CAS No. :	122-48-5
Formula :	C₁₁H₁₄O₃
M.W :	194.23
SMILES Code :	CC(CCC1=CC=C(O)C(OC)=C1)=O
Synonyms :	Vanillylacetone; Gingerone; AI3-31837
MDL No. :	MFCD00048232
InChI Key :	OJYLAHXKWMRDGS-UHFFFAOYSA-N
Pubchem ID :	31211

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H315-H319-H335
Precautionary Statements:	P261-P280-P305+P351+P338-P304+P340-P405-P501

HaCaT keratinocytes	100-200 μg/mL	0.5 or 3 hours	Assessed cell viability under oxidative stress; THDC alone did not rescue viability, but THDC+AZ combination fully protected against H2O2-induced cell death	Int J Mol Sci. 2021 Aug 15;22(16):8756
THP-1 macrophages	40 µM	24 hours	To investigate the effect of zingerone on A. actinomycetemcomitans-induced NO production, results showed that zingerone significantly suppressed NO production.	Biomedicines. 2023 Jul 28;11(8):2130
THP-1 macrophages	10-80 µM	24 hours	To assess the cytotoxic effect of zingerone on THP-1 macrophages, results showed that zingerone did not induce any cytotoxicity at any concentration.	Biomedicines. 2023 Jul 28;11(8):2130
Neonatal rat cardiomyocytes (NRCMs)	50 and 250 µM	24 hours	Zingerone significantly suppressed PE-induced cardiomyocyte hypertrophy, reduced ANP and β-MHC mRNA expression levels, and decreased cell surface area.	J Cell Mol Med. 2019 Sep;23(9):6466-6478
BE(2)-M17 cells	0.25 to 2 mM	24 or 48 hours	Zingerone significantly suppressed cell viability in a dose-dependent manner; long-term treatment reduced colony-forming ability	Int J Mol Sci. 2018 Sep 19;19(9):2832
BE(2)C cells	0.25 to 2 mM	24 or 48 hours	Zingerone significantly suppressed cell viability in a dose-dependent manner	Int J Mol Sci. 2018 Sep 19;19(9):2832
SH-SY5Y cells	0.25 to 2 mM	24 or 48 hours	Zingerone significantly suppressed cell viability in a dose-dependent manner	Int J Mol Sci. 2018 Sep 19;19(9):2832
RAW264.7 macrophage cells	200 µM	5 days	To evaluate the effect of Zingerone on RAW264.7 cell differentiation. Results showed that Zingerone significantly inhibited osteoclast differentiation, as evidenced by reduced TRAP staining and activity (p < 0.05).	Metabolites. 2024 Dec 9;14(12):693
SAOS-2 osteosarcoma cells	200 µM	7 and 14 days	To evaluate the effect of Zingerone on SAOS-2 cell differentiation. Results showed that Zingerone significantly stimulated the gene expression of ALP and Runx2 (p < 0.05) but did not significantly enhance SAOS-2 mineralisation.	Metabolites. 2024 Dec 9;14(12):693

