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Chemical Structure| 873436-91-0 Chemical Structure| 873436-91-0

Structure of Zelavespib
CAS No.: 873436-91-0

Chemical Structure| 873436-91-0

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PU-H71 is a potent Hsp90 inhibitor with IC50 of 50 nM.

Synonyms: Pu-h 71; NSC 750424; PU-H71

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Product Details of Zelavespib

CAS No. :873436-91-0
Formula : C18H21IN6O2S
M.W : 512.37
SMILES Code : NC1=C2N=C(SC3=C(I)C=C(OCO4)C4=C3)N(CCCNC(C)C)C2=NC=N1
Synonyms :
Pu-h 71; NSC 750424; PU-H71
MDL No. :MFCD18251588
InChI Key :SUPVGFZUWFMATN-UHFFFAOYSA-N
Pubchem ID :9549213

Safety of Zelavespib

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Related Pathways of Zelavespib

DNA

Isoform Comparison

Biological Activity

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Athymic nude mice MDA-MB-468 tumor xenograft model Intravenous injection 50 mg/kg Single dose, observation up to 72 hours To investigate the pharmacokinetics and target occupancy of Zelavespib in vivo, and its modulation effect on epichaperome. Results showed that Zelavespib has a long residence time in tumors and its binding to epichaperome leads to its disassembly. PMC10604720

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.95mL

0.39mL

0.20mL

9.76mL

1.95mL

0.98mL

19.52mL

3.90mL

1.95mL

References

 

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