Benzoxaboroles

Benzoxaboroles are cyclic hemi-esters of boronic acids that exhibit unique drug-like properties, including low toxicity, high hydrolytic stability, and strong diol-binding affinity. These characteristics arise from their low pKa (~7.3), which results in greater anionic character at physiological pH, enhancing water solubility and pharmacokinetics. The presence of a free hydroxyl group and a strongly Lewis acidic boron center contributes to their remarkable chemical and biological properties. Compared to phenylboronic acids, benzoxaboroles display stronger Lewis acidity due to ring strain in their five-membered oxaborole ring, which is relieved upon nucleophilic attack through the formation of a stable tetrahedral anionic species. These properties have enabled the development of FDA-approved drugs such as Tavaborole and Crisaborole, with several other candidates currently in clinical development.

Benzoxaboroles

1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborole-5-carbonitrile
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A1064289905710-80-795%

1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborole-5-carbonitrile

$447.00/250mg Detail

6-Nitrobenzo[c][1,2]oxaborol-1(3H)-ol
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A696259118803-40-098%

6-Nitrobenzo[c][1,2]oxaborol-1(3H)-ol

$95.00/1g Detail

5-Nitrobenzo[c][1,2]oxaborol-1(3H)-ol
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A1207481875816-94-798%

5-Nitrobenzo[c][1,2]oxaborol-1(3H)-ol

$81.00/250mg Detail

4-Nitrobenzo[c][1,2]oxaborol-1(3H)-ol
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A1147651285533-35-897%

4-Nitrobenzo[c][1,2]oxaborol-1(3H)-ol

$1830.00/5g Detail

6-(Hydroxymethyl)benzo[c][1,2]oxaborol-1(3H)-ol
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A1151116947162-87-098%

6-(Hydroxymethyl)benzo[c][1,2]oxaborol-1(3H)-ol

$503.00/250mg Detail

7-(Bromomethyl)benzo[c][1,2]oxaborol-1(3H)-ol
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A5115331268335-52-997%

7-(Bromomethyl)benzo[c][1,2]oxaborol-1(3H)-ol

$475.00/250mg Detail

2-(1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-7-yl)acetic acid
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A8404631268335-32-597%

2-(1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-7-yl)acetic acid

$599.00/250mg Detail

AN-2898
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A662061906673-33-499%

AN-2898

$57.00/100mg Detail

6-Amino-5-fluorobenzo[c][1,2]oxaborol-1(3H)-ol
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A1207477943311-50-098%

6-Amino-5-fluorobenzo[c][1,2]oxaborol-1(3H)-ol

$285.00/250mg Detail

4-Amino-6-fluorobenzo[c][1,2]oxaborol-1(3H)-ol
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A1721655947165-29-995%

4-Amino-6-fluorobenzo[c][1,2]oxaborol-1(3H)-ol

$164.00/50mg Detail

5-Fluoro-6-nitrobenzo[c][1,2]oxaborol-1(3H)-ol
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A1375670943311-35-198%

5-Fluoro-6-nitrobenzo[c][1,2]oxaborol-1(3H)-ol

$871.00/5g Detail

7-Fluoro-1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborole-6-carboxylic acid
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A16703831628151-46-195%

7-Fluoro-1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborole-6-carboxylic acid

$377.00/250mg Detail

3-Methyl-1,3-dihydro-2,1-benzoxaborol-1-ol
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A70260892203-40-295%

3-Methyl-1,3-dihydro-2,1-benzoxaborol-1-ol

$792.00/1g Detail

5-Fluoro-3-methylbenzo[c][1,2]oxaborol-1(3H)-ol
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A1710434905710-75-098%

5-Fluoro-3-methylbenzo[c][1,2]oxaborol-1(3H)-ol

$729.00/1g Detail

3-Phenylbenzo[c][1,2]oxaborol-1(3H)-ol
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A1093319174671-49-995%

3-Phenylbenzo[c][1,2]oxaborol-1(3H)-ol

$894.00/1g Detail

2-(1-Hydroxy-1,3-dihydro-2,1-benzoxaborol-3-yl)acetic acid
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A106450619203-45-395%

2-(1-Hydroxy-1,3-dihydro-2,1-benzoxaborol-3-yl)acetic acid

$706.00/1g Detail

3,3-Dimethylbenzo[c][1,2]oxaborol-1(3H)-ol
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A273232221352-10-995%

3,3-Dimethylbenzo[c][1,2]oxaborol-1(3H)-ol

$1617.00/25g Detail

6-Amino-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol
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A11819701266320-01-798%

6-Amino-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol

$743.00/1g Detail

1-Hydroxy-3,3-dimethyl-1,3-dihydrobenzo[c][1,2]oxaborole-6-carboxylic acid
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A10474601393477-51-495%

1-Hydroxy-3,3-dimethyl-1,3-dihydrobenzo[c][1,2]oxaborole-6-carboxylic acid

$2727.00/5g Detail

1-Hydroxy-6-(trifluoromethyl)benzo[c][1,2]oxaborol-3(1H)-one
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A15210692828438-87-397%

1-Hydroxy-6-(trifluoromethyl)benzo[c][1,2]oxaborol-3(1H)-one

$91.00/250mg Detail

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