Home Chemistry Organic Building Blocks Fluorinated Building Blocks 1-Fluoro-3-Methoxybenzene
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —F,—OCH3).
Fluorine Substitution: Fluorobenzene can undergo further substitution reactions to replace the fluorine atom with other functional groups. This can be achieved through nucleophilic aromatic substitution reactions. The electron-withdrawing nature of fluorine can affect the regioselectivity and reactivity of such substitutions.
Borohydride Demethylation: Methoxybenzene can undergo demethylation reactions using sodium borohydride (NaBH4) in the presence of a proton source, resulting in the formation of phenol.
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(3-Bromo-6-fluoro-2-methoxyphenyl)boronic acid
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