Structure of Zipalertinib
CAS No.: 1661854-97-2
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Zipalertinib is a novel EGFR mutation inhibitor specifically targeting certain EGFR mutations present in tumors. It has significant potential in treating various EGFR mutation-related cancers, such as non-small cell lung cancer.
Synonyms: TAS6417; CLN-081
4.5
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Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
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CAS No. : | 1661854-97-2 |
Formula : | C23H20N6O |
M.W : | 396.44 |
SMILES Code : | C=CC(N[C@@H]1CN2C3=NC=NC(N)=C3C(C4=CC5=CC=CC=C5N=C4)=C2C(C)=C1)=O |
Synonyms : |
TAS6417; CLN-081
|
MDL No. : | MFCD31715430 |
InChI Key : | MKCYPWYURWOKST-INIZCTEOSA-N |
Pubchem ID : | 117918742 |
GHS Pictogram: |
![]() |
Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H335 |
Precautionary Statements: | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
Target |
|
In Vitro:
Cell Line
|
Concentration | Treated Time | Description | References |
BEAS-2B | 10 μM | 72 h | Evaluate the toxicity of TAS6417 on normal cells, results showed that 10 μM TAS6417 and erlotinib had no impact on BEAS-2B cells | PMC6872223 |
In Vivo:
Species
|
Animal Model
|
Administration | Dosage | Frequency | Description | References |
BALB/cAJcl-nu/nu mice | Subcutaneous implantation model | Oral | 50, 100, 200 mg/kg | Once daily for 10-14 days | Evaluate the inhibitory effect of TAS6417 on EGFR mutations in vivo, results showed that TAS6417 at doses of 50, 100, 200 mg/kg/day significantly inhibited tumor growth | PMC6872223 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT05967689 | Advanced or Metastatic NSCLC H... More >>arboring Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion (ex20ins) Mutations Less << | PHASE2 | ACTIVE_NOT_RECRUITING | 2025-10-20 | O'Neal Comprehensive Cancer Ce... More >>nter at the University of Alabama at Birmingham, Birmingham, Alabama, 35294, United States|City of Hope - Duarte (Main Campus), Duarte, California, 91010, United States|City of Hope - Huntington Beach, Huntington Beach, California, 92648, United States|City of Hope Orange County Lennar Foundation Cancer Center, Irvine, California, 92618, United States|SCRI - Florida Cancer Specialists - East Region Research Office, West Palm Beach, Florida, 33401, United States|Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02115, United States|Comprehensive Cancer Centers of Nevada - Henderson, Henderson, Nevada, 89052, United States|Comprehensive Cancer Centers of Nevada - Horizon Ridge Henderson, Henderson, Nevada, 89052, United States|Comprehensive Cancer Centers of Nevada - Southeast Henderson - Stephanie, Henderson, Nevada, 89074, United States|Comprehensive Cancer Centers of Nevada - Northwest, Las Vegas, Nevada, 89128, United States|Comprehensive Cancer Centers of Nevada - Summerlin Medical Center II, Las Vegas, Nevada, 89144, United States|Comprehensive Cancer Centers of Nevada - Southwest, Las Vegas, Nevada, 89148, United States|Comprehensive Cancer Centers of Nevada - Central Valley - Twain, Las Vegas, Nevada, 89169, United States|Memorial Sloan Kettering Cancer Center - Basking Ridge, Basking Ridge, New Jersey, 07920, United States|Memorial Sloan Kettering Cancer Center - Monmouth, Middletown, New Jersey, 07748, United States|Memorial Sloan Kettering Cancer Center - Bergen, Montvale, New Jersey, 07645, United States|Memorial Sloan Kettering Cancer Center - Commack, Commack, New York, 11725, United States|Memorial Sloan Kettering Cancer Center - Westchester, Harrison, New York, 10604, United