Chemistry Heterocyclic Building Blocks Pyrimidines

Pyrimidines

Pyrimidine is an organic compound with an aromatic and heterocyclic structure, closely resembling pyridine. It belongs to the class of diazines, which are heterocyclic compounds containing two nitrogen atoms in the six-membered ring. In pyrimidine, the nitrogen atoms are positioned at positions 1 and 3 within the ring.The principal synthesis for the production of pyrimidines usually involves the cyclization of β-dicarbonyl compounds with N-C-N compounds. Typical reactions include the synthesis of 2-substituted pyrimidines by reacting the former with amidines, the synthesis of 2-pyrimidinones by reacting with urea, and the synthesis of 2-aminopyrimidines by reacting with guanidines.Pyrimidines are typically utilized by cells as a source of energy, and they are crucial for synthesizing DNA and RNA, proteins, starch, regulating enzymes, signaling between cells, and other important biological functions.Pyrimidines, also known as 1,3-diazines, consist of a six-membered heteroaromatic ring that contains two nitrogen atoms located at positions 1 and 3. This chemical compound is one of three isomeric forms of diazine, the other two being pyridazine and pyrazine.Pyrimidines, similar to pyridines, exhibit a greater decrease in π-electron density. As a result, electrophilic aromatic substitution is hindered, while nucleophilic aromatic substitution is promoted.
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(R)-7-(Tetrahydrofuran-2-Yl)-7H-Pyrrolo[2,3-D]Pyrimidine (R)-N-(Piperidin-3-Yl)-7H-Pyrrolo[2,3-D]Pyrimidin-4-Amine 1,4,5,6-Tetrahydropyrimidine 1-(3-Fluorotetrahydrofuran-2-Yl)Pyrimidin-2(1H)-One 1-(5-(Hydroxymethyl)Tetrahydrofuran-2-Yl)Pyrimidine-2,4(1H,3H)-Dione 1-(Pyrimidin-2-Yl)Ethan-1-One 1-(Pyrimidin-4-Yl)Ethan-1-One 1-(Tetrahydrofuran-2-Yl)Pyrimidin-2(1H)-One 1H-Pyrazolo[3,4-D]Pyrimidin-4-Amine 1H-Pyrazolo[4,3-D]Pyrimidine 2,4,5-Trichloropyrimidine 2,4,6-Trichloropyrimidine 2,4,6-Triphenylpyrimidine 2,4-Dichloro-6-Methylpyrimidine 2,4-Dichloropyrimidin-5-Amine 2,4-Dimethoxypyrimidine 2,4-Dimethylpyrimidine 2-(1H-Pyrazol-1-Yl)Pyrimidine 2-(Chloromethyl)Pyrimidine 2-(Methylsulfonyl)Pyrimidine 2-(Methylthio)Pyrimidin-4-Amine 2-(Methylthio)Pyrimidine 2-(Piperazin-1-Yl)Pyrimidine 2-(Piperidin-1-Yl)Pyrimidine 2-(Propylthio)Pyrimidine 2-(Pyridin-2-Yl)Pyrimidine 2-(Pyrrolidin-1-Yl)Pyrimidine 2-(Trifluoromethyl)Pyrimidine 2-Aminopyrimidin-4(3H)-One 2-Bromopyrimidine 2-Chloro-4-(Trifluoromethyl)Pyrimidine 2-Chloro-4-Methoxypyrimidine 2-Chloro-4-Methylpyrimidine 2-Chloro-4-Phenylpyrimidine 2-Chloro-5-Fluoropyrimidine 2-Chloro-5-Methylpyrimidine 2-Chloro-5-Nitropyrimidine 2-Chloro-7H-Pyrrolo[2,3-D]Pyrimidine 2-Chloropyrimidin-4-Amine 2-Cyclopropylpyrimidine 2-Ethoxypyrimidine 2-Ethylpyrimidine 2-Fluoropyrimidine 2-Hydrazineylpyrimidine 2-Iodopyrimidine 2-Methoxypyrimidin-4-Amine 2-Methoxypyrimidine 2-Methylpyrimidin-4-Amine 2-Methylpyrimidin-4-Ol 2-Phenoxypyrimidine 2-Phenylpyrimidin-5-Amine 3-Methylpyrimidin-4(3H)-One 4,5-Dichloropyrimidine 4,6-Dichloro-2-(Methylthio)Pyrimidine 4,6-Dichloro-2-Methylpyrimidine 4,6-Dichloropyrimidin-2-Amine 4,6-Dichloropyrimidine 4,6-Diphenylpyrimidine 4-(Dimethoxymethyl)Pyrimidine 4-(Piperazin-1-Yl)Pyrimidine 