Products Cited in Publications Worldwide Formulation development of tazarotene-loaded PLGA nanoparticles for follicular delivery in the treatment of inflammatory skin diseases

Formulation development of tazarotene-loaded PLGA nanoparticles for follicular delivery in the treatment of inflammatory skin diseases

Sharvari M. Kshirsagar; Nisha Shrestha; Thomas Kipping; Ajay K. Banga

DOI: PMID:

Abstract

is a widely prescribed topical retinoid for acne vulgaris and plaque psoriasis and is associated with skin irritation, dryness, flaking, and photosensitivity. In vitro permeation of was studied across the dermatomed human and full-thickness porcine skin. The conversion of to the active form was studied in various skin models. Tazarotene-loaded nanoparticles were prepared using the nanoprecipitation technique to target skin and hair follicles effectively. The effect of formulation and processing variables on nanoparticle properties, such as particle size and drug loading, was investigated. The optimized nanoparticle batches with particle size <500 µm were characterized further for FT-IR analysis, which indicated no interactions between and . Scanning electron microscopy analysis showed uniform, spherical, and non-agglomerated nanoparticles. In vitro release study using a dialysis membrane indicated a sustained release of 40–70 % for different batches over 36 h, following a diffusion-based release mechanism based on the Higuchi model. In vitro permeation testing (IVPT) in full-thickness porcine skin showed significantly enhanced follicular and skin delivery from nanoparticles compared to solution. The presence of in the skin from nanoparticles indicated the effectiveness of nanoparticle formulations in retaining bioconversion ability and targeting follicular delivery.

Keywords

; ; nanoparticles ; follicular delivery ; acne ; psoriasis ; tape stripping ; skin

Purchased from AmBeed

Tazarotenic acid

A873292118292-41-498%

Tazarotenic acid

700.0/1g

Detail