States|Memorial Sloan Kettering Cancer Center - New York, New York, New York, 10065, United States|Memorial Sloan Kettering Cancer Center - Nassau, Uniondale, New York, 11553, United States|Gabrail Cancer and Research Center, Canton, Ohio, 44718, United States|SCRI - Mark H. Zangmeister Cancer Center, Columbus, Ohio, 43219, United States|The Toledo Clinic Cancer Center, Toledo, Ohio, 43623, United States|Tennessee Oncology - Nashville - Centennial Clinic - Medical Oncology, Nashville, Tennessee, 37203, United States|University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, United States|Virginia Cancer Specialists - Arlington Office, Arlington, Virginia, 22205, United States|Virginia Cancer Specialists - Fairfax Office, Fairfax, Virginia, 22031, United States|Virginia Cancer Specialists - Gainesville Office, Gainesville, Virginia, 20155, United States|Virginia Cancer Specialists - Reston, Reston, Virginia, 20190, United States|Froedtert and Medical College of Wisconsin, Milwaukee, Wisconsin, 53226, United States|Bankstown-Lidcombe Hospital, Bankstown, New South Wales, 2200, Australia|GenesisCare - North Shore, Saint Leonards, New South Wales, 2065, Australia|Joondalup Health Campus, Joondalup, Western Australia, 6027, Australia|William Osler Health System - Brampton Civic Hospital, Brampton, L6R 3J7, Canada|Les H?pitaux Universitaires de Strasbourg, Strasbourg cedex, Aslace, 67091, France|H?pital C?te De Nacre, Caen cedex 9, Basse-Normandie, 14033, France|Institut Curie, Paris cedex 05, Ile-de-France, 75248, France|Centre Hospitalier Universitaire Limoges, Limoges cedex, Limousin, 87042, France|Centre Hospitalier Universitaire De Nantes - H?pital Nord Laennec, Saint-Herblain, Loire-Atlantique, 44805, France|H?pital Haut-Lévêque, Pessac, Nouvelle-Aquitaine, 33604, France|H?pital Nord de Marseille, Marseille, Provence Alpes Cote d′Azur, 13015, France|Centre Léon Bérard, Lyon, Rhone-Alpes, 69008, France|H?pital Ambroise-Paré, Boulogne-Billancourt, ?le-de-France, 92100, France|Klinikum Kassel, Kassel, Hassen, 34125, Germany|Universit?tsklinikum Gie?en und Marburg - Gie?en, Gie?en, Hessen, 35392, Germany|Universitatsklinikum Carl Gustav Carus Dresden, Dresden, SAchsen, 01301, Germany|Universit?tsklinikum Regensburg, Regensburg, 93053, Germany|Queen Mary Hospital - Hong Kong, Pok Fu Lam, Hong Kong Island, Hong Kong|Azienda Ospedaliero - Universitaria Careggi, Firenze, Florence, 50134, Italy|Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST, Meldola, Forli-Cesena, 47014, Italy|Azienda Socio-Sanitaria Territoriale di Cremona, Cremona, 26100, Italy|Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Ospedale San Raffaele, Milan, 20132, Italy|Azienda Ospedaliero-Universitaria di Parma, Parma, 43126, Italy|Azienda Unità Sanitaria Locale della Romagna, Ravenna, 48121, Italy|Aichi Cancer Center, Nagoya, Aiti, 464-8681, Japan|Kyushu Cancer Center, Fukuoka-shi, Hukuoka, 811-1395, Japan|Sendai Kousei Hospital, Sendai, Miyagi, 980-0873, Japan|Kindai University Hospital, ōsaka-sayama-Shi, Osaka, 589-8511, Japan|Shizuoka Cancer Center, Sunto-gun, Sizuoka, 411-8777, Japan|National Cancer Center Hospital East, Kashiwa-shi, Tiba, 277-8577, Japan|Cancer Institute Hospital of JFCR, Koto, Tokyo, 135-8550, Japan|Niigata Cancer Center Hospital, Niigata, 951-8566, Japan|Okayama University Hospital, Okayama, 700-8558, Japan|National Cancer Center Hospital, Tokyo, 104-0045, Japan|Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-Do, 13620, Korea, Republic of|Catholic University of Korea Saint Vincent's Hospital, Suwon-si, Gyeonggi-do, 16247, Korea, Republic of|Ajou University