Benzoxaboroles

Benzoxaboroles are cyclic hemi-esters of boronic acids that exhibit unique drug-like properties, including low toxicity, high hydrolytic stability, and strong diol-binding affinity. These characteristics arise from their low pKa (~7.3), which results in greater anionic character at physiological pH, enhancing water solubility and pharmacokinetics. The presence of a free hydroxyl group and a strongly Lewis acidic boron center contributes to their remarkable chemical and biological properties. Compared to phenylboronic acids, benzoxaboroles display stronger Lewis acidity due to ring strain in their five-membered oxaborole ring, which is relieved upon nucleophilic attack through the formation of a stable tetrahedral anionic species. These properties have enabled the development of FDA-approved drugs such as Tavaborole and Crisaborole, with several other candidates currently in clinical development.

Benzoxaboroles

5-Amino-1,3-dihydro-2,1-benzoxaborol-1-ol
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A809629947165-26-695%

5-Amino-1,3-dihydro-2,1-benzoxaborol-1-ol

$84.00/250mg Detail

1-Hydroxy-2,1-benzoxaborolane
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A6163165735-41-198%

1-Hydroxy-2,1-benzoxaborolane

$187.00/100g Detail

6-Aminobenzo[c][1,2]oxaborol-1(3H)-ol
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A740929117098-94-998%

6-Aminobenzo[c][1,2]oxaborol-1(3H)-ol

$111.00/1g Detail

6-Aminobenzo[c][1,2]oxaborol-1(3H)-ol hydrochloride
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A158832117098-93-897%

6-Aminobenzo[c][1,2]oxaborol-1(3H)-ol hydrochloride

$31.00/100mg Detail

4-Aminobenzo[c][1,2]oxaborol-1(3H)-ol
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A7135151285533-08-597%

4-Aminobenzo[c][1,2]oxaborol-1(3H)-ol

$803.00/1g Detail

tert-Butyl (1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)carbamate
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A535761850568-79-598%

tert-Butyl (1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)carbamate

$77.00/100mg Detail

Benzo[c][1,2]oxaborole-1,6(3H)-diol
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A1873011196473-37-695%

Benzo[c][1,2]oxaborole-1,6(3H)-diol

$155.00/250mg Detail

Benzo[c][1,2]oxaborole-1,5(3H)-diol
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A5916951187190-70-097%

Benzo[c][1,2]oxaborole-1,5(3H)-diol

$30.00/100mg Detail

7-Fluoro-1,3-dihydro-2,1-benzoxaborol-1-ol
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A1083758174671-93-395%

7-Fluoro-1,3-dihydro-2,1-benzoxaborol-1-ol

$40.00/100mg Detail

6-Fluorobenzo[c][1,2]oxaborol-1(3H)-ol
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A647056174671-89-795%

6-Fluorobenzo[c][1,2]oxaborol-1(3H)-ol

$22.00/100mg Detail

Tavaborole
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A200444174671-46-698%

Tavaborole

$27.00/1g Detail

4-Fluorobenzo[c][1,2]oxaborol-1(3H)-ol
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A1004741174671-88-697%

4-Fluorobenzo[c][1,2]oxaborol-1(3H)-ol

$55.00/5g Detail

6-Methoxybenzo[c][1,2]oxaborol-1(3H)-ol
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A243447947163-26-095+%

6-Methoxybenzo[c][1,2]oxaborol-1(3H)-ol

$483.00/1g Detail

5-Methoxy-1,3-dihydro-2,1-benzoxaborol-1-ol
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A860238174671-92-295%

5-Methoxy-1,3-dihydro-2,1-benzoxaborol-1-ol

$152.00/250mg Detail

5-Methylbenzo[c][1,2]oxaborol-1(3H)-ol
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A860237905710-76-195%

5-Methylbenzo[c][1,2]oxaborol-1(3H)-ol

$427.00/1g Detail

5-(Trifluoromethyl)benzo[c][1,2]oxaborol-1(3H)-ol
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A1522644174671-50-298+%

5-(Trifluoromethyl)benzo[c][1,2]oxaborol-1(3H)-ol

$1609.00/5g Detail

1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborole-7-carboxylic acid
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A9887531268335-28-995%

1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborole-7-carboxylic acid

$1234.00/1g Detail

1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborole-6-carboxylic acid
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A8852861221343-14-197%

1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborole-6-carboxylic acid

$22.00/100mg Detail

1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborole-5-carboxylic acid
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A9906471801711-87-498%

1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborole-5-carboxylic acid

$37.00/100mg Detail

1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborole-4-carboxylic acid
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A17215882346531-04-095%

1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborole-4-carboxylic acid

$259.00/100mg Detail

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