Products Cited in Publications Worldwide Albumin/Magnetite/Hematoporphyrin Composite Nanoparticles as Drug Carriers for the Photodynamic Therapy of Oral Squamous Cell Carcinoma

Albumin/Magnetite/Hematoporphyrin Composite Nanoparticles as Drug Carriers for the Photodynamic Therapy of Oral Squamous Cell Carcinoma

Liu, Andong; Xia, Haining; Yang, Hao; Xu, Xinyi; Li, Chengjing; Li, Xiaowen; Chen, Ruiguo; Ma, Kun; Hou, Jun; Sun, Lei

DOI:

Abstract

, a , has substantial potential for photodynamic therapy (PDT) in oral squamous cell carcinoma (OSCC). However, the strong hydrophobic interactions between molecules cause them to easily aggregate, leading to poor solubility in water and suppression of active photoreactive sites. To address these challenges, a biomimetic synthesis strategy was employed to organically integrate ferroferric oxide (Fe3O4) nanoparticles with , resulting in the construction of highly hydrophilic and efficient Fe3O4/Haematoporphyrin@BSA (BMH) nanoparticles. This delivery system effectively improved the solubility, bioavailability, and PDT efficiency of . Compared with free , the BMH nanoparticles exhibited a smaller average hydrated particle size with excellent dispersion in the PBS solution. Additionally, BMH nanoparticles demonstrated efficient cellular uptake by CAL27 tumor cells in a shorter time frame. PDT experiments on CAL27 tumor cells revealed that under the same light exposure, the BMH nanoparticles resulted in a 58% increase in generation, leading to a 57% increase in cell death compared to the group. Notably, the electron spin resonance spectrometer (ESR) results and structural analysis of the protein cages suggested that the organic integration of Fe3O4 nanoparticles with enhanced electron transfer and increased free radical production, thereby improving overall PDT efficiency. This study demonstrated that highly biocompatible BMH protein-cage nanoparticles significantly enhanced the therapeutic potential of for PDT in OSCC.

Keywords

potential ; PDT ; cell ; ; leading ; Fe3O4 ; nanoparticles ; hematoporphyrin ; highly ; efficient ; BMH ; free ; demonstrated ; CAL27 ; tumor ; cells ; increase ; electron ; enhanced

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Triacetonamine HCl

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