Hospital, Suwon-si, Gyeonggi-do, 16499, Korea, Republic of|Gyeongsang National University Hospital, Jinju, Gyeongsangnamdo [Kyongsangnam-do], 52727, Korea, Republic of|Inha University Hospital, Incheon, Incheon Gwang'yeogsi [Inch'on-Kwangyokshi], 22332, Korea, Republic of|Chonnam National University Hwasun Hospital, Hwasun, Jeollanam-do, 58128, Korea, Republic of|Asan Medical Center, Seoul, Seoul Teugbyeolsi [Seoul-T'ukpyolshi], 05505, Korea, Republic of|Korea University Guro Hospital, Seoul, Seoul Teugbyeolsi [Seoul-T'ukpyolshi], 08308, Korea, Republic of|The Catholic University of Korea - Seoul St. Mary's Hospital, Soeul, Seoul Teugbyeolsi [Seoul-T'ukpyolshi], 06591, Korea, Republic of|Hospital Regional Universitario de Málaga - Hospital General, Málaga, Malaga, 29010, Spain|Clínica Mi Tres Torres, Barcelona, 08017, Spain|Hospital Quirónsalud Barcelona, Barcelona, 08023, Spain|Hospital Universitario de Jaén, Jaén, 23007, Spain|MD Anderson Cancer Center Madrid, Madrid, 28033, Spain|Hospital Universitario Fundación Jiménez Díaz, Madrid, 28040, Spain|Hospital Universitario 12 de Octubre, Madrid, 28041, Spain|Hospital Universitario La Paz, Madrid, 28046, Spain|T.C. Saglik Bakanligi Ankara Bilkent Sehi?r Hastanesi?, Cankaya, Ankara, 06800, Turkey|Ankara Il Saglik Mudurlugu SBU Gulhane Egitim Ve Arastirma Hastanesi, Etlik, Ankara, 06010, Turkey|Istinye üniversite Hastanesi Liv Hospital Bahcesehir, Esenyurt, Istanbul, 34517, Turkey|Trakya üniversitesi Saglik Arastirma ve Uygulama Merkezi, Edirne, 22030, Turkey|Bagcilar Medipol Mega Universite Hastanesi, Istanbul, 34214, Turkey|T.C. Saglik Bakanligi - Istanbul Il Saglik Mudurlugu - Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi, Istanbul, 34722, Turkey|The Christie NHS Foundation Trust, Manchester, England, M20 4BX, United Kingdom|Nottingham University Hospitals NHS Trust, Nottingham, England, NG5 1PB, United Kingdom Less << |
NCT05973773 | Advanced or Metastatic NSCLS W... More >>ith Exon 20 Insertion Mutation Less << | PHASE3 | RECRUITING | 2026-08-24 | Comprehensive Cancer Centers o... More >>f Nevada - Henderson, Henderson, Nevada, 89052, United States|Comprehensive Cancer Centers of Nevada - Horizon Ridge Henderson, Henderson, Nevada, 89052, United States|Comprehensive Cancer Centers of Nevada - Southeast Henderson - Stephanie, Henderson, Nevada, 89074, United States|Comprehensive Cancer Centers of Nevada - Summerlin Medical Center II, Las Vegas, Nevada, 89144, United States|Comprehensive Cancer Centers of Nevada - Southwest, Las Vegas, Nevada, 89148, United States|Comprehensive Cancer Centers of Nevada - Central Valley - Twain, Las Vegas, Nevada, 89169, United States|Comprehensive Cancer Centers of Nevada - Northwest, Las Vegas, Nevada, 89218, United States|Gabrail Cancer and Research Center, Canton, Ohio, 44718, United States|The Toledo Clinic Cancer Center, Toledo, Ohio, 43623, United States|University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, United States|Universitair Ziekenhuis Leuven - Campus Gasthuisberg, Leuven, Flemish Brabant, 3000, Belgium|Algemeen Ziekenhuis Maria Middelares, Gent, Oost-Vlaaderen, 9000, Belgium|Algemeen Ziekenhuis Delta - Campus Menen, Menen, West Flanders, 8930, Belgium|Algemeen Ziekenhuis Delta - Campus Rumbeke, Rosières, West-Vlaanderen, 8800, Belgium|Centro Regional Integrado de Oncologia, Fortaleza, Ceará, 60335-480, Brazil|Hospital S?o Lucas da PUCRS, Porto Alegre, Rio Grande Do Sul, 90610-000, Brazil|Clínica Neoplasias Litoral, Itajaí, Santa Catatina, 88301, Brazil|Hospital Amaral Carvalho, Jaú, S?o Paulo, 17210-180, Brazil|Multi-profile Hospital for Active Treatment Uni