Products Cited in Publications Worldwide Emulsion-Based Gel Loaded with Ibuprofen and Its Derivatives

Emulsion-Based Gel Loaded with Ibuprofen and Its Derivatives

Agboola, Adebukola Abiola; Nowak, Anna; Duchnik, Wiktoria; Kucharski, Lukasz; Story, Anna; Story, Grzegorz; Struk, Lukasz; Antosik, Adrian Krzysztof; Ossowicz-Rupniewska, Paula

DOI: PMID:

Abstract

The aim of this study was to evaluate the effect of vehicle and chem. modifications of the structure of active compounds on the skin permeation and accumulation of ibuprofen (IBU). As a result, semi-solid formulations in the form of an emulsion-based gel loaded with ibuprofen and its derivatives, such as sodium ibuprofenate (IBUNa) and L-phenylalanine Et ester ibuprofenate ([PheOEt][IBU]), were developed. The properties of the obtained formulations were examined, including d., refractive index, viscosity, and particle size distribution. The parameters of release and permeability through the pig skin of the active substances contained in the obtained semi-solid formulations were determined The results indicate that an emulsion-based gel enhanced the skin penetration of IBU and its derivatives compared to two com. preparations in the form of a gel and a cream. The average cumulative mass of IBU after a 24 h permeation test from an emulsion-based gel formulation through human skin was 1.6-4.0 times higher than for the com. products. Ibuprofen derivatives were evaluated as chem. penetration enhancers. After 24 h of penetration, the cumulative mass was 1086.6 ± 245.8 for IBUNa and 948.6 ± 87.5 μg IBU/cm2 for [PheOEt][IBU], resp. This study demonstrates the perspective of the transdermal emulsion-based gel vehicle in conjunction with the modification of the drug as a potentially faster drug delivery system.

Keywords

carbomer ; increasing drug permeability ; nonsteroidal anti-inflammatory drugs ; ibuprofen ; transdermal drug delivery ; structural modification of ibuprofen

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Ibuprofen

A23870215687-27-198%

Ibuprofen

10.0/1mg

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