Products Cited in Publications Worldwide Development of an Injectable, ECM-Derivative Embolic for the Treatment of Cerebral Saccular Aneurysms

Development of an Injectable, ECM-Derivative Embolic for the Treatment of Cerebral Saccular Aneurysms

Seungil Kim; Kamil W. Nowicki; Keishi Kohyama; Aditya Mittal; Sangho Ye; Kai Wang; Taro Fujii; Shivbaskar Rajesh; Catherine Cao; Rohit Mantena; Marianna Barbuto; Youngmee Jung; Bradley A. Gross; Robert M. Friedlander; William R. Wagner

DOI: PMID:

Abstract

Cerebral aneurysms are a source of neurological morbidity and mortality, most often as a result of rupture. The most common approach for treating aneurysms involves endovascular embolization using nonbiodegradable medical devices, such as coils. However, the need for retreatment due to the recanalization of coil-treated aneurysms highlights the importance of exploring alternative solutions. In this study, we propose an injectable extracellular matrix derived embolic formed in situ by of gelatin-thiol (Gel-SH) and hyaluronic acid vinyl (HA-VS) that may be delivered with a therapeutic agent (here, RADA-SP) to fill and remodel aneurysmal tissue without leaving behind permanent foreign bodies. The injectable embolic material demonstrated rapid gelation under physiological conditions, forming a highly porous structure and allowing for cellular infiltration. The injectable embolic exhibited thrombogenic behavior in vitro that was comparable to that of alginate injectables. Furthermore, in vivo studies in a murine carotid aneurysm model demonstrated the successful embolization of a saccular aneurysm and extensive cellular infiltration both with and without RADA-SP at 3 weeks, with some evidence of increased vascular or fibrosis markers with RADA-SP incorporation. The results indicate that the developed embolic has inherent potential for acutely filling cerebrovascular aneurysms and encouraging the cellular infiltration that would be necessary for stable, chronic remodeling.

Purchased from AmBeed

A70004015441-06-295%

Dimethyl 3,3-Dithiodipropionate

67.0/1kg

Detail