Hospital, Panagyurishte, Pazardzhik, 1527, Bulgaria|University Multiprofile Hospital for Active Treatment Tsaritsa Yoanna-ISUL, Sofia, 4500, Bulgaria|William Osler Health System - Brampton Civic Hospital, Brampton, Ontario, L6R 3J7, Canada|Princess Margaret Cancer Centre, Toronto, Ontario, M5G 2M9, Canada|Les H?pitaux Universitaires de Strasbourg, Strasbourg cedex, Alsace, 67091, France|H?pital C?te De Nacre, Caen cedex 9, Basse-Normandie, 14033, France|Institut Curie, Paris cedex, Ile-de-France, 75248, France|Centre Hospitalier Universitaire Limoges, Limoges, Limousin, 87042, France|H?pital Haut-Lévêque, Pessac, Nouvelle-Aquitaine, 33604, France|Centre Hospitalier Le Mans, Le Mans cedex 9, Pays De La Loire, 72037, France|H?pital Ambroise-Paré, Boulogne-Billancourt, ?le-de-France, 92100, France|Asklepios Klinik Altona, Hamburg, Hamburg (Hansestadt), 22763, Germany|Universit?tsklinikum Gie?en und Marburg - Gie?en, Gie?en, Hessen, 35392, Germany|LMU Klinikum - Campus Innenstadt, München, 80337, Germany|Universit?tsklinikum Regensburg, Regensburg, 93053, Germany|General Hospital for Thoracic Diseases Sotiria, Athens, Attica, 11527, Greece|Metropolitan General, Piraeus, Attica, 18547, Greece|University General Hospital of Patras, Patra, Peloponnese, 26504, Greece|Metropolitan Hospital, Peiraias, Pireas, 185 47, Greece|University General Hospital of Larissa, Larissa, Thessaly, 41110, Greece|BioClinic Thessaloniki, Thessaloniki, 54622, Greece|Emek Medical Center, Afula, 18101, Israel|Shaare Zedek Medical Center, Jerusalem, 9103102, Israel|Hadassah University Hospital Ein Kerem, Jerusalem, 9112001, Israel|Tel Aviv Sourasky Medical Center, Tel Aviv, 6423906, Israel|Assuta Hospital - Ramat HaHayal, Tel aviv, 69710, Israel|Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST, Meldola, Forlì-Cesena, 47014, Italy|Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Ospedale San Raffaele, Milan, 20132, Italy|Azienda Ospedaliero - Universitaria di Modena, Modena, 41224, Italy|Fondazione IRCCS Policlinico San Matteo, Pavia, 27100, Italy|Azienda Unità Sanitaria Locale della Romagna, Ravenna, 48121, Italy|Azienda Ospedaliera Universitaria Integrata Verona, Verona, 37126, Italy|Aichi Cancer Center, Nagoya, Aiti [Aichi], 464-8681, Japan|Hirosaki University Hospital, Hirosaki-Shi, Aomori, 036-8563, Japan|Kyushu Cancer Center, Fukuoka-shi, Hukuoka, 811-1395, Japan|Kitasato University Hospital, Sagamihara, Kanagawa, 252-0375, Japan|Kanagawa Cardiovascular and Respiratory Center, Yokohama, Kanagawa, 236-0051, Japan|Saiseikai Kumamoto Hospital, Kumamoto-Shi, Kumamoto, 861-4163, Japan|Sendai Kousei Hospital, Sendai, Miyagi, 980-0873, Japan|Okayama University Hospital, Okayamashi, Okayama, 700-8558, Japan|Kansai Medical University Hospital, Hirakata, Osaka, 573-1191, Japan|National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai-Shi, Osaka, 591-8555, Japan|Cancer Institute Hospital of JFCR, Koto, Tokyo, 135-8550, Japan|Keio University Hospital, Shinjuku-Ku, Tokyo, 160-8582, Japan|Kanazawa University Hospital, Kanazawa, 920-8641, Japan|Osaka City General Hospital, Osaka, 534-0021, Japan|Osaka Prefectural Hospital Organization - Osaka International Cancer Institute, Osaka, 541-8567, Japan|Catholic University of Korea Saint Vincent's Hospital, Suwon-si, Gyeonggi-do, 16247, Korea, Republic of|Ajou University Hospital, Suwon-si, Gyeonggi-do, 16499, Korea, Republic of|Gyeongsang National University Hospital, Jinju, Gyeongsangnamdo [Kyongsangnam-do], 52727, Korea, Republic of|Inha University Hospital, Incheon, Incheon Gwang'yeogsi [Inch'on-Kwangyokshi], 22332, Korea, Republic of|Korea University