Products Cited in Publications Worldwide Glucose-responsive microneedle patch for closed-loop dual-hormone delivery in mice and pigs

Glucose-responsive microneedle patch for closed-loop dual-hormone delivery in mice and pigs

Yang, Changwei; Sheng, Tao; Hou, Wenhui; Zhang, Juan; Cheng, Li; Wang, Hao; Liu, Wei; Wang, Shiqi; Yu, Xinmin; Zhang, Yuqi; Yu, Jicheng; Gu, Zhen

DOI: PMID:

Abstract

Insulin and glucagon secreted from the pancreas with dynamic balance play a vital role in regulating blood glucose levels. Although distinct glucose-responsive insulin delivery systems have been developed, the lack of a self-regulated glucagon release module limits their clin. applications due to the potential risk of hypoglycemia. Here, we describe a transdermal polymeric microneedle patch for glucose-responsive closed-loop insulin and glucagon delivery to achieve glycemic regulation with minimized risk of hypoglycemia. The glucose-responsive phenylboronic acid units can bind to glucose to reversibly shift the net charge (from pos. to neg.) of the entire polymeric matrix within microneedles. Therefore, the release ratio of the neg. charged insulin and the pos. charged glucagon analog from the patch can be dynamically tuned upon the fluctuation of blood glucose levels to realize glycemic homeostasis. In both chem. induced type 1 diabetic mouse and minipig models, this glucose-responsive dual-hormone microneedle patch demonstrated tight long-term regulation in blood glucose levels (>24 h in minipigs).

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