Products Cited in Publications Worldwide Selective quantitative N-functionalization of unprotected α-amino acids using NHC-Ir(III) catalyst

Selective quantitative N-functionalization of unprotected α-amino acids using NHC-Ir(III) catalyst

Saavedra, Beatriz; Bermejo-Lopez, Aitor; Raeder, Majken; Martin-Matute, Belen

DOI: PMID:

Abstract

Unnatural amino acids are valuable building blocks with numerous applications. Here, we present a quant. technique for accessing mono-N-functionalized amino acids directly from unprotected substrates using alcs. as alkylating agents and an NHC-Ir(III) catalyst. We detail specific steps for catalyst preparation and application, as well as for catalyst recycling. The protocol excludes a few amino acids (L-cysteine, L-lysine, and L-arginine) and secondary alcs. For complete details on the use and execution of this protocol, please refer to Bermejo-Loṕez et al. (2022).1

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Silver bis(trifluoromethanesulfonyl)imide

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Silver bis(trifluoromethanesulfonyl)imide

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