Products Cited in Publications Worldwide Synthesis of RNA Nucleotides under Probable Prebiotic Conditions

Synthesis of RNA Nucleotides under Probable Prebiotic Conditions

Stimson, Ryan

Abstract

RNA being composed of multiple covalently linked nucleotides is thought to have been a precursor to life circa 4.3-3.8 billion years ago. Non-enzymatically formed adenosine monophosphate (AMP), more specifically, is a vitally important subtopic of the self-assembly of the first RNA sequence. The goal of this study was to synthesize AMP non-enzymatically under benign conditions that are likely to have existed on early Earth. In this experiment, 3’,5’-cAMP was successfully formed using wet-dry cycles at 80°C paired with the minerals zeolite beta, hydroxyapatite, and aerosil 300 in the presence of adenosine, urea, and pyrophosphate. A nuclear magnetic resonance spectrometer was used to characterize the products of each experiment to determine if any adenosine nucleotides were formed. Decreasing the pH and having a higher number of wet-dry cycles results in a higher amount of cAMP formation.

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A16019756-65-595%

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