Products Cited in Publications Worldwide A method to use X-ray computed tomography for measuring perfusable, high-resolution 3D-printed hydrogel structures

A method to use X-ray computed tomography for measuring perfusable, high-resolution 3D-printed hydrogel structures

Kafka, Orion L; Kolibaba, Thomas J; Wendland, Rion J; Higgins, Callie I; Draper, Grant; Clinton, Nick; Sridhar, Raghuveer Lalitha; Vydiam, Kalyan; Backman, Daniel; Kaur, Aman

DOI:

Abstract

Contrast-enhancing agents are commonplace in medical X-ray Computed Tomography. However, their use in laboratory-scale micro-X-ray Computed Tomography (µXCT) for morphological measurements of tissue-like or tissue-scaffold applications (e.g., 3D-printed artificial organs) is limited. We demonstrate enhanced contrast and enable print quality measurement with µXCT via a colloidal suspension of nano-silica spheres (c-SiO2). Contrast is enhanced by the higher attenuation coefficient of the silica than hydrogel, which provides for 3D image analysis. We tested several c-SiO2 dilutions and found an optimal selection that balances viscosity and contrast. We further demonstrate the technique by measuring a prototype dialyzer-like device.

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