Anam Hospital, Seoul, Seoul Teugbyeolsi [Seoul-T'ukpyolshi], 02841, Korea, Republic of|Korea University Guro Hospital, Seoul, Seoul Teugbyeolsi [Seoul-T'ukpyolshi], 08308, Korea, Republic of|Radboud Universitair Medisch Centrum, Nijmegen, Gelderland, 6525 GA, Netherlands|Vrije Universiteit Medisch Centrum, Amsterdam, Noord-Holland, 1081 HV, Netherlands|St. Luke's Medical Center - Quezon City, Quezon City, Metropolitan Manila, 1112, Philippines|Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie, Lublin, Lubelskie, 20-954, Poland|Instytut MSF, ?ód?, Lódzkie, 90-302, Poland|Wielkopolskie Centrum Pulmonologii i Torakochirurgii im. Eugenii i Janusza Zeylandów, Pozna?, Wielkopolskie, 60-569, Poland|Tan Tock Seng Hospital, Singapore, 30433, Singapore|Complejo Hospitalario Universitario A Coru?a, A Coru?a, La Coru?a, 15006, Spain|Clínica Mi Tres Torres, Barcelona, 08017, Spain|Hospital Quirónsalud Barcelona, Barcelona, 08023, Spain|Hospital Clinic de Barcelona, Barcelona, 08036, Spain|Hospital Universitario de Jaén, Jaén, 23007, Spain|MD Anderson Cancer Center Madrid, Madrid, 28033, Spain|Hospital Universitario Fundación Jiménez Díaz, Madrid, 28040, Spain|Hospital Universitario 12 de Octubre, Madrid, 28041, Spain|Hospital Universitario La Paz, Madrid, 28046, Spain|Hospital Regional Universitario de Málaga - Hospital General, Málaga, 29010, Spain|Faculty of Medicine Siriraj Hospital, Bang Phlat, Bangkok, 10700, Thailand|King Chulalongkorn Memorial Hospital, Pathum Wan, Bangkok, 10330, Thailand|Navamindradhiraj University - Faculty of Medicine Vajira Hospital, Krung Thep Maha Nakhon, Khet Dusit, 10300, Thailand|T.C. Saglik Bakanligi Adana Sehir Egitim ve Arastirma Hastanesi, Adana, 01060, Turkey|Medical Park Seyhan Hastanesi, Adana, 01120, Turkey|Hacettepe üniversitesi Kanser Enstitüsü, Ankara, 06010, Turkey|Memorial Ankara Hastanesi, Ankara, 6520, Turkey|Trakya üniversitesi Sa?l?k Ara?t?rma ve Uygulama Merkezi, Edirne, 22130, Turkey|Ankara Il Saglik Mudurlugu SBU Gulhane Egitim Ve Arastirma Hastanesi, Etlik, 06010, Turkey|Bagcilar Medipol Mega Universite Hastanesi, Istanbul, 34214, Turkey|T.C. Saglik Bakanligi - Istanbul Il Saglik Mudurlugu - Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi, Istanbul, 34722, Turkey|T.C. Saglik Bakanligi Ankara Bilkent Sehi?r Hastanesi?, ?ankaya, 06800, Turkey|Royal Free London NHS Foundation Trust, London, England, NW3 2QG, United Kingdom|Nottingham University Hospitals NHS Trust, Nottingham, England, NG5 1PB, United Kingdom|Torbay and South Devon NHS Foundation Trust, Torquay, England, TQ2 7AA, United Kingdom Less << |
NCT04036682 | Non Small Cell Lung Cancer|EGF... More >>R Exon 20 Mutation Less << | PHASE1|PHASE2 | ACTIVE_NOT_RECRUITING | 2025-12-24 | Pacific Cancer Medical Center,... More >> Inc, Anaheim, California, 92801, United States|City of Hope Comprehensive Cancer Center, Duarte, California, 91010, United States|City of Hope at Irvine Lennar, Irvine, California, 92618, United States|Pacific Shores Medical Group, Long Beach, California, 90813, United States|AdventHealth, Orlando, Florida, 32804, United States|Massachusetts General Hospital, Boston, Massachusetts, 02114, United States|University of Michigan Health System - University Hospital, Ann Arbor, Michigan, 48109, United States|Summit Medical Group PA, Florham Park, New Jersey, 07932, United States|Perlmutter Cancer Center at NYU Langone Hospital - Long Island, Mineola, New York, 11501, United States|New York University Langone Health, New York, New York, 10016, United States|Columbia University Irving Medical Center, New York, New York, 10032, United States|Memorial