Petzer, Anél; Petzer, Jacobus P; Cloete, Stephanus J

DOI: PMID:

Abstract

(AChE) is present in the venom of Elapid snakes, except the Mambas. Although the physiological role of in snake venom is uncertain, it may contribute to acute neuromuscular paralysis following envenomation. With the aim of repurposing clinically used drugs for snakebite envenoming, this study investigated the inhibition of from snake species of Southern Africa. Hemachatus haemachatus and Naja nivea venom presented with high activity, which was inhibited by , galantamine and with IC50 values ranging from 0.49 to 3.73 μM.

Keywords

; ; Galantamine ; ; Venom ; Snakebite

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