Products Cited in Publications Worldwide Triterpenic Acid Amides as Potential Inhibitors of the SARS-CoV-2 Main Protease

Triterpenic Acid Amides as Potential Inhibitors of the SARS-CoV-2 Main Protease

Baev, Dmitry S.; Blokhin, Mikhail E.; Chirkova, Varvara Yu.; Belenkaya, Svetlana V.; Luzina, Olga A.; Yarovaya, Olga I.; Salakhutdinov, Nariman F.; Shcherbakov, Dmitry N.

DOI: PMID:

Abstract

Although the incidence and mortality of SARS-CoV-2 infection has been declining during the pandemic, the problem related to designing novel antiviral drugs that could effectively resist viruses in the future remains relevant. As part of our continued search for chem. compounds that are capable of exerting an antiviral effect against the SARS-CoV-2 virus, we studied the ability of triterpenic acid amides to inhibit the SARS-CoV-2 main protease. Mol. modeling suggested that the compounds are able to bind to the active site of the main protease via non-covalent interactions. The FRET-based enzyme assay was used to reveal that compounds 1e and 1b can inhibit the SARS-CoV-2 main protease at micromolar concentrations

Keywords

triterpene amide ; SARS-CoV-2 ; main protease ; molecular modeling ; FRET ; antiviral

Purchased from AmBeed

ML188

A12574671417700-13-099%

ML188

79.0/5mg

Detail