Sloan Kettering Cancer Center, New York, New York, 10065, United States|Gabrail Cancer Center Research, Canton, Ohio, 44701, United States|Providence Cancer Center, Portland, Oregon, 97213, United States|Providence Oncology & Hematology Care Clinic-Westside, Portland, Oregon, 97225, United States|UPMC Hillman Cancer Center, Pittsburg, Pennsylvania, 15232, United States|Medical University of South Carolina, Charleston, South Carolina, 29425, United States|Virginia Cancer Specialists, Fairfax, Virginia, 22031, United States|Hong Kong University - Queen Mary Hospital, Hong Kong, Hong Kong|Azienda Ospedaliero Universitaria Careggi, Careggi, Italy|Azienda Ospedaliero Universitaria Ospedali Riuniti Umberto I, Marche, Italy|Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy|IRCCS-Istituto Europeo di Oncologia, Milano, Italy|Azienda Ospedaliero Universitaria Modena, Modena, Italy|San Gerardo Hospital, Monza, Italy|Ospedale Santa Maria delle Croci, Ravenna, Italy|National Cancer Center Hospital East, Chiba, Japan|Niigata Cancer Center, Niigata, Japan|Osaka City General Hospital, Osaka, Japan|Osaka International Cancer Institute, Osaka, Japan|Shizuoka Cancer Center, Shizuoka, Japan|National Cancer Center Hospital, Tokyo, Japan|The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan|National Cancer Center, Goyang-si, Korea, Republic of|Seoul National University Bundang Hospital (SNUBH), Gyeonggi-do, Korea, Republic of|Gachon University Gil Medical Center, Incheon, Korea, Republic of|Inha University Hospital, Incheon, Korea, Republic of|Samsung Medical Center, Seoul, Korea, Republic of|Asan Medical Center (AMC), Soeul, Korea, Republic of|Korea University Guro Hospital, Soeul, Korea, Republic of|Ajou University Hospital, Suwon-si, Korea, Republic of|The Catholic University Of Korea St. Vincent's Hospital, Suwon-si, Korea, Republic of|The Netherlands Cancer Institute (NKI), Amsterdam, 1066 CX, Netherlands|Leiden University Medical Center, Leiden, 2333 ZA, Netherlands|Singapore Clinical Research Institute, Singapore, 138669, Singapore|National Cancer Centre Singapore, Singapore, 169610, Singapore|University Hospital A Coruna, A Coru?a, Spain|Hospital Clinic i Provincial de Barcelona, Barcelona, Spain|Hospital Parc Tauli, Barcelona, Spain|Hospital Universitario Vall d'Hebron, Barcelona, Spain|Institut Catala d'Oncologia l'Hospitalet, Barcelona, Spain|START Barcelona, Barcelona, Spain|Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas, Spain|Hospital General Universitario Gregorio Maranon (HGUGM), Madrid, Spain|Hospital Universitario Puerta de Hierro de Majadahonda, Madrid, Spain|University Hospital Quironsalud Madrid, Madrid, Spain|Hospital Regional Universitario de Malaga, Málaga, Spain|Clinica Universidad de Navarra, Pamplona, Spain|Universitat de Valencia - Hospital Universitari i Politecnic La Fe de Valencia (Hospital La Fe Bulevar Sur), Valencia, Spain|Chang Gung Medical Foundation Chiayi Chang Gung Memorial Hospital, Chiayi City, Taiwan|Chung Shan Medical University Hospital, Taichung, Taiwan|Taichung Veterans General Hospital, Taichung, Taiwan|National Taiwan University Hospital, Taipei, 10002, Taiwan|Taipei Medical University Hospital, Taipei, Taiwan Less << |
Tags: Zipalertinib | TAS6417 | CLN-081 | TAS 6417 | TAS-6417 | CLN081 | CLN 081 | CLN-081 | EGFR | Apoptosis | Epidermal growth factor receptor | ErbB-1 | HER1 | NSCLC | lung | cancer | Akt | PC-9 | H1975 | BID007 | BID019 | BEAS-2B | 1661854-97-2
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P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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