4-(Piperidin-1-Yl)Pyrimidine 4-(Pyridin-3-Yl)Pyrimidine 4-(Pyrimidin-2-Yl)Morpholine 4-(Pyrimidin-4-Yl)Morpholine 4-(Trifluoromethyl)Pyrimidin-2-Amine 4-(Trifluoromethyl)Pyrimidine 4-Amino-1-(Tetrahydrofuran-2-Yl)Pyrimidin-2(1H)-One 4-Bromopyrimidine 4-Chloro-2-(Methylthio)Pyrimidine 4-Chloro-2-Methoxypyrimidine 4-Chloro-2-Phenylpyrimidine 4-Chloro-5-Fluoro-2-Methylpyrimidine 4-Chloro-5-Iodopyrimidine 4-Chloro-5-Methoxypyrimidine 4-Chloro-5-Methylpyrimidine 4-Chloro-6-Methoxypyrimidine 4-Chloropyrimidin-2-Amine 4-Chloropyrimidin-5-Amine 4-Chloropyrimidine-5-Carbonitrile 4-Ethoxypyrimidine 4-Fluoropyrimidine 4-Iodopyrimidine 4-Methoxy-2-Methylpyrimidine 4-Methoxypyrimidin-2-Amine 4-Methoxypyrimidine 4-Methyl-2-(Methylthio)Pyrimidine 4-Methylpyrimidin-2-Amine 4-Methylpyrimidine 4-Phenoxypyrimidine 4-Phenylpyrimidin-2-Amine 5,6,7,8-Tetrahydropyrido[3,4-D]Pyrimidine 5,6,7,8-Tetrahydropyrido[4,3-D]Pyrimidine 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidine 5-(Benzyloxy)Pyrimidine 5-Benzylpyrimidine 5-Bromo-1-(Tetrahydrofuran-2-Yl)Pyrimidine-2,4(1H,3H)-Dione 5-Bromo-2-(Methylthio)Pyrimidine 5-Bromo-2-Chloropyrimidine 5-Bromo-2-Methylpyrimidine 5-Bromo-4-Chloropyrimidine 5-Bromo-7H-Pyrrolo[2,3-D]Pyrimidine 5-Bromopyrimidin-4(3H)-One 5-Chloropyrimidin-4(3H)-One 5-Chloropyrimidine 5-Chloropyrimidine-2,4(1H,3H)-Dione 5-Ethylpyrimidine 5-Fluoro-1-(Tetrahydrofuran-2-Yl)Pyrimidin-2(1H)-One 5-Fluoro-1-(Tetrahydrofuran-2-Yl)Pyrimidine-2,4(1H,3H)-Dione 5-Fluoropyrimidin-4(3H)-One 5-Fluoropyrimidine 5-Fluoropyrimidine-2,4(1H,3H)-Dione 5-Iodo-7H-Pyrrolo[2,3-D]Pyrimidine 5-Iodopyrimidine 5-Methylpyrimidine 5-Phenylpyrimidine 5H-Pyrrolo[3,2-D]Pyrimidine 6,7-Dihydro-5H-Cyclopenta[D]Pyrimidine 6,7-Dihydro-5H-Pyrrolo[3,4-D]Pyrimidine 6-Chloro-1H-Pyrazolo[3,4-D]Pyrimidine 6-Chloropyrimidin-4-Amine 7-(Phenylsulfonyl)-7H-Pyrrolo[2,3-D]Pyrimidine 7H-Pyrrolo[2,3-D]Pyrimidin-2-Amine 7H-Pyrrolo[2,3-D]Pyrimidin-4-Amine [1,2,4]Triazolo[1,5-A]Pyrimidine Ethyl 4-Chloropyrimidine-5-Carboxylate Ethyl Pyrazolo[1,5-A]Pyrimidine-3-Carboxylate Ethyl Pyrimidine-4-Carboxylate Ethyl Pyrimidine-5-Carboxylate Imidazo[1,2-C]Pyrimidine Methyl Pyrimidine-2-Carboxylate Methyl Pyrimidine-4-Carboxylate Methyl Pyrimidine-5-Carboxylate N,N-Dimethylpyrimidin-2-Amine N-(9-((2R,5S)-5-((Trityloxy)Methyl)Tetrahydrofuran-2-Yl)-9H-Purin-6-Yl)Benzamide N-Benzyl-9H-Purin-6-Amine N-Cyclopropylpyrimidin-2-Amine N-Methyl-N-(4-Phenylpyrimidin-2-Yl)Methanesulfonamide N-Methylpyrimidin-2-Amine N-Methylpyrimidin-4-Amine N-Phenyl-4-(Pyridin-3-Yl)Pyrimidin-2-Amine N-Phenylpyrimidin-2-Amine N-Phenylpyrimidin-4-Amine N2,N4-Diphenylpyrimidine-2,4-Diamine Pyrido[2,3-D]Pyrimidine Pyrido[3,2-D]Pyrimidine Pyrido[3,4-D]Pyrimidine Pyrimidin-2-Ol Pyrimidin-2-Ylmethanamine Pyrimidin-2-Ylmethanol Pyrimidin-4-Amine Pyrimidin-4-Ol Pyrimidin-5-Amine Pyrimidin-5-Ol Pyrimidin-5-Ylboronic Acid Pyrimidine-2,4-Diamine Pyrimidine-2-Carbonitrile Pyrimidine-2-Carboxylic Acid Pyrimidine-2-Thiol Pyrimidine-4,6(1H,5H)-Dione Pyrimidine-4-Carbonitrile Pyrimidine-4-Carboxylic Acid Pyrimidine-5-Carbaldehyde Pyrimidine-5-Carbonitrile Pyrimidine-5-Carboxylic Acid Tetrahydropyrimidin-2(1H)-One Thiazolo[5,4-D]Pyrimidine Thieno[2,3-D]Pyrimidine Thieno[3,2-D]Pyrimidine

