Products Cited in Publications Worldwide IRE1 signaling increases PERK expression during chronic ER stress

IRE1 signaling increases PERK expression during chronic ER stress

Gideon Ong; Rosemund Ragetli; Katarzyna Mnich; Bradley W. Doble; Wafa Kammouni; Susan E. Logue

DOI:

Abstract

The Unfolded Response (UPR) is an essential cellular process activated by the accumulation of unfolded proteins within the Endoplasmic Reticulum (ER), a condition referred to as ER stress. Three ER anchored receptors, , and ATF6 act as ER stress sensors monitoring the health of the ER. Upon detection of ER stress, , and ATF6 initiate downstream signaling pathways collectively referred to as the UPR. The overarching aim of the UPR is to restore ER homeostasis by reducing ER stress, however if that is not possible, the UPR transitions from a pro-survival to a pro-death response. While our understanding of the key signaling pathways central to the UPR is well defined, the same is not true of the subtle signaling events that help fine tune the UPR, supporting its ability to adapt to varying amplitudes or durations of ER stress. In this study, we demonstrate cross talk between the and branches of the UPR, wherein via XBP1s signaling helps to sustain expression during prolonged ER stress. Our findings suggest cross talk between UPR branches aids adaptiveness thereby helping to support the plasticity of UPR signaling responses.

Purchased from AmBeed

MKC8866

A10035331338934-59-099%

MKC8866

2347.0/1g

Detail