Chemistry Organic Building Blocks Chlorides 1-chloro-3-fluoro-2-nitrobenzene
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Cl,—NO2,—F).
Grignard Reaction: Chlorobenzene can react with magnesium metal to form phenylmagnesium chloride, which can then react with various electrophiles to introduce new functional groups onto the aromatic ring.
Sulfonation: Nitrobenzene can be sulfonated to introduce a sulfonic acid group (-SO3H) onto the benzene ring. Sulfonation is carried out using concentrated sulfuric acid, which leads to the substitution of one of the hydrogen atoms on the ring.
Fluorine Substitution: Fluorobenzene can undergo further substitution reactions to replace the fluorine atom with other functional groups. This can be achieved through nucleophilic aromatic substitution reactions. The electron-withdrawing nature of fluorine can affect the regioselectivity and reactivity of such substitutions.
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[1,2,4]Triazolo[4,3-a]pyridin-7-amine hydrochloride
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2-(3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate
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Methyl [1,2,4]triazolo[1,5-a]pyridine-6-carboxylate
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Ethyl [1,2,4]triazolo[1,5-a]pyridine-2-carboxylate
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[1,2,4]Triazolo[1,5-a]pyridine-6-boronic Acid Pinacol Ester
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[1,2,4]Triazolo[1,5-a]pyridin-6-ylboronic acid
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[1,2,4]Triazolo[1,5-a]pyridin-7-ylmethanol
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3-Methyl[1,2,4]triazolo[4,3-a]pyridin-7-amine
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Methyl 2-methyl-[1,2,4]triazolo[1,5-a]pyridine-6-carboxylate
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7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,2,4]triazolo[1,5-a]pyridine
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Methyl 3-(tert-butyl)-[1,2,4]triazolo[4,3-a]pyridine-6-carboxylate
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[1,2,4]Triazolo[4,3-a]pyridine-6-carboxylic acid
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[1,2,4]Triazolo[1,5-a]pyridine-6-carbonitrile
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3-Phenyl-[1,2,4]triazolo[4,3-a]pyridine-6-carboxylic acid
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2-Methyl-[1,2,4]triazolo[1,5-a]pyridin-8-amine
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2-Methyl-[1,2,4]triazolo[1,5-a]pyridine-6-carboxylic acid
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[1,2,4]triazolo[1,5-a]pyridine-6-carboxylic acid
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2-(Piperidin-4-yl)-6-(pyrrolidin-1-yl)-[1,2,4]triazolo[1,5-a]pyridine
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7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,2,4]triazolo[4,3-a]pyridine
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3-Methyl-3H-[1,2,3]triazolo[4,5-b]pyridine-6-carboxylic acid
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Lithium [1,2,4]triazolo[4,3-a]pyridine-3-carboxylate