Products Cited in Publications Worldwide In vivo antibody-selective conjugation technology for long-acting drugs

In vivo antibody-selective conjugation technology for long-acting drugs

Kitahara, Katsushi; Rondon, Aurélie; Miller, Edward; Mak, Howard H; Loas, Andrei; Pentelute, Bradley L

DOI:

Abstract

Peptide-based therapeutics are currently in great demand but often suffer from rapid clearance and accumulation in off-target tissues, which continue to present barriers in their clinical translation. We report the development of an electrophilic peptide for the attachment of therapeutics to native immunoglobulin G (IgG) antibodies in vivo. This reactive scaffold enables the biorthogonal, selective covalent linkage of drugs of choice to circulating IgGs directly in live animals. Native IgG-selective conjugation with glucagon-like peptide-1 (GLP-1) results in sustained body weight loss and prolonged blood glucose management after one dose. This versatile technology has the potential to advance the next generation of long-acting peptide-based medicines.

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