Home Products Cited in Publications Worldwide Protocol to generate two distinct standard-of-care murine glioblastoma models for evaluating novel combination therapies
STAR Protoc.,2024,5(3):103304.
Pineau, Raphael; Le Reste, Pierre Jean; Avril, Tony; Jarry, Ulrich; Chevet, Eric; Pelizzari-Raymundo, Diana
DOI:10.1016/j.xpro.2024.103304 PMID:39269900
In cancer research, murine models play a crucial role as highly valuable preclinical tools. Here, we present a protocol to generate a murine model of glioblastoma through the direct intracranial injection of tumor cells. We describe steps for cell culture, intracranial implantation, and standard-of-care treatments. We then detail procedures for monitoring tumor growth using bioluminescent imaging.