Products Cited in Publications Worldwide Aurantio‐Obtusin Suppresses Airway Inflammation and Serum ICAM‐1 Expression in Guinea Pig Allergic Asthma Model

Aurantio‐Obtusin Suppresses Airway Inflammation and Serum ICAM‐1 Expression in Guinea Pig Allergic Asthma Model

Nyarko, Mavis Sersah; Danquah, Cynthia Amaning; Antwi, Aaron Opoku; Emikpe, Benjamin Obukowho; Osafo, Newman

DOI: PMID:

Abstract

Introduction: Aurantio-obtusin is a trihydroxyanthraquinone found in the seeds of Cassia tora and Cassia obtusifolia. Its neuroprotective, anti-inflammatory, anti-allergic, and antioxidant potential has been documented in multiple studies. While previous reports mention its potential as an antiasthma agent, its effects on allergen‐induced airway inflammation have not been explored. Method: Our study reports on the mechanisms by which aurantio-obtusin exerts its effects on underlying inflammation in experimentally‐induced allergic asthma. The effect of aurantio-obtusin pretreatment on molecular and histological changes in guinea pig lungs when challenged with aerosolized ovalbumin was assessed. Results: Our results showed that aurantio-obtusin significantly reduced ovalbumin (OVA)‐induced increase in serum OVA-specific immunoglobulin E (OVA‐sIgE) and intercellular adhesion molecule (ICAM)‐1. Aurantio‐obtusin further suppressed inflammatory cytokine expression (IL‐8, TNF‐α, IL‐6 and thymic stromal lymphopoietin) as well as malondialdehyde, a product of oxidative stress in bronchial lavage. The histopathological assessment showed a reduced transit of inflammatory cells and reduced deposition of collagen in the lungs of aurantio-obtusin-treated guinea pigs. Conclusion: Overall, the data suggests that aurantio-obtusin mitigated ovalbumin‐induced airway inflammation by impeding the production of OVAsIgE and suppressing levels of key pro‐inflammatory cytokines. Our findings suggest that aurantio-obtusin has potential benefits in the management of allergic airway inflammation in type 2 asthma.

Keywords

airway inflammation ; Allergy ; asthma ; aurantio-obtusin ; intercellular adhesion molecule-1 ; plant-derived compound

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Aurantio-obtusin

A22104267979-25-398%

Aurantio-obtusin

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