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[ CAS No. 1338934-59-0 ] {[proInfo.proName]}

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Chemical Structure| 1338934-59-0
Chemical Structure| 1338934-59-0
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Gideon Ong ; Rosemund Ragetli ; Katarzyna Mnich , et al. DOI:

Abstract: The Unfolded Response (UPR) is an essential cellular process activated by the accumulation of unfolded proteins within the Endoplasmic Reticulum (ER), a condition referred to as ER stress. Three ER anchored receptors, , and ATF6 act as ER stress sensors monitoring the health of the ER. Upon detection of ER stress, , and ATF6 initiate downstream signaling pathways collectively referred to as the UPR. The overarching aim of the UPR is to restore ER homeostasis by reducing ER stress, however if that is not possible, the UPR transitions from a pro-survival to a pro-death response. While our understanding of the key signaling pathways central to the UPR is well defined, the same is not true of the subtle signaling events that help fine tune the UPR, supporting its ability to adapt to varying amplitudes or durations of ER stress. In this study, we demonstrate cross talk between the and branches of the UPR, wherein via XBP1s signaling helps to sustain expression during prolonged ER stress. Our findings suggest cross talk between UPR branches aids adaptiveness thereby helping to support the plasticity of UPR signaling responses.

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Pineau, Raphael ; Le Reste, Pierre Jean ; Avril, Tony , et al. DOI: PubMed ID:

Abstract: In cancer research, murine models play a crucial role as highly valuable preclinical tools. Here, we present a protocol to generate a murine model of glioblastoma through the direct intracranial injection of tumor cells. We describe steps for , intracranial implantation, and standard-of-care treatments. We then detail procedures for monitoring tumor growth using bioluminescent imaging.

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Product Details of [ 1338934-59-0 ]

CAS No. :1338934-59-0 MDL No. :MFCD31540824
Formula : C18H19NO7 Boiling Point : -
Linear Structure Formula :- InChI Key :IFDGMRMUJYGWQQ-UHFFFAOYSA-N
M.W : 361.35 Pubchem ID :89542346
Synonyms :
IRE-1α inhibitor 1
Chemical Name :7-Hydroxy-6-methoxy-4-methyl-3-(2-morpholino-2-oxoethyl)-2-oxo-2H-chromene-8-carbaldehyde

Safety of [ 1338934-59-0 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P280-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:
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