SIK inhibitor-induced melanogenesis. Results showed that Yakuchinone A inhibited melanin production in SIK inhibitor-activated B16F0 cells. Int J Biol Sci. 2024 Jan 1;20(1):312-330

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
C57BL/6J mice PTZ-induced epilepsy model Intraperitoneal injection 10, 20, or 40 mg/kg 7 days YKL-06-061 decreased seizure activity and prevented neuronal overactivity Brain Behav. 2023 Dec;13(12):e3305

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.90mL

0.38mL

0.19mL

9.48mL

1.90mL

0.95mL

18.95mL

3.79mL

1.90mL

References

 

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