By Key Group+−

Bipyrimidine Dibromopyrimidine Methoxypyrimidine Pyrimidinone Tetraoxatetradecan Trichloropyrimidine

By Parent Nucleus+−

Azetidines Indoles Morpholines Piperazines Piperidines Pyrrolidines Thiophenols

By Functional Group+−

Alcohols Aldehydes Alkenyls Alkynyls Amides Amidines Amines Aryls Bromides Carboxylic Acids Chlorides Difluoromethyls Esters Ethers Fluorinated Building Blocks Hydrazines Iodides Ketones Nitriles Nitroes Sulfamides Sulfides Sulfones Trifluoromethyls

By Chemical Elements+−

    Bx
    Cx
    Nx
    Ox
    Fx
    Six
    Px
    Sx
    Clx
    Brx
    Ix

    Formula Weight+−

    cLogP+−

    H-Acceptors+−

    H-Donors+−

    Polar Surface Area+−

    Druglikeness+−

    NNCH/NNH+−

    sp3-Atoms+−

    Non-Aromatic Rings+−

    Aromatic Rings+−

    Rotatable Bonds+−

    By Configuration+−

    2-(Dimethylamino)pyrimidine-5-carboxylic acid

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    A203653180283-66-398%

    2-(Dimethylamino)pyrimidine-5-carboxylic acid

    $28.00/100mg

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    6-Chloro-N-cyclopropylpyrimidin-4-amine

