Padilla, Marshall Scott

Abstract

Most potent therapeutics fail to reach clinical trials and FDA-approval due to their inability to reach their target in a safe and controlled manner. To overcome these barriers, nanotechnology can be employed to create vehicles that aid in the delivery of drugs. One promising class of drug delivery vehicles are nanoemulsions, which are nanometer-sized particles that contain a hydrophobic droplet that houses and protects the therapeutics. Nanoemulsions have seen success in the delivery of drugs as several nanoemulsion formulations have received FDA-approved. However, despite their success, one of their limiting factors is their lack of diverse hydrophobic components. Typically, the hydrophobic droplet is a lipid, and as a result, only drugs that are lipophilic can be dissolved. This means that hydrophilic small molecule and biological therapeutics cannot be formulated, significantly reducing the potential of this drug delivery vehicle.

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