BALB/c mice	Renca cell-induced tumor model	Intraperitoneal injection	10 mg/kg	Once daily for one week	Zingerone significantly reduced tumor volume, decreased cyclin D1 expression, increased pH3-positive cells and apoptotic cells	Int J Mol Sci. 2018 Sep 19;19(9):2832
C57BL/6 mice	CFA-induced inflammatory pain model	Intraperitoneal injection	10 mg/kg or 20 mg/kg	Single dose or daily administration for 14 days	To assess the analgesic effects of Zingerone on inflammatory pain, results showed that Zingerone significantly increased mechanical and thermal pain thresholds and reduced calcium signal activity in ACC neurons.	Front Pharmacol. 2025 Mar 11;16:1543594
Male C57/B6J mice	Aortic banding (AB) surgery-induced cardiac remodelling model	Intragastric administration	10 or 20 mg/kg/day	Once daily for 25 days	Zingerone significantly suppressed AB surgery-induced cardiac hypertrophy, fibrosis, oxidative stress and inflammation, and improved cardiac function.	J Cell Mol Med. 2019 Sep;23(9):6466-6478
BALB/c mice	Pseudomonas aeruginosa peritonitis model	Intraperitoneal	100 mg/kg	Single dose	To evaluate the hepatoprotective potential of zingerone against liver inflammation induced by antibiotic mediated endotoxemia in a P.aeruginosa peritonitis model. Results showed that zingerone significantly reduced liver inflammatory response, improved liver histology, and decreased levels of inflammatory markers (MDA, RNI, MPO) and cytokines (MIP-2, IL-6, and TNF-α).	PLoS One. 2014 Sep 3;9(9):e106536
Wistar rats	LPS-induced endotoxemia	Oral	150 mg/kg	Administered 2 h before LPS challenge and monitored up to 96 h post LPS treatment	To evaluate the protective effect of Zingerone (ZIN) against lipopolysaccharide-induced oxidative stress, DNA damage, and cytokine storm in rats. Results showed that ZIN treatment significantly (p<0.5) restored plasma enzymes, antioxidant markers, and attenuated plasma proinflammatory cytokines and sepsis biomarker (PCT), thereby preventing multi-organ and tissue damage in LPS-induced rats, also confirmed by histopathological studies of different organs.	Molecules. 2020 Nov 4;25(21):5127
Wistar rats	Streptozotocin-induced diabetic model	Oral	20 mg/kg	Once daily for seven weeks	Zingerone significantly suppressed delayed ventricular repolarization and AV conduction delay in diabetic rats, reducing cardiac fibrosis and inflammation.	PLoS One. 2017 Dec 5;12(12):e0189074
Male swiss albino mice	LiCl-and-pilocarpine-induced epilepsy model	Oral	25 and 50 mg/kg	Once daily for 15 days	Zingerone attenuated seizure activity and protected hippocampal neurons by regulating redox imbalance, inflammation, and apoptosis	Pharmaceuticals (Basel). 2021 Feb 11;14(2):146
Wistar rats	Complete Freund’s adjuvant (FCA)-induced rheumatoid arthritis model	Oral	25 mg/kg	Once daily for 3 weeks	To evaluate the protective role of zingerone in FCA-induced rheumatoid arthritis. Results showed that zingerone significantly reduced the levels of NF-κB, TGF-β, TNF-α, IL-1β, IL-6, and Hs-CRP and markedly increased IL-10 levels. The levels of antioxidant enzymes were also restored.	Redox Rep. 2021 Dec;26(1):62-70
Sprague-Dawley rats	Alcohol-induced fatty liver disease model	Oral	40 mg/kg	Daily administration from postnatal day 12 to 21	To evaluate the long-term protective effect of Zingerone against alcohol-induced fatty liver disease. Results showed that neonatal orally administered Zingerone attenuated alcohol-induced liver lipid accretion and SREBP1c upregulation in male rats only and attenuated the alcohol-induced hepatic PPAR-α downregulation and macrosteatosis in both sexes.	Metabolites. 2023 Jan 23;13(2):167
C57BL/6 mice	A. actinomycetemcomitans-induced periodontitis mice model	Oral gavage	400 mg/kg	Three times weekly for four weeks	To evaluate the effect of zingerone on A. actinomycetemcomitans-induced alveolar bone resorption, results showed that zingerone significantly inhibited alveolar bone resorption.	Biomedicines. 2023 Jul 28;11(8):2130
Wistar male albino rats	Alloxan-induced diabetes model	Oral	50 and 100 mg/kg	Daily for 21 days	Zingerone restrained the alloxan induced oxidative stress by increasing the activity of reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX) and reducing the peroxidative damage. We also confirmed that zingerone suppressed the level of redox-sensitive transcription factor NF-κB and downregulated other downstream inflammatory cytokines like interleukins (IL1-β, IL-2, IL-6) and tumor necrosis factor alpha (TNF-α). Moreover, the experimental findings suggested that zingerone improved the insulin levels.	Saudi Pharm J. 2018 Dec;26(8):1137-1145
Wistar albino rats	Carfilzomib-induced cardiotoxicity model	Oral	50 mg/kg and 100 mg/kg	16 days	Zingerone significantly attenuated the effects of CFZ on oxidative stress by enhancing the antioxidant properties of glutathione (GSH), catalase (CAT), and superoxide dismutase (SOD). Additionally, ZRN reduces inflammatory cytokines and apoptotic markers, such as IL-1β, IL-6, TNFα, and caspase-3. Overall, zingerone prevents carfilzomib-induced cardiotoxicity in rats, as evidenced by histopathological studies.	Int J Mol Sci. 2022 Dec 9;23(24):15617

Bio Calculators
Preparing Stock Solutions		1mg	5mg	10mg
Preparing Stock Solutions	1 mM 5 mM 10 mM	5.15mL 1.03mL 0.51mL	25.74mL 5.15mL 2.57mL	51.49mL 10.30mL 5.15mL
Dissolving Methods	Animal experiment Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn: in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Protocol 1 Protocol 2

{[proInfo.proName]}

CAS No.: 122-48-5

{[proInfo.proName]}

CAS No.: 122-48-5

Alternative Products

Product Details of Zingerone

Safety of Zingerone

Related Pathways of Zingerone

Isoform Comparison

Biological Activity

Protocol

References

Historical Records

Categories

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Molarity Calculator

Total Compounds Calculator

Dissolution Calculator

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed