Chemistry Heterocyclic Building Blocks Pyridines 2,6-Dichloronicotinonitrile

2,6-Dichloronicotinonitrile

These compounds have the same murcko framework: 2,6-dichloronicotinonitrile

Substitution Reactions: The chlorine atoms on the pyridine ring can undergo substitution reactions with other nucleophiles. For example, they can be replaced by other halogens, such as bromine or iodine, or by alkyl or aryl groups.
Nucleophilic Addition Reactions: The cyano group (-CN) can undergo nucleophilic addition reactions, where a nucleophile adds to the carbon atom of the cyano group. This could lead to the formation of amines or other functional groups depending on the reaction conditions.
Reduction Reactions: The cyano group can be reduced to form primary amines using reducing agents such as lithium aluminum hydride (LiAlH4) or hydrogen gas in the presence of a catalyst.
Grignard Reactions: 2,6-dichloronicotinonitrile can undergo Grignard reactions where the cyano group is converted into a ketone after reaction with a Grignard reagent.
Metal-Catalyzed Cross-Coupling Reactions: The halogen atoms can undergo cross-coupling reactions with organometallic reagents (such as organolithium or organomagnesium compounds) in the presence of a transition metal catalyst to form biaryl compounds.
Ring-Opening Reactions: Under certain conditions, the pyridine ring may undergo ring-opening reactions, leading to the formation of open-chain compounds.
Oxidation Reactions: The compound can undergo oxidation reactions, for example, the oxidation of the cyano group to a carboxylic acid or other oxidized functional groups.

Further Reading:

Framework+−

(2-Chloropyridin-4-Yl)Boronic Acid (3-Bromopyridin-2-Yl)Methanol (3-Chloropyridin-2-Yl)Methanamine (3-Fluoropyridin-2-Yl)Methanamine (3-Methylpyridin-2-Yl)Methanamine (3-Methylpyridin-2-Yl)Methanol (3Ar,8As)-2-(Pyridin-2-Yl)-3A,8A-Dihydro-8H-Indeno[1,2-D]Oxazole (3As,8Ar)-2-(Pyridin-2-Yl)-3A,8A-Dihydro-8H-Indeno[1,2-D]Oxazole (4R,5S)-4,5-Diphenyl-2-(Pyridin-2-Yl)-4,5-Dihydrooxazole (5-(Trifluoromethyl)Pyridin-3-Yl)Boronic Acid (5-Bromopyridin-2-Yl)Methanamine (5-Bromopyridin-2-Yl)Methanol (5-Chloropyridin-2-Yl)Methanamine (6-Methylpyridin-2-Yl)Methanamine (6-Methylpyridin-2-Yl)Methanol (6-Phenoxypyridin-3-Yl)Boronic Acid (R)-3-(Pyrrolidin-2-Yl)Pyridine (R)-4-Benzyl-2-(Pyridin-2-Yl)-4,5-Dihydrooxazole (R)-4-Phenyl-2-(Pyridin-2-Yl)-4,5-Dihydrooxazole (S)-4-(Tert-Butyl)-2-(Pyridin-2-Yl)-4,5-Dihydrooxazole (S)-4-Benzyl-2-(Pyridin-2-Yl)-4,5-Dihydrooxazole (S)-4-Isopropyl-2-(Pyridin-2-Yl)-4,5-Dihydrooxazole (S)-4-Phenyl-2-(Pyridin-2-Yl)-4,5-Dihydrooxazole 1,1'-Diphenyl-[4,4'-Bipyridine]-1,1'-Diium 1,10-Phenanthrolin-4-Ol 1,2,3,4-Tetrahydropyrido[2,3-B]Pyrazine 1,2,3,6-Tetrahydropyridine 1,3-Dihydro-2H-Pyrrolo[2,3-B]Pyridin-2-One 1,3-Dihydro-2H-Pyrrolo[2,3-C]Pyridin-2-One 1,3-Dihydro-2H-Pyrrolo[3,2-B]Pyridin-2-One 1,4-Di(Pyridin-4-Yl)Benzene 1-(5-Bromopyridin-2-Yl)Piperazine 1-(Phenylsulfonyl)-1H-Pyrrolo[2,3-B]Pyridine 1-(Pyridin-2-Yl)Ethan-1-Amine 1-(Pyridin-2-Yl)Ethan-1-One 1-(Pyridin-2-Yl-L2-Azaneyl)Ethan-1-One 1-(Pyridin-3-Yl)Ethan-1-Amine 1-(Pyridin-3-Yl)Ethan-1-One 1-(Pyridin-3-Yl)Piperazine 1-(Pyridin-3-Ylmethyl)Piperazine 1-(Pyridin-4-Yl)Ethan-1-Amine 1-(Pyridin-4-Yl)Ethan-1-One 1-Benzyl-1,2,3,6-Tetrahydropyridine 1-Benzyl-1H-Pyrazolo[3,4-B]Pyridine 1-Methyl-4-(Pyridin-2-Yl)Piperazine 1-Methylpyridin-1-Ium Iodide 1-Phenyl-3-(4-(Pyridin-4-Yloxy)Phenyl)Urea 1H-Imidazo[4,5-B]Pyridine 1H-Imidazo[4,5-C]Pyridine 1H-Pyrazolo[3,4-B]Pyridin-5-Amine 1H-Pyrrolo[2,3-C]Pyridin-7-Ol 1H-Pyrrolo[2,3-C]Pyridine-2-Carboxylic Acid 1H-Pyrrolo[3,2-B]Pyridine-3-Carboxylic Acid 2,2':6',2''-Terpyridine 2,2-Dimethyl-1-(Pyridin-2-Yl-L2-Azaneyl)Propan-1-One 2,3'-Bipyridine 2,3,4,5-Tetrahydro-1H-Pyrido[4,3-B]Indole 2,3,4,9-Tetrahydro-1H-Pyrido[3,4-B]Indole 2,3,5-Trichloropyridine 2,3,6-Trichloropyridine 2,3-Dibromopyridine 2,3-Dichloropyridine 2,3-Difluoropyridine 2,3-Dihydro-1H-Pyrrolo[2,3-B]Pyridine 2,3-Dihydro-1H-Pyrrolo[2,3-C]Pyridine 2,3-Dihydro-1H-Pyrrolo[3,2-C]Pyridine 2,3-Dihydro-1H-Pyrrolo[3,4-C]Pyridine 2,3-Dihydro-[1,4]Dioxino[2,3-B]Pyridine 2,3-Dihydropyridin-2-One 2,3-Dimethoxypyridine 2,3-Dimethylpyridine 2,4,6-Trichloropyridine 2,4,6-Triphenylpyridine 2,4-Dibromopyridine 2,4-Dichloro-6-Methylpyridine 2,4-Dichloropyridine 2,4-Dimethylpyridine 2,5-Dibromopyridine 2,5-Dichloropyridine 2,5-Difluoropyridine 2,6-Bis(4,5-Dihydrooxazol-2-Yl)Pyridine 2,6-Di(1H-Pyrazol-1-Yl)Pyridine 2,6-Dibromo-3-Fluoropyridine 2,6-Dibromopyridin-4-Amine 2,6-Dibromopyridine 2,6-Dichloro-3-Fluoropyridine 2,6-Dichloro-3-Methylpyridine 2,6-Dichloro-3-Nitropyridine 2,6-Dichloro-4-Iodopyridine 2,6-Dichloro-4-Methylpyridine 2,6-Dichloronicotinonitrile 2,6-Dichloropyridin-3-Amine 2,6-Dichloropyridine 2,6-Difluoropyridine 2,6-Dimethoxypyridine 2,6-Dimethylpyridin-4-Ol 2,6-Dimethylpyridine 2-(1H-Pyrazol-1-Yl)Pyridine 2-(1H-Pyrazol-3-Yl)Pyridine 2-(2,2,2-Trifluoroethoxy)Pyridine 2-(2-Chlorophenyl)Pyridine 2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine 2-(4-Fluorophenyl)Pyridine 2-(6-Benzhydrylpyridin-2-Yl)-4,5-Dihydrooxazole 2-(6-Cyclopropylpyridin-2-Yl)-4,5-Dihydrooxazole 2-(Benzyloxy)Pyridine 2-(Bromomethyl)Pyridine 2-(Chloromethyl)-3-Methylpyridine 2-(Chloromethyl)Pyridine 2-(Chloromethyl)Pyridine 1-Oxide 2-(Difluoromethyl)Pyridine 2-(Methylsulfonyl)Pyridine 2-(Methylthio)Pyridine 2-(P-Tolyl)Pyridine 2-(Phenoxymethyl)Pyridine 2-(Piperidin-1-Yl)Pyridine 2-(Piperidin-4-Yl)Pyridine 2-(Pyridin-2-Yl)-1H-Benzo[D]Imidazole 2-(Pyridin-2-Yl)Acetonitrile 2-(Pyridin-2-Yl)Pyrimidine 2-(Pyridin-2-Ylmethyl)-4,5-Dihydrooxazole 2-(Pyridin-3-Yl)Acetic Acid 2-(Pyridin-3-Yl)Acetonitrile 2-(Pyrrolidin-2-Yl)Pyridine 2-(Thiophen-2-Yl)Pyridine 2-(Tributylstannyl)Pyridine 2-(Trifluoromethoxy)Pyridine 2-(Trifluoromethyl)Pyridine 2-Aminonicotinonitrile 2-Benzylpyridine 2-Bromo-3-(Trifluoromethyl)Pyridine 2-Bromo-3-Chloropyridine 2-Bromo-3-Fluoropyridine 2-Bromo-3-Iodopyridine 2-Bromo-3-Methoxypyridine 2-Bromo-3-Methylpyridine 2-Bromo-3-Nitropyridine 2-Bromo-4-Chloropyridine 2-Bromo-4-Methylpyridine 2-Bromo-5-(Trifluoromethyl)Pyridine 2-Bromo-5-Chloropyridine 2-Bromo-5-Fluoropyridine 2-Bromo-5-Methoxypyridine 2-Bromo-5-Methylpyridine 2-Bromo-5-Nitropyridine 2-Bromo-6-(Trifluoromethyl)Pyridine 2-Bromo-6-Chloropyridine 2-Bromo-6-Fluoropyridine 2-Bromo-6-Iodopyridine 2-Bromo-6-Methoxypyridine 2-Bromo-6-Methylpyridine 2-Bromo-6-Phenylpyridine 2-Bromonicotinic Acid 2-Bromopyridin-3-Amine 2-Bromopyridin-3-Ol 2-Bromopyridine 2-Bromopyridine 1-Oxide 2-Chloro-3,6-Dimethylpyridine 2-Chloro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine 2-Chloro-3-(Trifluoromethyl)Pyridine 2-Chloro-3-Fluoropyridin-4-Amine 2-Chloro-3-Fluoropyridine 2-Chloro-3-Iodopyridin-4-Amine 2-Chloro-3-Iodopyridine 2-Chloro-3-Methoxypyridine 2-Chloro-3-Methylpyridine 2-Chloro-3-Nitropyridine 2-Chloro-4,6-Dimethylpyridine 2-Chloro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine 2-Chloro-4-(Trifluoromethyl)Pyridine 2-Chloro-4-Ethoxypyridine 2-Chloro-4-Fluoropyridine 2-Chloro-4-Iodopyridine 2-Chloro-4-Methoxypyridine 2-Chloro-4-Methylpyridine 2-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine 2-Chloro-5-(Trifluoromethyl)Pyridine 2-Chloro-5-Fluoropyridin-4-Amine 2-Chloro-5-Fluoropyridine 2-Chloro-5-Iodopyridine 2-Chloro-5-Methylpyridine 2-Chloro-5-Nitropyridine 2-Chloro-6-(Trifluoromethyl)Pyridine 2-Chloro-6-Fluoropyridine 2-Chloro-6-Iodopyridine 2-Chloro-6-Methoxypyridine 2-Chloro-6-Methyl-3-Nitropyridine 2-Chloro-6-Methylnicotinonitrile 2-Chloro-6-Methylpyridine 2-Chloroisonicotinaldehyde 2-Chloroisonicotinic Acid 2-Chloroisonicotinonitrile 2-Chloronicotinic Acid 2-Chloronicotinonitrile 2-Chloropyridin-3-Amine 2-Chloropyridin-3-Ol 2-Chloropyridin-4-Amine 2-Chloropyridine 1-Oxide 2-Cyclopropyl-4-Phenylquinoline 2-Cyclopropylpyridine 2-Ethoxypyridine 2-Ethylpyridine 2-Ethynylpyridine 2-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine 2-Fluoro-3-Iodopyridine 2-Fluoro-3-Methylpyridine 2-Fluoro-4-Methylpyridine 2-Fluoro-5-Methoxypyridine 2-Fluoro-5-Methylpyridine 2-Fluoro-6-Methoxypyridine 2-Fluoro-6-Methylpyridine 2-Fluoropyridine 2-Hydrazineylpyridine 2-Iodo-6-Methylpyridine 2-Iodopyridine 2-Isopropoxypyridine 2-Isopropylpyridine 2-Methoxy-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine 2-Methoxy-3-(Trifluoromethyl)Pyridine 2-Methoxy-4-Methylpyridine 2-Methoxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine 2-Methoxy-5-(Trifluoromethyl)Pyridine 2-Methoxy-5-Methylpyridine 2-Methoxy-5-Nitropyridine 2-Methoxy-6-Methylpyridine 2-Methoxyisonicotinic Acid 2-Methoxypyridin-3-Amine 2-Methoxypyridine 2-Methyl-1,10-Phenanthroline 2-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine 2-Methyl-3-Nitropyridine 2-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine 2-Methylimidazo[1,2-A]Pyridine 2-Methylpyridin-3-Ol 2-Methylpyridin-4-Amine 2-Methylpyridine 1-Oxide 2-Nitropyridine 2-Phenoxy-5-(Trifluoromethyl)Pyridine 2-Phenylimidazo[1,2-A]Pyridine 2-Propoxypyridine 2H-Pyrido[3,2-B][1,4]Oxazin-3(4H)-One 3,3'-Bipyridine 3,4-Dihydro-2H-Pyrido[3,2-B][1,4]Oxazine 3,5-Dibromopyridine 3,5-Dichloropyridine 3,5-Difluoropyridine 3,5-Dimethoxypyridine 3,5-Dimethylpyridine 3,5-Diphenylpyridine 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Trifluoromethyl)Pyridine 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine 3-(Benzyloxy)Pyridine 3-(Bromomethyl)Pyridine 3-(Chloromethyl)Pyridine 3-(Cyclopropylmethyl)Pyridine 3-(Difluoromethyl)Pyridine 3-(Methylsulfonyl)Pyridine 3-(Piperidin-1-Yl)Pyridine 3-(Piperidin-4-Yl)Pyridine 3-(Pyrrolidin-2-Yl)Pyridine 3-(Tert-Butyl)Pyridine 3-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine 3-(Trifluoromethyl)Pyridin-2-Ol 3-(Trifluoromethyl)Pyridine 3-Bromo-1H-Pyrrolo[3,2-B]Pyridine 3-Bromo-2-Chloropyridin-4-Amine 3-Bromo-2-Chloropyridine 3-Bromo-2-Fluoropyridine 3-Bromo-2-Methoxypyridine 3-Bromo-2-Methylpyridine 3-Bromo-4-Methylpyridine 3-Bromo-5-Chloropyridine 3-Bromo-5-Fluoropyridine 3-Bromo-5-Methylpyridine 3-Bromo-5-Nitropyridine 3-Bromopicolinic Acid 3-Bromopicolinonitrile 3-Bromopyrazolo[1,5-A]Pyridine 3-Bromopyridin-2-Amine 3-Bromopyridin-2-Ol 3-Bromopyridine 1-Oxide 3-Chloro-2-Fluoropyridine 3-Chloro-2-Methoxypyridine 3-Chloro-2-Methylpyridine 3-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine 3-Chloro-5-Fluoropyridine 3-Chloro-5-Methylpyridine 3-Chloro-5-Nitropyridine 3-Chloroimidazo[1,2-A]Pyridine 3-Chloropicolinic Acid 3-Chloropicolinonitrile 3-Chloropyridin-2-Amine 3-Chloropyridin-2-Ol 3-Cyclopropylpyridine 3-Ethoxypyridine 3-Ethylpyridine 3-Ethynylpyridine 3-Fluoro-2-Methoxypyridine 3-Fluoro-2-Methylpyridine 3-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine 3-Fluoropicolinic Acid 3-Fluoropicolinonitrile 3-Fluoropyridin-2-Amine 3-Fluoropyridin-4-Amine 3-Hydrazineylpyridine 3-Iodo-1H-Pyrazolo[3,4-B]Pyridine 3-Iodo-1H-Pyrrolo[3,2-B]Pyridine 3-Iodo-1H-Pyrrolo[3,2-C]Pyridine 3-Iodopyridin-2-Amine 3-Iodopyridin-2-Ol 3-Iodopyridin-4-Amine 3-Iodopyridin-4-Ol 3-Iodopyridine 3-Methoxypyridin-2-Amine 3-Methoxypyridine 3-Methyl-1H-Pyrrolo[2,3-B]Pyridine 3-Methyl-2-Phenylpyridine 3-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine 3-Methyl-5-Nitropyridine 3-Methylimidazo[1,2-A]Pyridine 3-Methylpicolinic Acid 3-Methylpyridin-2-Amine 3-Methylpyridine 3-Methylpyridine 1-Oxide 3-Nitropyridin-2-Ol 3-Nitropyridin-4-Amine 3-Nitropyridine 3-Phenoxypyridine 4'-Phenyl-2,2':6',2''-Terpyridine 4,4'-Bipyridine 4,5,6,7-Tetrahydro-1H-Pyrazolo[3,4-C]Pyridine 4,5,6,7-Tetrahydro-1H-Pyrazolo[4,3-C]Pyridine 4,5,6,7-Tetrahydro-3H-Imidazo[4,5-C]Pyridine 4,5,6,7-Tetrahydrothiazolo[5,4-C]Pyridine 4,5,6,7-Tetrahydrothieno[2,3-C]Pyridine 4,5,6,7-Tetrahydrothieno[3,2-C]Pyridine 4,6-Dichloropyridin-2-Amine 4,6-Dichloropyridin-3-Amine 4,7-Diphenyl-1,10-Phenanthroline 4-(2,4-Diphenyl-1H-Imidazol-5-Yl)Pyridine 4-(Benzyloxy)Pyridine 4-(Bromomethyl)Pyridine 4-(Pyridin-2-Yl)Morpholine 4-(Pyridin-3-Yl)Pyrimidine 4-(Pyridin-4-Yl)Morpholine 4-(Tert-Butyl)-2-(Pyridin-2-Yl)-4,5-Dihydrooxazole 4-(Tert-Butyl)Pyridine 4-(Trifluoromethyl)Nicotinic Acid 4-(Trifluoromethyl)Pyridine 4-Bromo-2-Chloropyridine 4-Bromo-2-Fluoropyridine 4-Bromo-2-Methoxypyridine 4-Bromo-3-Methylpyridine 4-Bromopyrazolo[1,5-A]Pyridine 4-Bromopyridine 4-Chloro-1H-Pyrazolo[4,3-C]Pyridine 4-Chloro-1H-Pyrrolo[2,3-B]Pyridine 4-Chloro-1H-Pyrrolo[3,2-C]Pyridine 4-Chloro-2,6-Dimethylpyridine 4-Chloro-2-Methoxypyridine 4-Chloro-3-Methylpyridine 4-Chloronicotinic Acid 4-Chloropyridin-2-Amine 4-Chloropyridine 4-Cyclopropylpyridine 4-Ethoxypyridine 4-Ethynylpyridine 4-Iodopyridine 4-Isopropyl-2-(Pyridin-2-Yl)-4,5-Dihydrooxazole 4-Methoxypyridine 4-Methyl-2,2'-Bipyridine 4-Methyl-2-Phenylpyridine 4-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine 4-Methyl-3-Nitropyridine 4-Methylnicotinic Acid 4-Methylpyridine 4-Nitropyridine 4-Phenoxypyridine 4-Phenyl-1,2,3,6-Tetrahydropyridine 4-Phenyl-1,4-Dihydropyridine 5,6,7,8-Tetrahydroimidazo[1,2-A]Pyridine 5,6,7,8-Tetrahydropyrido[3,4-D]Pyrimidine 5,6,7,8-Tetrahydropyrido[4,3-D]Pyrimidine 5,6-Dichloropyridin-2-Amine 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Nicotinonitrile 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine 5-(Trifluoromethyl)Pyridin-2-Amine 5-(Trifluoromethyl)Pyridin-2-Ol 5-Benzyl-4,5,6,7-Tetrahydrothieno[3,2-C]Pyridine 5-Bromo-2-Chloro-4-Methylpyridine 5-Bromo-2-Chloropyridine 5-Bromo-2-Fluoropyridine 5-Bromo-2-Iodopyridine 5-Bromo-2-Methoxypyridine 5-Bromo-2-Methylpyridine 5-Bromo-2-Phenylpyridine 5-Bromo-4-Methylpyridin-2-Amine 5-Bromo-6-Chloropyridin-2-Amine 5-Bromonicotinaldehyde 5-Bromonicotinic Acid 5-Bromonicotinonitrile 5-Bromopicolinic Acid 5-Bromopicolinonitrile 5-Bromopyridin-2-Amine 5-Bromopyridin-2-Ol 5-Bromopyridin-3-Amine 5-Bromopyridin-3-Ol 5-Chloro-1H-Pyrazolo[3,4-B]Pyridine 5-Chloro-1H-Pyrazolo[4,3-B]Pyridine 5-Chloro-1H-Pyrrolo[2,3-C]Pyridine 5-Chloro-1H-Pyrrolo[3,2-B]Pyridine 5-Chloro-2-Fluoropyridine 5-Chloro-2-Methoxypyridine 5-Chloro-2-Methylpyridine 5-Chloroimidazo[1,2-A]Pyridine 5-Chloropicolinic Acid 5-Chloropicolinonitrile 5-Chloropyridin-2-Amine 5-Chloropyridin-2-Ol 5-Chloropyridin-3-Amine 5-Fluoro-2-Methoxypyridine 5-Fluoro-2-Methylpyridine 5-Fluoropicolinonitrile 5-Fluoropyridin-2-Amine 5-Iodopyridin-2-Amine 5-Iodopyridin-2-Ol 5-Methoxy-1H-Pyrrolo[2,3-C]Pyridine 5-Methoxypyridin-3-Amine 5-Methylimidazo[1,2-A]Pyridine 5-Methylpyridin-2-Amine 5-Methylpyridin-3-Amine 5-Nitronicotinic Acid 5-Nitropyridin-2-Amine 5-Phenylpicolinic Acid 6,7-Dihydro-5H-Cyclopenta[B]Pyridine 6,7-Dihydro-5H-Cyclopenta[C]Pyridine 6,7-Dihydro-5H-Pyrrolo[3,4-B]Pyridine 6-(Trifluoromethyl)Pyridin-2-Amine 6-(Trifluoromethyl)Pyridin-3-Amine 6-Bromo-1H-Pyrazolo[4,3-B]Pyridine 6-Bromo-1H-Pyrrolo[3,2-B]Pyridine 6-Bromo-1H-Pyrrolo[3,2-C]Pyridine 6-Bromoimidazo[1,2-A]Pyridine 6-Bromonicotinaldehyde 6-Bromonicotinic Acid 6-Bromonicotinonitrile 6-Bromopicolinic Acid 6-Bromopyrazolo[1,5-A]Pyridine 6-Bromopyridin-2-Amine 6-Bromopyridin-3-Amine 6-Bromopyridin-3-Ol 6-Chloro-1H-Pyrazolo[4,3-C]Pyridine 6-Chloro-1H-Pyrrolo[3,2-C]Pyridine 6-Chloro-3-Nitropyridin-2-Amine 6-Chloro-5-(Trifluoromethyl)Pyridin-2-Amine 6-Chloro-5-Iodopyridin-2-Amine 6-Chloroimidazo[1,2-A]Pyridine 6-Chloronicotinaldehyde 6-Chloronicotinic Acid 6-Chloropicolinic Acid 6-Chloropicolinonitrile 6-Chloropyridin-2-Amine 6-Chloropyridin-2-Ol 6-Chloropyridin-3-Amine 6-Chloropyridine-3-Sulfonyl Chloride 6-Fluoro-1H-Pyrrolo[2,3-B]Pyridine 6-Fluoropyridin-2-Amine 6-Fluoropyridin-3-Amine 6-Methoxy-1H-Pyrrolo[2,3-B]Pyridine 6-Methoxynicotinaldehyde 6-Methoxypicolinic Acid 6-Methoxypyridin-2-Amine 6-Methoxypyridin-3-Amine 6-Methylnicotinic Acid 6-Methylnicotinonitrile 6-Methylpicolinic Acid 6-Methylpicolinonitrile 6-Methylpyridin-2-Amine 6-Methylpyridin-2-Ol 6-Methylpyridin-3-Amine 6-Methylpyridin-3-Ol 6-Phenoxypyridin-3-Amine 6-Phenylnicotinic Acid 6-Phenylpicolinic Acid 7-Bromo-1H-Pyrrolo[2,3-C]Pyridine 7-Chloro-1H-Pyrrolo[2,3-C]Pyridine 7-Methoxy-1H-Pyrrolo[2,3-C]Pyridine 7-Methylimidazo[1,2-A]Pyridine 9H-Pyrido[3,4-B]Indole Bis(Pyridin-2-Ylmethyl)Amine Dimethyl Pyridine-2,6-Dicarboxylate Dimethyl(Pyridin-2-Yl)Phosphine Oxide Dimethyl(Pyridin-3-Yl)Phosphine Oxide Ethyl 2-(Pyridin-2-Yl)Acetate Ethyl 2-Methylnicotinate Ethyl 4,6-Dichloronicotinate Ethyl 6-Chloropicolinate Ethyl Isonicotinate Ethyl Nicotinate Ethyl Picolinate Ethyl Pyrazolo[1,5-A]Pyridine-3-Carboxylate Furo[3,2-B]Pyridine Furo[3,2-C]Pyridine Imidazo[1,2-A]Pyridin-2-Ylmethanol Imidazo[1,2-A]Pyridine-5-Carboxylic Acid Imidazo[1,2-A]Pyridine-6-Carbonitrile Isonicotinaldehyde Isonicotinamide Isonicotinic Acid Isonicotinohydrazide Isonicotinonitrile Methyl 1H-Pyrazolo[3,4-B]Pyridine-5-Carboxylate Methyl 1H-Pyrrolo[2,3-B]Pyridine-2-Carboxylate Methyl 2-(Pyridin-2-Yl)Acetate Methyl 2-Chloroisonicotinate Methyl 2-Chloronicotinate Methyl 3-Bromopicolinate Methyl 3-Chloropicolinate Methyl 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Nicotinate Methyl 5-Hydroxypicolinate Methyl 6-Bromonicotinate Methyl 6-Chloropicolinate Methyl 6-Fluoronicotinate Methyl 6-Methoxynicotinate Methyl Isonicotinate Methyl Nicotinate Methyl Pyrazolo[1,5-A]Pyridine-3-Carboxylate N,N-Dimethylpyridin-2-Amine N,N-Dimethylpyridin-4-Amine N-(Pyridin-2-Yl)Benzamide N-Benzylpyridin-2-Amine N-Methylpicolinamide N-Methylpyridin-2-Amine N-Methylpyridin-3-Amine N-Phenyl-4-(Pyridin-3-Yl)Pyrimidin-2-Amine N-Phenylpicolinamide N-Phenylpyridin-2-Amine Nicotinaldehyde Nicotinamide Nicotinic Acid Nicotinonitrile Oxazolo[4,5-B]Pyridine Oxazolo[5,4-B]Pyridine Phenyl(Pyridin-2-Yl)Methanone Phenyl(Pyridin-3-Yl)Methanone Picolinaldehyde Picolinamide Picolinic Acid Picolinimidamide Picolinohydrazide Pyrazolo[1,5-A]Pyridine-2-Carboxylic Acid Pyrazolo[1,5-A]Pyridine-3-Carboxylic Acid Pyridin-2-Amine Pyridin-2-Ol Pyridin-2-Ylboronic Acid Pyridin-2-Ylmethanamine Pyridin-2-Ylmethanol Pyridin-3-Amine Pyridin-3-Ol Pyridin-3-Ylboronic Acid Pyridin-3-Ylmethanamine Pyridin-3-Ylmethanol Pyridin-4-Amine Pyridin-4-Ol Pyridin-4-Ylboronic Acid Pyridin-4-Ylmethanamine Pyridin-4-Ylmethanol Pyridine 1-Oxide Pyridine-2,3-Diamine Pyridine-2,6-Diamine Pyridine-2,6-Dicarboxylic Acid Pyridine-2,6-Diol Pyridine-2-Sulfonamide Pyridine-2-Sulfonyl Chloride Pyridine-2-Thiol Pyridine-3-Sulfonic Acid Pyridine-3-Sulfonyl Chloride Pyrido[2,3-B]Pyrazine Pyrido[2,3-D]Pyrimidine Pyrido[3,2-D]Pyrimidine Pyrido[3,4-B]Pyrazine Pyrido[3,4-D]Pyrimidine Tert-Butyl (2-Chloropyridin-4-Yl)Carbamate Tert-Butyl 1H-Pyrazolo[3,4-B]Pyridine-1-Carboxylate Tert-Butyl 4-(Pyridin-2-Yl)Piperazine-1-Carboxylate Tert-Butyl Pyridin-2-Ylcarbamate Tert-Butyl Pyridin-3-Ylcarbamate Tert-Butyl Pyridin-4-Ylcarbamate Thiazolo[4,5-B]Pyridine Thiazolo[5,4-B]Pyridine Thiazolo[5,4-C]Pyridine Thieno[2,3-B]Pyridine Thieno[2,3-C]Pyridine Thieno[3,2-B]Pyridine Thieno[3,2-C]Pyridine

By Key Group+−

2-Pyridone Derivatives Acetylpyridin Aminopicolinate Aminopicolinic Aminopyridine Benzyloxypyridine Bipyridine Bromo-Picolin-Amide Bromopicolinaldehyde Bromopicolinate Bromopicolinic Bromopicolinic Acid Bromopicolinonitrile Bromopyridine Bromopyrido Bromotriazolopyridine Butylpyridine Carbazo-Pyridine Chloro-Pyrrolopyridine-Carboxylate Chloro-Triazolopyridine Chloroisonicotinic Chloroisonicotinic Acid Chloronicotinaldehyde Chloronicotinamide Chloronicotinate Chloronicotinic Chloropyridine Chlorpyridine-Boronate Cyanopicolinate Cyanopicolinic Cyanopyridine Cyclopropoxypyridine Cyclopropylpyridine Dibromopicolinate Dibromopicolinic Dibromopicolinic Acid Dibromopyridine Dichloropicolinate Dichloropicolinic Dichloropicolinonitrile Dichloropyridine Difluoromethyl-Pyridine Difluoronicotinic Difluoropicolinic Difluoropicolinic Acid Difluoropyridine Dihydropyridine Dihydropyrido Dihydroxy-Pyridine Dihydroxypyridine Diiodopyridine Dimethoxypicolinic Dimethoxypicolinic Acid Dimethoxypyridine Dimethylpyridine Diphenylpyridine Dipicolinamide Dipyridine Ethoxypicolinic Ethoxypicolinic Acid Ethoxypyridine Ethylpyridine Ethynylpicolinate Ethynylpyridine Fluoro-Pyridine--Boronate Fluoro-Pyridine-Borate Fluoro-Pyridine-Borolane Fluoro-Triazolopyridine Fluoro-Trifluoromethyl-Pyridine Fluoropicolinaldehyde Fluoropicolinamide Fluoropicolinate Fluoropyridine Fluoropyrido Formylpicolinate Formylpyridine Furopyridine Hexahydropyrido Hydrazinylpyridine Hydroxymethylpyridine Hydroxypicolinate Hydroxypicolinic Hydroxypicolinonitrile Hydroxypyridine Imidazol-Pyridine Imidazopyridin-Amine Imidazopyridine Iodo-Pyrazolopyridine Iodopicolinate Iodopicolinic Iodopicolinic Acid Iodopyridine Isonicotinic Isopropoxypyridine Isopropylpyridine Methoxy-Pyridine-Boronate Methoxy-Pyrrolopyridine Methoxy-Trifluoromethyl-Pyridine Methoxyisonicotinaldehyde Methoxynicotinaldehyde Methoxypicolinaldehyde Methoxypicolinamide Methoxypicolinate Methoxypicolinic Methoxypicolinic Acid Methoxypicolinimidamide Methoxypicolinonitrile Methoxypyridine Methyl-Imidazopyridine Methyl-Pyrazolopyridine Methyl-Pyrrolopyridine Methyl-Triazolopyridine Methylisonicotinamide Methylisonicotinate Methylnicotinaldehyde Methylnicotinamide Methylpicolinaldehyde Methylpicolinamide Methylpicolinate Methylpicolinic Methylpicolinonitrile Methylpyridine Methylpyrido Nitropyridine Oxadiazo-Pyridine Oxazolopyridine Oxopyridin Phenoxypyridin Phenylpicolinate Phenylpyridine Picolinate Picoline-Boronate Picolinic Piperazine-Pyridine Pyranopyridine Pyrazol-Pyridine Pyrazolopyridin-Ol Pyrazolopyridine Pyridin-Benzene Pyridin-Benzoimidazole Pyridin-Ethanamine Pyridin-Methanamine Pyridin-Piperidine Pyridin-Pyrimidin Pyridin-Quinoline Pyridinamine Pyridine-Boronate Pyridine-Hydrochloride Pyridine-Propylamine Pyridine-Pyrazole Pyridine-Pyrrole Pyridine-Pyrrolidine Pyridine-Thiazol-Amide Pyridine-Thiazole Pyridineboronic Acid Pyridinecarbonitrile Pyridinecarboxylate Pyridinecarboxylic Pyridinemethanol Pyridinoindole Pyridinone Pyridonaphthyridine Pyridone Boronate Pyridooxazin-One Pyridopyrazine Pyridopyrimidin Pyridoxazine Pyridyl-Benzene-Boronic Acid Pyridyl-Benzene-Boronic Acid/Ester Pyridyl-Benzene-Boronic-Acid Pyridyl-Ethanol Pyridyl-Morpholine Pyridyl-Phenyl-Borate Pyridyl-Phenyl-Boronate Pyridyl-Triazine Pyridylmethyl Pyrrolidin-Pyridine Pyrrolopyridine Pyrrolopyridine-Carboxylate Pyrrolopyrimidin-Amine Terpyridine Tetrachloropyridine Tetrafluoropyridine Tetrahydropyrazolopyridine Tetrahydropyridine Tetrahydropyrido Thiazolopyridine Thienopyridine Triazol-Pyridine Triazolopyridin-Amine Triazolopyridine Triazolopyridine-Carboxylate Triazolopyridine-Carboxylic Tribromopyridine Trichloropyridine Trichloropyrido Trifluoromethyl-Pyridin-Amine Trifluoromethyl-Pyridine-Ethylamine Trifluoromethyl-Pyridyl-Methanamine Trifluoromethylpyridine Trifluoropyridine Trimethylpyridine

By Parent Nucleus+−

Aliphatic Heterocycles Aromatic Heterocycles Azetidines Benzimidazoles Dioxolanes Guanidines Imidazoles Indazoles Indoles Indolines Morpholines Other Aliphatic Heterocycles Other Aromatic Heterocycles Oxazolines Oxetanes Piperazines Piperidines Purines Pyrazoles Pyrimidines Pyrroles Pyrrolidines Quinolines Spiroes Tetrahydropyrans Tetrahydroquinolines Thiadiazoles Thiazoles Thiazolidines Thiophenes Thiophenols Triazines Triazoles

By Functional Group+−

Acyl Chlorides Alcohols Aldehydes Aliphatic Chain Hydrocarbons Aliphatic Cyclic Hydrocarbons Alkenyls Alkyls Alkynyls Amides Amidines Amines Aryls Benzyl Bromides Benzyl Chlorides Bromides Carboxylic Acid Salts Carboxylic Acids Chiral Building Blocks Chlorides Difluoromethyls Esters Ethers Fluorinated Building Blocks Hydrazides Hydrazines Hydrazones Hydroxylamines Iodides Ketones Nitriles Nitroes Oximes Phenols Phosphoruses Sulfamides Sulfides Sulfonates Sulfones Sulfonic Acids Sulfonyl Chlorides Sulfoxides Thioesters Thioureas Trifluoromethyls Ureas

Heterocyclic related+−

Py

By Chemical Elements+−

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    Nx
    Ox
    Fx
    Six
    Px
    Sx
    Clx
    Brx
    Ix

    Formula Weight+−

    cLogP+−

    H-Acceptors+−

    H-Donors+−

    Polar Surface Area+−

    Druglikeness+−

    NNCH/NNH+−

    sp3-Atoms+−

    Non-Aromatic Rings+−

    Aromatic Rings+−

    Rotatable Bonds+−

    By Configuration+−

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    2,4,6-Trichloronicotinonitrile

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    A95740240381-91-795%

    2,4,6-Trichloronicotinonitrile

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    Methyl 2-(2,6-dichloro-3-cyanopyridin-4-yl)acetate

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    A42233839621-02-898%

    Methyl 2-(2,6-dichloro-3-cyanopyridin-4-yl)acetate

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    2,6-Dichloro-5-(trifluoromethyl)nicotinonitrile

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    A2018391319804-30-295%

    2,6-Dichloro-5-(trifluoromethyl)nicotinonitrile

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    2,6-Dichloro-3-cyanopyridine

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    A14324740381-90-697%

    2,6-Dichloro-3-cyanopyridine

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    2,6-Dichloro-4-methylnicotinonitrile

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    A583825875-35-498%

    2,6-Dichloro-4-methylnicotinonitrile

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    2,6-Dichloro-4-isopropylnicotinonitrile

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    A425530503843-54-797%

    2,6-Dichloro-4-isopropylnicotinonitrile

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    2,6-Dichloro-4-(difluoromethyl)nicotinonitrile

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    A632047960293-93-095%

    2,6-Dichloro-4-(difluoromethyl)nicotinonitrile

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    2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile

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    A25618713600-42-598%

    2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile

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