Products Cited in Publications Worldwide Economical and Readily Accessible Preparation of o, o-Disubstituted Arylboronates through Palladium-Catalyzed Borylation of Haloarenes

Economical and Readily Accessible Preparation of o, o-Disubstituted Arylboronates through Palladium-Catalyzed Borylation of Haloarenes

Kuwano, Ryoichi; Lee, Eunhyung; Won, Sungyong

DOI: PMID:

Abstract

Miyaura borylation, that is, palladium-catalyzed cross-coupling between bromoarenes and diboron, offers a versatile method for preparing arylboronates; however, a costly and inaccessible catalyst has been required for synthesizing highly congested arylboronates with the method. Here the Pd(OAc)2–tri(4-methoxyphenyl)phosphine catalyst was found to work as an efficient catalyst for the sterically demanding borylation. A broad range of o,o-disubstituted bromoarenes were converted into the corresponding arylboronates in high yields by using the palladium catalyst with Cs2CO3 in EtOAc at 80℃.

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