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    A945623941294-43-598%

    6-Chloro-N-cyclopropylpyrimidin-4-amine

    $48.00/250mg

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    2-(Hydroxymethyl)-5-methoxypyrimidine

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    A4491661459748-95-897%

    2-(Hydroxymethyl)-5-methoxypyrimidine

    $61.00/100mg

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    Methyl 2-(2-Pyrimidyl)acetate

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    A30078060561-50-498%

    Methyl 2-(2-Pyrimidyl)acetate

    $14.00/250mg

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    5-Chloro-2-(methylsulfonyl)pyrimidine

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    A34968238275-47-796%

    5-Chloro-2-(methylsulfonyl)pyrimidine

    $50.00/250mg

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    Ethyl 6-chloro-2-methylpyrimidine-4-carboxylate

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    A389200744253-37-098%

    Ethyl 6-chloro-2-methylpyrimidine-4-carboxylate

    $18.00/100mg

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    5-Phenyluracil

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    A73991215761-83-898%

    5-Phenyluracil

    $71.00/100mg

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    2-(4,6-Dichloro-5-pyrimidyl)ethanol

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    A462517853680-74-795+%

    2-(4,6-Dichloro-5-pyrimidyl)ethanol

    $968.00/10g

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    Ethyl 6-amino-2-thioxo-1,2-dihydropyrimidine-5-carboxylate

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    A229979774-07-298%

    Ethyl 6-amino-2-thioxo-1,2-dihydropyrimidine-5-carboxylate

    $15.00/1g

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    5-Bromo-6-methylpyrimidin-2(1H)-one

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    A24370869849-34-997%

    5-Bromo-6-methylpyrimidin-2(1H)-one

    $129.00/50mg

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    2,4-Dichloro-6-fluoropyrimidine

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    A6779323833-57-695%

    2,4-Dichloro-6-fluoropyrimidine

    $158.00/50mg

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    4,6-Dichloro-2,5-diphenylpyrimidine

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    A74315029133-99-198%

    4,6-Dichloro-2,5-diphenylpyrimidine

    $26.00/250mg

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    2,4-Bis(benzyloxy)pyrimidine

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    A5467587306-79-895%

    2,4-Bis(benzyloxy)pyrimidine

    $55.00/1g

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    Tetrahydropyrimidine-2(1H)-thione

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    A2441302055-46-195%

    Tetrahydropyrimidine-2(1H)-thione

    $10.00/1g

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    2-(N-Anilino)pyrimidine

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    A36742157356-49-798%

    2-(N-Anilino)pyrimidine

    $40.00/100mg

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    Methyl 4-chloropyrimidine-5-carboxylate

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    A6453361246471-45-398%

    Methyl 4-chloropyrimidine-5-carboxylate

    $80.00/250mg

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    5-Bromo-N-(furan-2-ylmethyl)pyrimidin-2-amine

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    A160591886366-01-498%

    5-Bromo-N-(furan-2-ylmethyl)pyrimidin-2-amine

    $40.00/1g

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    2,5-Dibromo-4-methoxypyrimidine

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    A38341589284-12-898%

    2,5-Dibromo-4-methoxypyrimidine

    $350.00/100mg

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    2-Chloro-4-(3-methoxyphenyl)pyrimidine

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    A670951499195-50-595%

    2-Chloro-4-(3-methoxyphenyl)pyrimidine

    $33.00/250mg

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    5-Bromo-1-methylpyrimidine-2,4(1H,3H)-dione

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    A5481996327-97-598%

    5-Bromo-1-methylpyrimidine-2,4(1H,3H)-dione

    $68.00/100mg

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